Marmesinin - Compound Card

Marmesinin

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Marmesinin

Structure
Zoomed Structure
  • Family: Plantae - Apiaceae
  • Kingdom: Plantae
  • Class: Coumarin
Canonical Smiles OC[C@H]1O[C@@H](OC([C@H]2Oc3c(C2)cc2c(c3)oc(=O)cc2)(C)C)[C@@H]([C@H]([C@@H]1O)O)O
InChI InChI=1S/C20H24O9/c1-20(2,29-19-18(25)17(24)16(23)13(8-21)28-19)14-6-10-5-9-3-4-15(22)27-11(9)7-12(10)26-14/h3-5,7,13-14,16-19,21,23-25H,6,8H2,1-2H3/t13-,14+,16-,17+,18-,19+/m1/s1
InChIKey HXCGUCZXPFBNRD-NEDVQNLSSA-N
Formula C20H24O9
HBA 9
HBD 4
MW 408.4
Rotatable Bonds 4
TPSA 138.82
LogP -0.31
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 29
Formal Charge 0
Fraction CSP3 0.55
Exact Mass 408.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Ammi majus Apiaceae Plantae 48026

Showing of synonyms

  • Abu-Mustafa EA, Fayez MBE (1961). Natural coumarins I. marmesin and marmesinin, further products from the fruits of Ammi majus L.. The Journal of Organic Chemistry,1961,26(1),161-166. [View]
Pubchem: 216283
Chebi: 132401
Nmrshiftdb2: 60062056
Metabolights: MTBLC132401

No compound-protein relationship available.

Structure

SMILES: O1CCCCC1OCC(C2)Oc(c23)cc4c(c3)ccc(=O)o4

Level: 1

Mol. Weight: 408.4 g/mol

Structure

SMILES: C1COc(c12)cc3c(c2)ccc(=O)o3

Level: 0

Mol. Weight: 408.4 g/mol

Structure

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 408.4 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.44
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.690
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.01

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.910
Plasma Protein Binding
76.18
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.850
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
-1.350
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.820
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.490
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-22.180
Rat (Acute)
2.990
Rat (Chronic Oral)
2.860
Fathead Minnow
4.090
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Toxic

General Properties

Boiling Point
479.560
Hydration Free Energy
-8.890
Log(D) at pH=7.4
1.100
Log(P)
-0.07
Log S
-2.52
Log(Vapor Pressure)
-12.37
Melting Point
193.06
pKa Acid
5.68
pKa Basic
4.74
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9569
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9569
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8927
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8927
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8906
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8906
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.8869
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.8869
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.8867
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.8867
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8574
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8574
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8573
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8573
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8451
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8451
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8434
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8434
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8400
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8400
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8261
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8261
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8098
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8098
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8086
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8086
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7998
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7998
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7952
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7952
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7940
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7940
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7900
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7900
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7851
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7851
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7830
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7830
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7766
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7766
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7751
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7751
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7738
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7738
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7712
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7712
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7683
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7683
beta-glucosidase Q92AS9 Q92AS9_LISIN Listeria innocua serovar 6a 3 0.7657
beta-glucosidase Q92AS9 Q92AS9_LISIN Listeria innocua serovar 6a 3 0.7657
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7650
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7650
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7619
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7619
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7616
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7616
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7542
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7542
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7524
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7524
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7495
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7495
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7469
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7469
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7459
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7459
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7456
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7456
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7452
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7452
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7400
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7400
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7397
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7397
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7380
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7380
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7340
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7340
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7331
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7331
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7328
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7328
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7310
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7310
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7302
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7302
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7294
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7294
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7282
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7282
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7268
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7268
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7237
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7237
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7232
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7232
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7214
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7214
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7193
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7193
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7183
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7183
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7177
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7177
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7154
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7154
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7138
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7138
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7134
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7134
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7120
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7120
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7108
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7108
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7103
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7103
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.7095
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.7095
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7084
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7084
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7078
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7078
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7053
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7053
Putative b-glycan phosphorylase Q21MB1 Q21MB1_SACD2 Saccharophagus degradans 4 0.7035
Putative b-glycan phosphorylase Q21MB1 Q21MB1_SACD2 Saccharophagus degradans 4 0.7035
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7032
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7032
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7015
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7015
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7007
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7007

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