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5alpha-hydroxycostic acid
- Family: Plantae - Asteraceae
- Kingdom: Plantae
-
Class: Terpenoid
- Subclass: Sesquiterpene
| Canonical Smiles | OC(=O)C(=C)[C@@H]1CC[C@@]2([C@](C1)(O)C(=C)CCC2)C |
|---|---|
| InChI | InChI=1S/C15H22O3/c1-10-5-4-7-14(3)8-6-12(9-15(10,14)18)11(2)13(16)17/h12,18H,1-2,4-9H2,3H3,(H,16,17)/t12-,14-,15-/m1/s1 |
| InChIKey | UEQIFFFWXPAQCB-BPLDGKMQSA-N |
| Formula | C15H22O3 |
| HBA | 2 |
| HBD | 2 |
| MW | 250.34 |
| Rotatable Bonds | 2 |
| TPSA | 57.53 |
| LogP | 2.9 |
| Number Rings | 2 |
| Number Aromatic Rings | 0 |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Fraction CSP3 | 0.67 |
| Exact Mass | 250.16 |
| Number of Lipinski Rule Violations | 0 |
| # | Species | Family | Kingdom | NCBI Taxonomy ID |
|---|---|---|---|---|
| 1 | Chiliadenus montanus | Asteraceae | Plantae | 1458965 |
| 2 | Jasonia montana | Asteraceae | Plantae | 441235 |
| 3 | Pluchea dioscoridis | Asteraceae | Plantae | — |
| 4 | Tarchonanthus camphoratus | Asteraceae | Plantae | 41650 |
Showing of synonyms
5alpha-hydroxycostic acid
132185-83-2
5|A-Hydroxycostic acid
2-[(2R,4aR,8aR)-8a-hydroxy-4a-methyl-8-methylidene-2,3,4,5,6,7-hexahydro-1H-naphthalen-2-yl]prop-2-enoic acid
5-Hydroxycostic acid
2-((2R,4AR,8aR)-8a-hydroxy-4a-methyl-8-methylenedecahydronaphthalen-2-yl)acrylic acid
HY-N2666
AKOS032961618
FS-10298
PD200011
CS-0023098
(2R,4aR,8aR)-Decahydro-8a-hydroxy-4a-methyl-,8-bis(methylene)-2-naphthaleneacetic acid
- Mahmoud AA (1997). 7-Epi-eudesmanes, eudesmanoic acids, eudesmanolides and other sesquiterpenenes from Pluchea dioscoridis. Phytochemistry,1997,45(8),1633-1638. [View]
- Hegazy MEF, Matsuda H, et al. (2014). Chemical constituents and their antibacterial and antifungal activity from the Egyptian herbal medicine Chiliadenus montanus. Phytochemistry,2014,103,154-161. [View] [PubMed]
- Ahmed AA, Jakupovic J (1990). Sesqui- and monoterpenes from Jasonia montana. Phytochemistry,1990,29(11),3658-3661. [View]
- Hegazy MEF, Tawfik WA, et al. (2015). Sesquiterpene acid derivatives from Tarchonanthus camphoratus. Research Journal of Pharmaceutical, Biological and Chemical Sciences,2015,6(1),659-663. [View]
No compound-protein relationship available.
SMILES: C=C1CCCC(C12)CCCC2
Level: 0
Mol. Weight: 250.34 g/mol
Antimicrobial
Absorption
- Caco-2 (logPapp)
- -4.71
- Human Oral Bioavailability 20%
- Bioavailable
- Human Intestinal Absorption
- Absorbed
- Madin-Darby Canine Kidney
- -4.54
- Human Oral Bioavailability 50%
- Non-Bioavailable
- P-Glycoprotein Inhibitor
- Non-Inhibitor
- P-Glycoprotein Substrate
- Non-Substrate
- Skin Permeability
- -2.05
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Penetrable
- Fraction Unbound (Human)
- 0.46
- Plasma Protein Binding
- 54.01
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Non-Substrate
- CYP 2C19 Inhibitor
- Non-Inhibitor
- CYP 2C19 Substrate
- Non-Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Non-Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Non-Inhibitor
Excretion
- Clearance
- 4.09
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Safe
- Bee
- Toxic
- Bioconcentration Factor
- -0.5
- Biodegradation
- Safe
- Carcinogenesis
- Safe
- Crustacean
- Safe
- Liver Injury I (DILI)
- Safe
- Eye Corrosion
- Safe
- Eye Irritation
- Toxic
- Maximum Tolerated Dose
- 0.17
- Liver Injury II
- Toxic
- hERG Blockers
- Safe
- Daphnia Maga
- 3.38
- Micronucleos
- Safe
- NR-AhR
- Safe
- NR-AR
- Safe
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- -0.01
- Rat (Acute)
- 2.36
- Rat (Chronic Oral)
- 2.22
- Fathead Minnow
- 3.92
- Respiratory Disease
- Safe
- Skin Sensitisation
- Toxic
- SR-ARE
- Safe
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 325.81
- Hydration Free Energy
- -7.68
- Log(D) at pH=7.4
- 0.24
- Log(P)
- 2.9
- Log S
- -2.8
- Log(Vapor Pressure)
- -6.04
- Melting Point
- 141.26
- pKa Acid
- 3.94
- pKa Basic
- 9.22
| Protein Name | UniProt ID | Entry Name | Species | #Pharmacophore Points | Probability (0.7 ≤ Tversky Score ≤ 1.0) |
|---|---|---|---|---|---|
| Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 3 | 0.9497 |
| Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 3 | 0.9497 |
| Prostaglandin reductase 2 | Q8N8N7 | PTGR2_HUMAN | Homo sapiens | 3 | 0.9309 |
| Prostaglandin reductase 2 | Q8N8N7 | PTGR2_HUMAN | Homo sapiens | 3 | 0.9309 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.9288 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.9288 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9093 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9093 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.8981 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.8981 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8931 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8931 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.8925 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.8925 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.8913 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.8913 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8909 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8909 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8877 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8877 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.8803 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.8803 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.8667 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.8667 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8607 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8607 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8542 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8542 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.8503 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.8503 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8462 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8462 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8060 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8060 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.7955 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.7955 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.7937 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.7937 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7836 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7836 |
| ADP-ribosylation factor 1 | P84080 | ARF1_BOVIN | Bos taurus | 3 | 0.7805 |
| ADP-ribosylation factor 1 | P84080 | ARF1_BOVIN | Bos taurus | 3 | 0.7805 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7787 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7787 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7780 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7780 |
| Pentaerythritol tetranitrate reductase | P71278 | P71278_ENTCL | Enterobacter cloacae | 3 | 0.7748 |
| Pentaerythritol tetranitrate reductase | P71278 | P71278_ENTCL | Enterobacter cloacae | 3 | 0.7748 |
| Phospholipase A2, major isoenzyme | P00592 | PA21B_PIG | Sus scrofa | 3 | 0.7742 |
| Phospholipase A2, major isoenzyme | P00592 | PA21B_PIG | Sus scrofa | 3 | 0.7742 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7733 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7733 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7702 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7702 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7696 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7696 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7676 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7676 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7672 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7672 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7665 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7665 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7656 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7656 |
| Sulfotransferase 2A1 | Q06520 | ST2A1_HUMAN | Homo sapiens | 3 | 0.7655 |
| Sulfotransferase 2A1 | Q06520 | ST2A1_HUMAN | Homo sapiens | 3 | 0.7655 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7641 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7641 |
| Nuclear receptor subfamily 1 group I member 3 | O35627 | NR1I3_MOUSE | Mus musculus | 2 | 0.7605 |
| Nuclear receptor subfamily 1 group I member 3 | O35627 | NR1I3_MOUSE | Mus musculus | 2 | 0.7605 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.7603 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.7603 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7595 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7595 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7580 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7580 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7572 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7572 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7562 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7562 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7556 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7556 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7539 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7539 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7535 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7535 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7534 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7534 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7523 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7523 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7489 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7489 |
| Soluble cytochrome b562 | P0ABE7 | C562_ECOLX | Escherichia coli | 2 | 0.7483 |
| Soluble cytochrome b562 | P0ABE7 | C562_ECOLX | Escherichia coli | 2 | 0.7483 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7482 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7482 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7479 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7479 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7473 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7473 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7470 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7470 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7452 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7452 |
| Sulfotransferase 2A1 | Q06520 | ST2A1_HUMAN | Homo sapiens | 3 | 0.7438 |
| Sulfotransferase 2A1 | Q06520 | ST2A1_HUMAN | Homo sapiens | 3 | 0.7438 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7437 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7437 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7431 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7431 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7428 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7428 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7428 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7428 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7424 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7424 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7418 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7418 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7413 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7413 |
| Androgen receptor | P19091 | ANDR_MOUSE | Mus musculus | 3 | 0.7404 |
| Androgen receptor | P19091 | ANDR_MOUSE | Mus musculus | 3 | 0.7404 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7402 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7402 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7395 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7395 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7371 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7371 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7362 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7362 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7357 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7357 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.7336 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.7336 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.7333 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.7333 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7329 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7329 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7325 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7325 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7306 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7306 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7295 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7295 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7291 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7291 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7287 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7287 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7254 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7254 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7235 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7235 |
| Neocarzinostatin | P0A3R9 | NCZS_STRCZ | Streptomyces carzinostaticus | 2 | 0.7222 |
| Neocarzinostatin | P0A3R9 | NCZS_STRCZ | Streptomyces carzinostaticus | 2 | 0.7222 |
| Sulfotransferase 2A1 | Q06520 | ST2A1_HUMAN | Homo sapiens | 2 | 0.7209 |
| Sulfotransferase 2A1 | Q06520 | ST2A1_HUMAN | Homo sapiens | 2 | 0.7209 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7200 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7200 |
| Avidin | P02701 | AVID_CHICK | Gallus gallus | 3 | 0.7193 |
| Avidin | P02701 | AVID_CHICK | Gallus gallus | 3 | 0.7193 |
| Glucocorticoid receptor | P04150 | GCR_HUMAN | Homo sapiens | 3 | 0.7185 |
| Glucocorticoid receptor | P04150 | GCR_HUMAN | Homo sapiens | 3 | 0.7185 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7145 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7145 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7136 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7136 |
| Retinoic acid receptor RXR-alpha | P19793 | RXRA_HUMAN | Homo sapiens | 3 | 0.7084 |
| Retinoic acid receptor RXR-alpha | P19793 | RXRA_HUMAN | Homo sapiens | 3 | 0.7084 |
| Nuclear receptor ROR-gamma | P51449 | RORG_HUMAN | Homo sapiens | 2 | 0.7059 |
| Nuclear receptor ROR-gamma | P51449 | RORG_HUMAN | Homo sapiens | 2 | 0.7059 |
| NPC intracellular cholesterol transporter 1 | O15118 | NPC1_HUMAN | Homo sapiens | 3 | 0.7037 |
| NPC intracellular cholesterol transporter 1 | O15118 | NPC1_HUMAN | Homo sapiens | 3 | 0.7037 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7022 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7022 |