2,8-dihydroxy-6-(hydroxymethyl)-1-methoxyanthracene-9,10-dione - Compound Card

2,8-dihydroxy-6-(hydroxymethyl)-1-methoxyanthracene-9,10-dione

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2,8-dihydroxy-6-(hydroxymethyl)-1-methoxyanthracene-9,10-dione

Structure
Zoomed Structure
  • Family: Plantae - Asphodelaceae
  • Kingdom: Plantae
  • Class: Quinone
    • Subclass: Anthraquinone
Canonical Smiles OCc1cc(O)c2c(c1)C(=O)c1c(C2=O)c(OC)c(cc1)O
InChI InChI=1S/C16H12O6/c1-22-16-10(18)3-2-8-13(16)15(21)12-9(14(8)20)4-7(6-17)5-11(12)19/h2-5,17-19H,6H2,1H3
InChIKey RTBAXLJYFRAIMK-UHFFFAOYSA-N
Formula C16H12O6
HBA 6
HBD 3
MW 300.27
Rotatable Bonds 2
TPSA 104.06
LogP 1.37
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 300.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Aloe sinkatana Asphodelaceae Plantae 210945
2 Aloe sinkatana Asphodelaceae Plantae 210945

Showing of synonyms

  • ELhassan GOM, Adhikari A, et al. (2011). Phytochemical and biological studies on Aloe sinkatana Berger. The 14th NAPRECA Symposium and AAMPS Ethnoveterinary Medicine Symposium, At Nairobi, Kenya. August 2011. [View]
  • ELhassan GOM, Adhikari A, et al. (2012). Phytochemistry and antiglycation activity of Aloe sinkatana Reynolds. Phytochemistry Letters,2012,5(4),725-728. [View]
Pubchem: 137918203

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)C(=O)c3c(C2=O)cccc3

Level: 0

Mol. Weight: 300.27 g/mol

Antiglycation

Absorption

Caco-2 (logPapp)
-4.83
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.79
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.35

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.79
Plasma Protein Binding
61.5
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.69
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.97
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.89
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.72
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.72
Rat (Acute)
2.38
Rat (Chronic Oral)
3.3
Fathead Minnow
4.13
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
447.32
Hydration Free Energy
-9.58
Log(D) at pH=7.4
1.41
Log(P)
1.98
Log S
-5.04
Log(Vapor Pressure)
-7.24
Melting Point
212.24
pKa Acid
7.28
pKa Basic
2.96
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9554
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9554
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.9287
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.9287
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9167
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9167
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8842
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8842
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8740
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8740
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8715
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8715
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8705
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8705
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8689
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8689
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8579
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8579
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8529
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8529
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8487
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8487
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8476
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8476
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8343
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8343
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8306
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8306
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8304
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8304
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8303
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8303
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8223
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8223
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8216
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8216
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8101
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8101
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8077
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8077
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.8074
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.8074
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8049
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8049
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8030
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8030
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7982
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7982
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7947
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7947
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7944
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7944
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7943
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7943
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7943
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7943
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7914
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7914
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7912
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7912
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.7912
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7912
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7912
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.7912
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7850
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7850
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7831
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7831
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7777
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7777
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7743
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7743
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7735
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7735
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7723
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7723
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7707
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7707
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7694
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7694
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7694
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7694
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7692
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7692
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7682
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7682
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7677
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7677
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7663
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7663
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7646
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7646
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7627
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7627
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7622
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7622
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7576
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7576
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7558
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7558
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7555
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7555
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7525
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7525
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7524
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7524
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7522
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7522
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7516
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7516
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7514
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7514
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 4 0.7494
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 4 0.7494
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7487
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7487
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7472
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7472
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7469
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7469
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7449
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7449
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7444
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7444
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7437
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7437
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7428
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7428
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7418
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7418
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7397
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7397
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7396
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7396
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7391
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7391
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7376
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7376
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7364
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7364
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7337
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7337
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7336
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7336
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7328
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7328
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7302
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7302
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7299
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7299
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7287
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7287
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7279
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7279
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7266
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7266
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7253
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7253
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7246
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7246
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7244
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7244
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7227
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7227
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7225
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7225
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7222
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7222
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7219
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7219
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7199
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7199
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7196
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7196
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7196
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7196
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7196
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7196
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7177
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7177
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7167
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7167
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7161
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7161
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7156
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7156
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7150
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7150
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7135
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7135
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7124
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7124
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7111
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7111
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7104
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7104
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7096
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7096
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7094
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7094
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7088
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7088
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7087
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7087
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7083
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7083
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7081
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7081
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7080
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7080
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7077
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7077
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7075
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7075
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7071
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7071
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7067
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7067
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7065
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7065
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7060
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7060
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7050
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7050
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7035
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7035
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7017
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7017

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