Apigenin-7-O-malonyl glucoside - Compound Card

Apigenin-7-O-malonyl glucoside

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Apigenin-7-O-malonyl glucoside

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone Glycoside
Canonical Smiles [O-]C(=O)CC(=O)OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)c2ccc(cc2)O)[C@@H]([C@H]([C@@H]1O)O)O
InChI InChI=1S/C24H22O13/c25-11-3-1-10(2-4-11)15-7-14(27)20-13(26)5-12(6-16(20)36-15)35-24-23(33)22(32)21(31)17(37-24)9-34-19(30)8-18(28)29/h1-7,17,21-26,31-33H,8-9H2,(H,28,29)/p-1/t17-,21-,22+,23-,24-/m1/s1
InChIKey JXWAQRJFONLTSI-ASDZUOGYSA-M
Formula C24H21O13-
HBA 13
HBD 5
MW 517.42
Rotatable Bonds 7
TPSA 216.25
LogP -1.26
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 37
Formal Charge -1
Fraction CSP3 0.29
Exact Mass 517.1
Number of Lipinski Rule Violations 2
# Species Family Kingdom NCBI Taxonomy ID
1 Cynara cardunculus Asteraceae Plantae 4265

Showing of synonyms

  • Farag MA, El-Ahmady SH, et al. (2013). Metabolomics driven analysis of artichoke leaf and its commercial products via UHPLC–q-TOF-MS and chemometrics. Phytochemistry,2013,95,177-187. [View] [PubMed]
Pubchem: 25202906

No compound-protein relationship available.

Structure

SMILES: c1ccccc1-c(cc2=O)oc(c23)cc(cc3)OC4CCCCO4

Level: 2

Mol. Weight: 517.42 g/mol

Structure

SMILES: O=c1ccoc(c12)cc(cc2)OC3CCCCO3

Level: 1

Mol. Weight: 517.42 g/mol

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 517.42 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 517.42 g/mol

Structure

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 517.42 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 517.42 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-7.04
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Non-Absorbed
Madin-Darby Canine Kidney
-5.13
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
0.08

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.13
Plasma Protein Binding
84.66
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.15
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
-1.4
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.02
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.34
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-689.22
Rat (Acute)
2.18
Rat (Chronic Oral)
3.91
Fathead Minnow
4.98
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
604.6
Hydration Free Energy
-3.25
Log(D) at pH=7.4
-0.6
Log(P)
0.6
Log S
-4.37
Log(Vapor Pressure)
-11.99
Melting Point
218.99
pKa Acid
5.89
pKa Basic
5.13
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9576
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9576
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9499
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9499
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9338
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9338
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9282
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9282
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9278
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9278
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9179
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9179
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9038
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9038
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.9022
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.9022
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8940
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8940
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8876
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8876
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8833
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8833
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8831
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8831
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8791
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8791
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8760
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8760
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8634
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8634
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8582
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8582
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8579
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8579
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8559
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8559
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.8488
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.8488
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8483
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8483
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8480
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8480
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8458
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8458
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8411
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8411
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.8390
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.8390
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8380
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8380
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8366
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8366
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8359
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8359
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8339
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8339
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8325
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8325
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8317
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8317
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8304
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8304
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8304
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8304
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8279
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8279
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8261
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8261
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8258
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8258
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8248
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8248
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 3 0.8230
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 3 0.8230
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8221
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8221
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8198
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8198
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8196
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8196
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8176
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8176
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8176
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8176
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 4 0.8164
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 4 0.8164
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8131
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8131
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8113
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8113
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8081
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8081
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 4 0.8066
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 4 0.8066
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8044
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8044
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8033
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8033
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8029
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8029
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8011
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8011
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8006
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8006
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8005
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8005
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8002
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8002
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7984
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7984
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 4 0.7964
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 4 0.7964
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7963
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7963
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7953
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7953
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 3 0.7951
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 3 0.7951
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7949
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7949
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7943
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7943
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7939
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7939
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7924
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7924
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7908
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7908
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7897
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7897
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7883
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7883
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7878
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7878
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7809
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7809
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7778
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7778
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7777
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7777
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7774
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7774
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7743
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7743
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7722
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7722
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7706
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7706
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7679
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7679
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7634
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7634
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7627
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7627
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7611
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7611
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7604
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7604
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7578
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7578
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7558
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7558
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7555
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7555
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7545
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7545
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7526
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7526
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7520
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7520
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7502
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7502
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7491
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7491
Mitogen-activated protein kinase kinase kinase 21 Q5TCX8 M3K21_HUMAN Homo sapiens 3 0.7466
Mitogen-activated protein kinase kinase kinase 21 Q5TCX8 M3K21_HUMAN Homo sapiens 3 0.7466
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7459
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7459
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7440
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7440
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7439
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7439
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7353
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7353
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7346
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7346
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7344
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7344
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7336
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7336
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7319
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7319
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7313
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7313
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7312
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7312
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7309
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7309
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7308
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7308
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7295
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7295
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7273
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7273
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 4 0.7265
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 4 0.7265
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7258
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7258
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7255
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7255
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7254
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7254
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7242
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7242
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7239
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7239
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7229
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7229
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7224
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7224
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7222
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7222
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7213
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7213
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7212
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7212
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7209
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7209
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7209
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7209
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7202
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7202
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7202
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7202
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7194
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7194
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7193
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7193
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7179
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7179
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7178
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7178
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7174
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7174
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7173
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7173
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7171
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7171
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7165
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7165
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7164
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7164
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7163
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7163
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7162
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7162
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7160
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7160
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7148
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7148
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7140
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7140
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7133
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7133
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7132
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7132
Histone H3 P61830 H3_YEAST Saccharomyces cerevisiae 2 0.7131
Histone H3 P61830 H3_YEAST Saccharomyces cerevisiae 2 0.7131
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7128
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7128
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7121
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7121
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7108
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7108
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7094
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7094
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7062
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7062
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7047
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7047
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7045
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7045
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7044
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7044
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7040
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7040
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7039
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7039
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7034
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7034
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7033
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7033
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7013
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7013
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7012
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7012
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7012
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7012
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7011
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7011
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7008
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7008
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7004
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7004
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7004
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7004
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7001
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7001

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