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Galanthindole

Family: Plantae - Amaryllidaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Amaryllidaceae Alkaloid

Canonical Smiles	OCc1cc2OCOc2cc1c1cccc2c1n(C)cc2
InChI	InChI=1S/C17H15NO3/c1-18-6-5-11-3-2-4-13(17(11)18)14-8-16-15(20-10-21-16)7-12(14)9-19/h2-8,19H,9-10H2,1H3
InChIKey	YMAGZXPVILPRAP-UHFFFAOYSA-N
Formula	C₁₇H₁₅NO₃
HBA	4
HBD	1
MW	281.31
Rotatable Bonds	2
TPSA	43.62
LogP	3.07
Number Rings	4
Number Aromatic Rings	3
Heavy Atom Count	21
Formal Charge	0
Fraction CSP3	0.18
Exact Mass	281.11
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Narcissus tazetta	Amaryllidaceae	Plantae	54860

Showing of synonyms

Shawky E, Abou-Donia AH, et al. (2015). HPTLC and GC/MS study of Amaryllidaceae alkaloids of two Narcissus species. Chemistry and Biodiversity,2015,12(8),1184-1199. [View] [PubMed]

Pubchem: 71369229

Cas: 666174-48-7

Nmrshiftdb2: 60071270

Comptox: DTXSID90792260

No compound-protein relationship available.

SMILES: c1c[nH]c(c12)c(ccc2)-c(c3)ccc(c34)OCO4

Level: 1

Mol. Weight: 281.31 g/mol

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 281.31 g/mol

SMILES: c1c[nH]c(c12)cccc2

Level: 0

Mol. Weight: 281.31 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.82
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.31
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.07

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.45
Plasma Protein Binding: 73.6
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 10.23
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.66
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.35
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.04
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.08
Rat (Acute): 2.03
Rat (Chronic Oral): 1.72
Fathead Minnow: 4.78
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 427.36
Hydration Free Energy: -9.73
Log(D) at pH=7.4: 2.96
Log(P): 3.28
Log S: -3.68
Log(Vapor Pressure): -8.69
Melting Point: 147.53
pKa Acid: 10.14
pKa Basic: 3.05

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9258
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9258
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.9199
11-beta-hydroxysteroid dehydrogenase 1	Q6QLL4	DHI1_CAVPO	Cavia porcellus	3	0.9199
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.9092
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.9092
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9077
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.9077
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.9053
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.9053
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8986
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8986
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.8953
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.8953
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8943
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8943
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.8922
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.8922
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8885
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8885
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8849
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8849
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8774
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8774
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8745
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.8745
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8602
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8602
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.8583
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.8583
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8519
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8519
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8512
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8512
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8511
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8511
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8420
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8420
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.8319
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.8319
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8304
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8304
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.8286
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.8286
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8267
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8267
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.8250
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8250
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8250
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.8250
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8218
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8218
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8164
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8164
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.8149
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.8149
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	3	0.8094
glutaryl-CoA dehydrogenase (ETF)	Q3JP94	Q3JP94_BURP1	Burkholderia pseudomallei	3	0.8094
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.8064
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.8064
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.8061
Serine/threonine-protein kinase PLK2	Q9NYY3	PLK2_HUMAN	Homo sapiens	3	0.8061
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.8012
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	4	0.8012
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8008
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8008
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7935
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7935
HLA class I histocompatibility antigen, B alpha chain	P01889	HLAB_HUMAN	Homo sapiens	3	0.7919
HLA class I histocompatibility antigen, B alpha chain	P01889	HLAB_HUMAN	Homo sapiens	3	0.7919
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7902
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7902
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7898
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7898
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7876
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7876
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7846
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7846
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7830
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7830
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7819
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7819
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.7812
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.7812
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7803
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7803
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7773
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7773
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7771
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7771
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7727
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7727
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7703
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7703
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7693
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7693
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7692
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7692
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7679
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7679
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7665
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7665
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	4	0.7656
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	4	0.7656
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7612
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7612
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7602
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7602
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7594
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7594
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7584
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7584
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7546
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7546
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7534
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7534
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7534
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7534
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7533
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7533
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7512
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7512
Prostaglandin reductase 3	Q8N4Q0	PTGR3_HUMAN	Homo sapiens	3	0.7476
Prostaglandin reductase 3	Q8N4Q0	PTGR3_HUMAN	Homo sapiens	3	0.7476
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7468
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7468
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7452
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	3	0.7452
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7451
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7451
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7435
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7435
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7433
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7433
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.7391
Endoplasmin, putative	Q8I0V4	Q8I0V4_PLAF7	Plasmodium falciparum	4	0.7391
Endoplasmin, putative	Q8I0V4	Q8I0V4_PLAF7	Plasmodium falciparum	4	0.7391
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	4	0.7391
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7382
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7382
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7349
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7349
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7316
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7316
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7298
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7298
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	3	0.7288
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	3	0.7288
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.7277
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.7277
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7242
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7242
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7231
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7231
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	2	0.7221
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	2	0.7221
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7218
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7218
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7204
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7204
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.7198
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.7198
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	2	0.7165
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	2	0.7165
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7164
Actin-related protein 3	P61157	ARP3_BOVIN	Bos taurus	3	0.7164
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7163
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7163
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7161
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7161
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7154
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7154
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7152
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7152
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7133
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7133
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7133
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7133
Endolysin	P00720	ENLYS_BPT4	Enterobacteria phage T4	3	0.7131
Endolysin	P00720	ENLYS_BPT4	Enterobacteria phage T4	3	0.7131
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7111
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7111
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	3	0.7109
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	3	0.7109
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7107
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7107
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7103
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7103
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	3	0.7101
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	3	0.7101
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7083
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7083
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7079
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7079
F420-dependent NADP reductase	O29370	FNO_ARCFU	Archaeoglobus fulgidus	3	0.7073
F420-dependent NADP reductase	O29370	FNO_ARCFU	Archaeoglobus fulgidus	3	0.7073
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7064
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7064
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7058
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7058
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7051
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7051
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7047
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7047
Albumin	P02768	ALBU_HUMAN	Homo sapiens	4	0.7041
Albumin	P02768	ALBU_HUMAN	Homo sapiens	4	0.7041
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7038
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7038
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7036
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7036
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7027
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7027
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7018
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7018
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7015
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7015
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7008
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7008
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	3	0.7002
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	3	0.7002
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7001
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7001

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