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Cinnamyl isovalerate

Family: Cupressaceae
Kingdom: Plantae
Class: Cinnamoyl Derivative

Canonical Smiles	CC(CC(=O)OC/C=C/c1ccccc1)C
InChI	InChI=1S/C14H18O2/c1-12(2)11-14(15)16-10-6-9-13-7-4-3-5-8-13/h3-9,12H,10-11H2,1-2H3/b9-6+
InChIKey	FOCMOGKCPPTERB-RMKNXTFCSA-N
Formula	C₁₄H₁₈O₂
HBA	2
HBD	0
MW	218.3
Rotatable Bonds	5
TPSA	26.3
LogP	3.29
Number Rings	1
Number Aromatic Rings	1
Heavy Atom Count	16
Formal Charge	0
Fraction CSP3	0.36
Exact Mass	218.13
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Juniperus species	Cupressaceae	Plantae	13100

Showing of synonyms

Barrero AF, Quılez del Moral JF, et al. (2004). Oxygenated diterpenes and other constituents from Moroccan Juniperus phoenicea and Juniperus thurifera var. africana. Phytochemistry,2004,65,2507-2515. [View] [PubMed]

Pubchem: 5355855

Cas: 140-27-2

Zinc: ZINC000001677811

Nmrshiftdb2: 60059066

Chembl: CHEMBL4162391

No compound-protein relationship available.

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.4
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.0
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.52

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.73
Plasma Protein Binding: 49.92
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 10.42
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.49
Biodegradation: Toxic
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 0.9
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.93
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.9
Rat (Acute): 1.69
Rat (Chronic Oral): 2.07
Fathead Minnow: 4.44
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 290.52
Hydration Free Energy: -4.58
Log(D) at pH=7.4: 4.11
Log(P): 4.03
Log S: -4.21
Log(Vapor Pressure): -2.78
Melting Point: 16.43
pKa Acid: 12.74
pKa Basic: 4.2

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.9718
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.9718
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9446
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9446
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.9057
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.9057
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.8499
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.8499
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.8478
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.8478
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.8276
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.8276
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8234
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8234
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8070
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8070
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.8053
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.8053
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.8023
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.8023
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7980
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7980
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7964
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7964
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7952
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7952
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7920
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7920
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7885
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7885
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7841
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7841
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7827
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7827
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	2	0.7782
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	2	0.7782
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7737
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7737
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7728
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7728
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7720
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7720
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	2	0.7718
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	2	0.7718
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7683
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7683
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7628
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7628
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7602
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7602
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7587
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7587
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7580
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7580
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	2	0.7577
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	2	0.7577
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7565
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7565
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7540
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7540
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7521
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7521
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	2	0.7520
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	2	0.7520
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7505
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7505
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7465
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7465
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7447
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7447
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7426
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7426
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7423
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7423
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7422
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7422
Cholesterol 24-hydroxylase	Q9Y6A2	CP46A_HUMAN	Homo sapiens	2	0.7404
Cholesterol 24-hydroxylase	Q9Y6A2	CP46A_HUMAN	Homo sapiens	2	0.7404
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7355
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7355
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7335
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7335
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7326
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7326
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7310
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7310
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7301
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7301
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7300
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7300
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7295
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7295
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7276
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7276
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7267
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7267
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7257
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7257
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7256
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7256
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7252
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7252
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7235
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7235
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7229
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7229
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	2	0.7224
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	2	0.7224
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7221
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7221
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7215
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7215
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7207
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7207
Alanine racemase	Q180W0	Q180W0_CLOD6	Clostridioides difficile	2	0.7204
Alanine racemase	Q180W0	Q180W0_CLOD6	Clostridioides difficile	2	0.7204
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7191
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7191
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7190
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7190
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7172
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7172
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	2	0.7164
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	2	0.7164
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	2	0.7156
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	2	0.7156
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	2	0.7137
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	2	0.7137
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	2	0.7130
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	2	0.7130
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7123
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7123
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7122
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7122
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7112
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7112
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7112
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7112
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7110
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7110
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7108
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7108
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	2	0.7105
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	2	0.7105
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7085
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7085
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7085
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7085
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7082
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7082
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7074
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7074
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	2	0.7052
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	2	0.7052
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7047
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7047
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7044
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7044
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	2	0.7038
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	2	0.7038
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	2	0.7033
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7033
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	2	0.7033
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7033
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7032
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7032
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7027
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7027
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	2	0.7019
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	2	0.7019
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7016
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7016
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7007
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7007

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