Luteolin-7-O-acetyl-glucoside - Compound Card

Luteolin-7-O-acetyl-glucoside

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Luteolin-7-O-acetyl-glucoside

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone Glycoside
Canonical Smiles CC(=O)OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)c2ccc(c(c2)O)O)[C@@H]([C@H]([C@@H]1O)O)O
InChI InChI=1S/C23H22O12/c1-9(24)32-8-18-20(29)21(30)22(31)23(35-18)33-11-5-14(27)19-15(28)7-16(34-17(19)6-11)10-2-3-12(25)13(26)4-10/h2-7,18,20-23,25-27,29-31H,8H2,1H3/t18-,20-,21+,22-,23-/m1/s1
InChIKey BURUDCAXNNYPGK-DODNOZFWSA-N
Formula C23H22O12
HBA 12
HBD 6
MW 490.42
Rotatable Bonds 5
TPSA 196.35
LogP 0.33
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 35
Formal Charge 0
Fraction CSP3 0.3
Exact Mass 490.11
Number of Lipinski Rule Violations 2
# Species Family Kingdom NCBI Taxonomy ID
1 Cynara scolymus Asteraceae Plantae 59895

Showing of synonyms

  • El Senousy AS, Farag MA, et al. (2014). Developmental changes in leaf phenolics composition from three artichoke cvs. (Cynara scolymus) as determined via UHPLC–MS and chemometrics. Phytochemistry,2014,108,67-76. [View] [PubMed]
Pubchem: 21721976
Nmrshiftdb2: 60023802

No compound-protein relationship available.

Structure

SMILES: c1ccccc1-c(cc2=O)oc(c23)cc(cc3)OC4CCCCO4

Level: 2

Mol. Weight: 490.42 g/mol

Structure

SMILES: O=c1ccoc(c12)cc(cc2)OC3CCCCO3

Level: 1

Mol. Weight: 490.42 g/mol

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 490.42 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 490.42 g/mol

Structure

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 490.42 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 490.42 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-6.79
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Non-Absorbed
Madin-Darby Canine Kidney
-5.13
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
0.34

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.99
Plasma Protein Binding
85.08
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
13.81
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
-1.44
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.11
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.12
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-265.24
Rat (Acute)
2.28
Rat (Chronic Oral)
3.84
Fathead Minnow
4.26
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
607.34
Hydration Free Energy
-3.62
Log(D) at pH=7.4
1.16
Log(P)
0.84
Log S
-4.88
Log(Vapor Pressure)
-11.68
Melting Point
217.03
pKa Acid
6.19
pKa Basic
5.6
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9620
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9620
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9407
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9407
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.9396
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.9396
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9346
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9346
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9276
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9276
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.9115
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.9115
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9100
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9100
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.9068
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.9068
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9056
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9056
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9048
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9048
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8955
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8955
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8935
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8935
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8924
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8924
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.8824
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.8824
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8770
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8770
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8745
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8745
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8701
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8701
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8678
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8678
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8665
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8665
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8627
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8627
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8624
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8624
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8557
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8557
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8552
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8552
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8442
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8442
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8404
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8404
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8377
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8377
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8371
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8371
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8369
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8369
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8368
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8368
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8364
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8364
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8363
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8363
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8329
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8329
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8310
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8310
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.8301
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.8301
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8265
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8265
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8245
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8245
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8244
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8244
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8221
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8221
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8218
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8218
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8215
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8215
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8208
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8208
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8201
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8201
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8200
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8200
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8200
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8200
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8187
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8187
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8107
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8107
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8102
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8102
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8099
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8099
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.8075
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.8075
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8034
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8034
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8031
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8031
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8028
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8028
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8002
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8002
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.7998
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.7998
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7953
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7953
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7952
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7952
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7949
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7949
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7895
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7895
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7868
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7868
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7831
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7831
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7828
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7828
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7823
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7823
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7796
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7796
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7791
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7791
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7781
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7781
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7778
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7778
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7765
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7765
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7760
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7760
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7758
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7758
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7701
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7701
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7699
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7699
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7697
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7697
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7684
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7684
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7681
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7681
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7679
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7679
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7626
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7626
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7616
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7616
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7613
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7613
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7611
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7611
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7606
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7606
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7604
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7604
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7601
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7601
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7585
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7585
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7568
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7568
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7559
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7559
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7550
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7550
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7531
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7531
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7525
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7525
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7481
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7481
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7476
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7476
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7472
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7472
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7471
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7471
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7469
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7469
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7459
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7459
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7458
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7458
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7450
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7450
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7449
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7449
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7446
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7446
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7419
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7419
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7414
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7414
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7400
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7400
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7381
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7381
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7380
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7380
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7370
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7370
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 4 0.7346
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 4 0.7346
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7344
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7344
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7344
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7344
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7343
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7343
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7327
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7327
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7321
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7321
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7320
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7320
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7313
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7313
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7312
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7312
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7302
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7302
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7301
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7301
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7300
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7300
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7295
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7295
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7294
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7294
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7291
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7291
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7286
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7286
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7283
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7283
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7267
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7267
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7265
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7265
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7254
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7254
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7251
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7251
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7243
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7243
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7240
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7240
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7213
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7213
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7212
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7212
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7207
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7207
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7199
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7199
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7196
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7196
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7182
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7182
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7178
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7178
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7159
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7159
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7145
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7145
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7143
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7143
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7140
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7140
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7139
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7139
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7133
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7133
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7122
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7122
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7115
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7115
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.7114
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.7114
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7104
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7104
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7096
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7096
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7096
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7096
Histone-arginine methyltransferase CARM1 Q4AE70 CARM1_RAT Rattus norvegicus 4 0.7095
Histone-arginine methyltransferase CARM1 Q4AE70 CARM1_RAT Rattus norvegicus 4 0.7095
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7093
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7093
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7092
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7092
DNA-(apurinic or apyrimidinic site) lyase Q97FM4 Q97FM4_CLOAB Clostridium acetobutylicum 4 0.7090
DNA-(apurinic or apyrimidinic site) lyase Q97FM4 Q97FM4_CLOAB Clostridium acetobutylicum 4 0.7090
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7089
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7089
Ribosomal protein L11 methyltransferase, putative C3MWA1 C3MWA1_SULIM Sulfolobus islandicus 4 0.7080
Ribosomal protein L11 methyltransferase, putative C3MWA1 C3MWA1_SULIM Sulfolobus islandicus 4 0.7080
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7080
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7080
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7075
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7075
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7074
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7074
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7073
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7073
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7073
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7073
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7064
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7064
Methyltransferase protein Q5LFK0 Q5LFK0_BACFN Bacteroides fragilis 4 0.7061
Methyltransferase protein Q5LFK0 Q5LFK0_BACFN Bacteroides fragilis 4 0.7061
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.7059
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.7059
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7055
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7055
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7054
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7054
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7052
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7052
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7050
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7050
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.7047
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.7047
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7046
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7046
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7046
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7046
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7041
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7041
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7041
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7041
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7039
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7039
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7031
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7031
Trimethylamine dehydrogenase P16099 DHTM_METME Methylophilus methylotrophus 4 0.7030
Methyltransferase domain-containing protein O57965 O57965_PYRHO Pyrococcus horikoshii 4 0.7030
Trimethylamine dehydrogenase P16099 DHTM_METME Methylophilus methylotrophus 4 0.7030
Methyltransferase domain-containing protein O57965 O57965_PYRHO Pyrococcus horikoshii 4 0.7030
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7025
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7025
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7024
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7024
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7016
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7016
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7016
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7016
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7015
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7015
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7007
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7007
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7007
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7007

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