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(-)-isolariciresinol

Family: Plantae - Urticaceae
Kingdom: Plantae
Class: Lignan

Canonical Smiles	OC[C@H]1Cc2cc(OC)c(cc2[C@H]([C@@H]1CO)c1ccc(c(c1)OC)O)O
InChI	InChI=1S/C20H24O6/c1-25-18-6-11(3-4-16(18)23)20-14-8-17(24)19(26-2)7-12(14)5-13(9-21)15(20)10-22/h3-4,6-8,13,15,20-24H,5,9-10H2,1-2H3/t13-,15-,20-/m1/s1
InChIKey	OGFXBIXJCWAUCH-WAWZGNHOSA-N
Formula	C₂₀H₂₄O₆
HBA	6
HBD	4
MW	360.41
Rotatable Bonds	5
TPSA	99.38
LogP	2.02
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	26
Formal Charge	0
Fraction CSP3	0.4
Exact Mass	360.16
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Urtica dioica	Urticaceae	Plantae	3501

Showing of synonyms

Schöttner M, Reiner J, et al. (1997). Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Medica,1997,63(6),529-532. [View] [PubMed]

Pubchem: 1023563

Cas: 110268-37-6

Zinc: ZINC000000689725

Nmrshiftdb2: 60024963

Chembl: CHEMBL1760593

No compound-protein relationship available.

SMILES: c1cccc(c12)CCCC2c3ccccc3

Level: 1

Mol. Weight: 360.41 g/mol

SMILES: C1CCCc(c12)cccc2

Level: 0

Mol. Weight: 360.41 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 360.41 g/mol

Vasorelaxant

Absorption

Caco-2 (logPapp): -5.24
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.160
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.61

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.870
Plasma Protein Binding: 74.75
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 12.980
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.350
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.000
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 4.480
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Toxic
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -2.470
Rat (Acute): 2.110
Rat (Chronic Oral): 3.270
Fathead Minnow: 4.060
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 448.970
Hydration Free Energy: -9.840
Log(D) at pH=7.4: 1.930
Log(P): 0.72
Log S: -3.67
Log(Vapor Pressure): -8.05
Melting Point: 176.83
pKa Acid: 7.53
pKa Basic: 4.85

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.9319
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.9319
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9247
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9247
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9237
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9237
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9077
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9077
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.9052
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.9052
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8954
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8954
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8919
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8919
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.8852
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.8852
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8816
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8816
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8626
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8626
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8609
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8609
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8302
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8302
N-alpha-acetyltransferase 50	Q9GZZ1	NAA50_HUMAN	Homo sapiens	4	0.8259
N-alpha-acetyltransferase 50	Q9GZZ1	NAA50_HUMAN	Homo sapiens	4	0.8259
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8246
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8246
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8239
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8239
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.8226
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.8226
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8221
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8221
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8197
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8197
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8082
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8082
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8053
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8053
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.7989
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.7989
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	3	0.7945
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	3	0.7945
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	4	0.7925
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	4	0.7925
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7903
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7903
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7896
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7896
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.7891
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7891
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.7891
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7891
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7849
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7849
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7816
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7816
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7735
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7735
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7726
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7726
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7717
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7717
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7691
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7691
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7685
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7685
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	4	0.7678
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	4	0.7678
Dihydrofolate reductase type 1 from Tn4003	P13955	DYRA_STAAU	Staphylococcus aureus	4	0.7664
Dihydrofolate reductase type 1 from Tn4003	P13955	DYRA_STAAU	Staphylococcus aureus	4	0.7664
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7639
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7639
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7627
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7627
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7615
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7615
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7605
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7605
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.7565
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.7565
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7554
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7554
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7529
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7529
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7511
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7511
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7506
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7506
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	4	0.7467
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	4	0.7467
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7457
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7457
Adenosine monophosphate-protein transferase	Q8ZVF7	Q8ZVF7_PYRAE	Pyrobaculum aerophilum	4	0.7434
Adenosine monophosphate-protein transferase	Q8ZVF7	Q8ZVF7_PYRAE	Pyrobaculum aerophilum	4	0.7434
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7425
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7425
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7393
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7393
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7384
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7384
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7373
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7373
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7352
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7352
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7345
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7345
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7333
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7333
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7331
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7331
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.7321
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.7321
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7307
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7307
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7302
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7302
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7287
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7287
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7273
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7273
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7267
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7267
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7267
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7267
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7258
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7258
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7257
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7257
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7240
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7240
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7228
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7228
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7225
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7225
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7222
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7222
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7215
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7215
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.7200
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.7200
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7197
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7197
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	4	0.7192
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	4	0.7192
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7176
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7176
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7170
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7170
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7164
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7164
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7149
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7149
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7138
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7138
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7134
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7134
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7132
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7132
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7128
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7128
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7126
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7126
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7123
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7123
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.7110
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.7110
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7108
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7108
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7060
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7060
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7052
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7052
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7047
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7047
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7047
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7047
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7040
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7040
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7023
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7023
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7022
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7022
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.7016
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.7016
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7015
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7015
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7003
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7003

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