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Anhydrolycorine

Family: Plantae - Amaryllidaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Amaryllidaceae Alkaloid

Canonical Smiles	C1Oc2c(O1)cc1c(c2)CN2c3c1cccc3CC2
InChI	InChI=1S/C16H13NO2/c1-2-10-4-5-17-8-11-6-14-15(19-9-18-14)7-13(11)12(3-1)16(10)17/h1-3,6-7H,4-5,8-9H2
InChIKey	NWJBCDNATQJZOD-UHFFFAOYSA-N
Formula	C₁₆H₁₃NO₂
HBA	3
HBD	0
MW	251.28
Rotatable Bonds	0
TPSA	21.7
LogP	2.96
Number Rings	5
Number Aromatic Rings	2
Heavy Atom Count	19
Formal Charge	0
Fraction CSP3	0.25
Exact Mass	251.09
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Narcissus tazetta	Amaryllidaceae	Plantae	54860
2	Narcissus papyraceus	Amaryllidaceae	Plantae	54854

Showing of synonyms

Shawky E, Abou-Donia AH, et al. (2015). HPTLC and GC/MS study of Amaryllidaceae alkaloids of two Narcissus species. Chemistry and Biodiversity,2015,12(8),1184-1199. [View] [PubMed]

Pubchem: 619567

Cas: 641-89-4

Zinc: ZINC000032265412

Nmrshiftdb2: 60071269

Chembl: CHEMBL481250

No compound-protein relationship available.

SMILES: c1ccc(c2c13)c4c(CN2CC3)cc5c(c4)OCO5

Level: 0

Mol. Weight: 251.28 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.79
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.55
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -2.91

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.59
Plasma Protein Binding: 56.04
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 12.38
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.94
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.09
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.76
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: 4.97
Rat (Acute): 2.0
Rat (Chronic Oral): 1.31
Fathead Minnow: 4.58
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 411.14
Hydration Free Energy: -7.14
Log(D) at pH=7.4: 3.48
Log(P): 3.97
Log S: -4.25
Log(Vapor Pressure): -7.82
Melting Point: 160.87
pKa Acid: 12.44
pKa Basic: 5.38

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	3	0.9569
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	3	0.9569
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9525
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9525
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9498
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9498
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.9482
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.9482
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.9466
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.9466
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.9414
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.9414
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9364
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9364
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.9294
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.9294
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.9271
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.9271
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.9270
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.9270
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9246
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9246
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9207
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9207
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.9204
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.9204
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.9171
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.9171
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.9163
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.9163
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.9148
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.9148
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9147
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9147
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.9114
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.9114
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.9060
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.9060
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8998
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8998
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8995
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8995
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.8929
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.8929
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8911
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8911
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.8908
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.8908
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8862
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8862
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.8807
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.8807
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	3	0.8789
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	3	0.8789
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8761
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8761
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.8709
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.8709
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8703
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8703
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.8594
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.8594
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.8590
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.8590
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8562
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8562
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.8513
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.8513
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8482
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8482
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8400
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8400
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.8378
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.8378
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8355
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8355
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	3	0.8311
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	3	0.8311
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8305
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8305
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8286
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8286
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8268
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8268
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8266
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8266
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.8205
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.8205
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.8176
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.8176
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8173
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8173
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.8146
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.8146
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8126
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8126
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8120
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8120
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.8069
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.8069
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8041
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8041
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8033
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8033
Albumin	P02769	ALBU_BOVIN	Bos taurus	3	0.8021
Albumin	P02769	ALBU_BOVIN	Bos taurus	3	0.8021
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.8010
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.8010
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	3	0.8001
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	3	0.8001
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	2	0.7984
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	2	0.7984
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7983
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7983
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7978
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7978
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7969
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7969
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7945
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7945
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7939
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7939
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7935
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7935
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	3	0.7922
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	3	0.7922
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7902
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7902
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7870
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7870
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7844
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7844
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7828
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7828
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7811
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7811
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7782
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7782
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	3	0.7777
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	3	0.7777
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7774
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7774
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7768
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7768
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7744
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7744
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7718
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7718
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7707
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7707
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.7704
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.7704
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7694
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7694
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7671
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7671
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7648
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7648
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7631
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7631
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7622
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7622
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7621
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7621
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7603
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7603
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7596
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7596
Beta sliding clamp	P0A988	DPO3B_ECOLI	Escherichia coli	2	0.7562
Beta sliding clamp	P0A988	DPO3B_ECOLI	Escherichia coli	2	0.7562
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7555
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7555
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7546
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7546
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7536
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7536
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7536
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7536
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7531
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7531
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7531
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7531
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7530
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7530
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	3	0.7523
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	3	0.7523
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7509
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7509
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7504
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7504
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7486
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7486
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.7482
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.7482
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7476
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7476
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7473
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7473
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7456
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7456
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7455
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7455
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7447
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7447
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	2	0.7446
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	2	0.7446
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7443
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7443
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7437
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7437
Histamine N-methyltransferase	P50135	HNMT_HUMAN	Homo sapiens	3	0.7433
Histamine N-methyltransferase	P50135	HNMT_HUMAN	Homo sapiens	3	0.7433
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7426
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7426
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7422
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7422
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7418
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7418
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7402
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7402
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7401
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7401
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7399
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7399
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7394
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7394
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7389
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7389
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7388
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7388
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	2	0.7388
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	2	0.7388
Sterol 14alpha-demethylase	P9WPP9	CP51_MYCTU	Mycobacterium tuberculosis	3	0.7383
Sterol 14alpha-demethylase	P9WPP9	CP51_MYCTU	Mycobacterium tuberculosis	3	0.7383
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7380
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7380
Kynurenine 3-monooxygenase	P38169	KMO_YEAST	Saccharomyces cerevisiae	2	0.7378
Kynurenine 3-monooxygenase	P38169	KMO_YEAST	Saccharomyces cerevisiae	2	0.7378
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7366
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7366
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7365
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7365
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7360
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7360
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7358
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7358
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7357
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7357
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7354
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7354
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7354
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.7354
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	2	0.7354
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7354
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.7354
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	2	0.7354
Interleukin-2	P60568	IL2_HUMAN	Homo sapiens	2	0.7339
Interleukin-2	P60568	IL2_HUMAN	Homo sapiens	2	0.7339
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7327
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7327
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	2	0.7323
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	2	0.7323
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7320
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7320
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7320
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7320
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7315
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7315
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7308
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7308
Cell division cycle 7-related protein kinase	O00311	CDC7_HUMAN	Homo sapiens	3	0.7302
Cell division cycle 7-related protein kinase	O00311	CDC7_HUMAN	Homo sapiens	3	0.7302
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7301
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7301
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7291
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7291
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7287
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7287
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7282
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7282
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	3	0.7278
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	3	0.7278
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7250
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7250
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7249
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7249
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7241
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7241
Phospholipase A2, membrane associated	P14555	PA2GA_HUMAN	Homo sapiens	2	0.7227
Phospholipase A2, membrane associated	P14555	PA2GA_HUMAN	Homo sapiens	2	0.7227
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	2	0.7212
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	2	0.7212
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7204
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7204
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7203
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7203
Nitroreductase domain-containing protein	Q8DW21	Q8DW21_STRMU	Streptococcus mutans serotype c	3	0.7200
Nitroreductase domain-containing protein	Q8DW21	Q8DW21_STRMU	Streptococcus mutans serotype c	3	0.7200
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7194
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7194
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.7190
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.7190
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7184
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7184
Acetylcholine-binding protein	P58154	ACHP_LYMST	Lymnaea stagnalis	3	0.7180
Acetylcholine-binding protein	P58154	ACHP_LYMST	Lymnaea stagnalis	3	0.7180
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7175
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7175
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7175
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7175
Cytochrome P450 2D6	P10635	CP2D6_HUMAN	Homo sapiens	2	0.7168
Cytochrome P450 2D6	P10635	CP2D6_HUMAN	Homo sapiens	2	0.7168
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7165
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7165
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7164
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7164
Aryl hydrocarbon receptor nuclear translocator	P53762	ARNT_MOUSE	Mus musculus	3	0.7148
Aryl hydrocarbon receptor nuclear translocator	P53762	ARNT_MOUSE	Mus musculus	3	0.7148
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7133
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7133
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7129
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7129
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7126
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7126
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	2	0.7119
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	2	0.7119
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7118
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7118
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7109
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7109
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7109
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7109
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7108
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7108
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	2	0.7105
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	2	0.7105
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.7102
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.7102
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7097
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7097
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7096
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7096
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7096
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7096
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	2	0.7093
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	2	0.7093
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7084
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7084
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7081
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7081
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7081
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7081
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7081
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7081
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7076
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7076
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7069
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7069
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7068
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7068
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7067
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7067
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7062
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7062
transketolase	D2V4Z5	D2V4Z5_NAEGR	Naegleria gruberi	3	0.7060
transketolase	D2V4Z5	D2V4Z5_NAEGR	Naegleria gruberi	3	0.7060
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7052
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7052
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7050
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7050
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7047
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7047
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7032
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7032
Fatty acid-binding protein, adipocyte	P04117	FABP4_MOUSE	Mus musculus	2	0.7031
Fatty acid-binding protein, adipocyte	P04117	FABP4_MOUSE	Mus musculus	2	0.7031
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7029
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7029
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	2	0.7027
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	2	0.7027
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7022
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7022
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7012
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7012
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7010
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7010
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7010
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7010
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7008
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7008
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	2	0.7007
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	2	0.7007
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7005
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7005
Endolysin	P00720	ENLYS_BPT4	Enterobacteria phage T4	3	0.7003
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7003
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7003
Endolysin	P00720	ENLYS_BPT4	Enterobacteria phage T4	3	0.7003

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