3-(10-hydroxygeranyl)-4-hydroxy-p-coumaric acid - Compound Card

3-(10-hydroxygeranyl)-4-hydroxy-p-coumaric acid

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3-(10-hydroxygeranyl)-4-hydroxy-p-coumaric acid

Structure
Zoomed Structure
  • Family: Asteraceae-Compositae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles C/C(=C\Cc1cc(/C=C/C(=O)O)ccc1O)/CC/C=C(/COC(=O)C)\C
InChI InChI=1S/C21H26O5/c1-15(5-4-6-16(2)14-26-17(3)22)7-10-19-13-18(8-11-20(19)23)9-12-21(24)25/h6-9,11-13,23H,4-5,10,14H2,1-3H3,(H,24,25)/b12-9+,15-7+,16-6+
InChIKey ISUNOKDROKKZDY-DGOHTRLXSA-N
Formula C21H26O5
HBA 4
HBD 2
MW 358.43
Rotatable Bonds 9
TPSA 83.83
LogP 4.27
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.33
Exact Mass 358.18
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Chrysothamnus viscidiflorus Asteraceae-Compositae Plantae 72914

Showing of synonyms

  • Ahmed AA, Hegazy MEF, et al. (2006). Constituents of Chrysothamnus viscidiflorus. Phytochemistry,2006,67,1547-1553. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.9
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.78
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.75

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.48
Plasma Protein Binding
42.84
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.09
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.11
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.14
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
3.72
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.47
Rat (Acute)
1.76
Rat (Chronic Oral)
2.75
Fathead Minnow
5.04
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
407.08
Hydration Free Energy
-8.25
Log(D) at pH=7.4
1.22
Log(P)
4.72
Log S
-4.63
Log(Vapor Pressure)
-8.14
Melting Point
159.42
pKa Acid
8.23
pKa Basic
6.15
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9728
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9728
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase P12995 BIOA_ECOLI Escherichia coli 3 0.9531
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase P12995 BIOA_ECOLI Escherichia coli 3 0.9531
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9441
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9441
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9367
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9367
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9298
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9298
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9266
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9266
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.9240
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.9240
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9229
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9229
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.9176
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9176
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9176
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.9176
Feruloyl esterase A O42807 FAEA_ASPNG Aspergillus niger 3 0.9130
Feruloyl esterase A O42807 FAEA_ASPNG Aspergillus niger 3 0.9130
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9123
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9123
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.9103
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.9103
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9100
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9100
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9065
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9065
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8998
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8998
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 4 0.8969
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 4 0.8969
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8941
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8941
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8894
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8894
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8882
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8882
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 3 0.8826
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 3 0.8826
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8792
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8792
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 3 0.8759
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 3 0.8759
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8729
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8729
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8667
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8667
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8661
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8661
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8631
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8631
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8627
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8627
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8626
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8626
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8625
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8625
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8602
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8602
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8510
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8510
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8476
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8476
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8464
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8464
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8418
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8418
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8346
Caffeic acid 3-O-methyltransferase P28002 COMT1_MEDSA Medicago sativa 3 0.8346
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8346
Caffeic acid 3-O-methyltransferase P28002 COMT1_MEDSA Medicago sativa 3 0.8346
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8333
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8333
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8317
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8317
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.8299
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.8299
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8282
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8282
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.8232
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.8232
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8192
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8192
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8188
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8188
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.8185
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.8185
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8168
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8168
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8164
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8164
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8160
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8160
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8135
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8135
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 3 0.8090
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 3 0.8090
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 4 0.8041
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 4 0.8041
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8020
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8020
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8013
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8013
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7999
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7999
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7997
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7997
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7929
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7929
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 4 0.7917
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 4 0.7917
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7892
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7892
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7890
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7890
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7862
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7862
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7804
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7804
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7793
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7793
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7789
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7789
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7772
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7772
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 3 0.7757
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 3 0.7757
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7745
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7745
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7733
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7733
Casein kinase I isoform gamma-2 P78368 KC1G2_HUMAN Homo sapiens 3 0.7731
Casein kinase I isoform gamma-2 P78368 KC1G2_HUMAN Homo sapiens 3 0.7731
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7728
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7728
Replication factor C subunit 1 P38630 RFC1_YEAST Saccharomyces cerevisiae 4 0.7721
Replication factor C subunit 1 P38630 RFC1_YEAST Saccharomyces cerevisiae 4 0.7721
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7707
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7707
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7676
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7676
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase P9WNH5 HSAD_MYCTU Mycobacterium tuberculosis 3 0.7650
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase P9WNH5 HSAD_MYCTU Mycobacterium tuberculosis 3 0.7650
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7643
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7643
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7605
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7605
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7604
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7604
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7600
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7600
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7590
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7590
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7588
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7588
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7586
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7586
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7585
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7585
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7576
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7576
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7569
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7569
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7560
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7560
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7546
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7546
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7512
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7512
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7494
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7494
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7490
Malate synthase G P9WK17 MASZ_MYCTU Mycobacterium tuberculosis 3 0.7490
Malate synthase G P9WK17 MASZ_MYCTU Mycobacterium tuberculosis 3 0.7490
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7490
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7486
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7486
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7477
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7477
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7477
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7477
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7474
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7474
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7474
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7474
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7466
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7466
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7461
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7461
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7458
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7458
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7456
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7456
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7452
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7452
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7449
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7449
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7435
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7435
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7419
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7419
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7417
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7417
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7412
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7412
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7412
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7412
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7409
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7409
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7404
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7404
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7402
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7402
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7399
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7399
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7363
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7363
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7362
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7362
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7361
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7361
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 2 0.7355
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 2 0.7355
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7351
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7351
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7348
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7348
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7348
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7348
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7346
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7346
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7345
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7345
5-formyltetrahydrofolate cyclo-ligase P75430 MTHFS_MYCPN Mycoplasma pneumoniae 2 0.7344
5-formyltetrahydrofolate cyclo-ligase P75430 MTHFS_MYCPN Mycoplasma pneumoniae 2 0.7344
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7342
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7342
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.7337
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7337
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7337
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.7337
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7335
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7335
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7323
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7323
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7320
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7320
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7319
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7319
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7318
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7318
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7318
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7318
thiamine diphosphokinase Q82ZE3 Q82ZE3_ENTFA Enterococcus faecalis 3 0.7317
thiamine diphosphokinase Q82ZE3 Q82ZE3_ENTFA Enterococcus faecalis 3 0.7317
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7313
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7313
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 3 0.7304
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 3 0.7304
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.7302
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.7302
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7291
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7291
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7287
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7287
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7284
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7284
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7281
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7281
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7280
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7280
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7278
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7278
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7277
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7277
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7273
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7273
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7271
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7271
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7269
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7269
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7267
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7267
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7260
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7260
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7258
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7258
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7254
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7254
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7253
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7253
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7248
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7248
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7245
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7245
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7243
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7243
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 3 0.7238
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 3 0.7238
Major NAD(P)H-flavin oxidoreductase P46072 FRA1_ALIFS Aliivibrio fischeri 2 0.7229
Major NAD(P)H-flavin oxidoreductase P46072 FRA1_ALIFS Aliivibrio fischeri 2 0.7229
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7226
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7226
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7226
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7226
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7223
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7223
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7222
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7222
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7221
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7221
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7214
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7214
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7213
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7213
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7212
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7212
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7212
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7212
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7211
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7211
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7210
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7210
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7208
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7208
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7208
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7208
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7205
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7205
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7201
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7201
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7199
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7199
Serine/threonine-protein kinase PLK Q4KMI8 Q4KMI8_DANRE Danio rerio 3 0.7198
Serine/threonine-protein kinase PLK Q4KMI8 Q4KMI8_DANRE Danio rerio 3 0.7198
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7185
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7185
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7180
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7180
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7177
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7177
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7174
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7174
ATP-dependent helicase/nuclease subunit A P23478 ADDA_BACSU Bacillus subtilis 2 0.7169
ATP-dependent helicase/nuclease subunit A P23478 ADDA_BACSU Bacillus subtilis 2 0.7169
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7159
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7159
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7159
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 3 0.7159
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7155
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7155
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7155
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7155
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7152
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7152
Carnitine O-acetyltransferase P47934 CACP_MOUSE Mus musculus 2 0.7150
Carnitine O-acetyltransferase P47934 CACP_MOUSE Mus musculus 2 0.7150
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7149
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7149
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7141
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7141
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7138
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7138
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7137
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7137
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7136
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7136
Serine/threonine-protein kinase RIO1 Q9BRS2 RIOK1_HUMAN Homo sapiens 3 0.7135
Serine/threonine-protein kinase RIO1 Q9BRS2 RIOK1_HUMAN Homo sapiens 3 0.7135
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7133
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7133
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7133
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7133
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7132
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7132
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.7130
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.7130
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7126
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7126
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7114
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7114
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7112
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7112
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7107
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7107
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7107
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7107
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7105
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7105
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7105
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7105
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7104
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7104
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7103
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7103
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7103
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7103
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7103
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7103
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7098
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7098
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7097
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7097
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7095
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7095
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7090
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7090
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7080
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7080
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7079
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7079
Virginiamycin A acetyltransferase P26839 VATA_STAAU Staphylococcus aureus 3 0.7077
Virginiamycin A acetyltransferase P26839 VATA_STAAU Staphylococcus aureus 3 0.7077
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7068
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7068
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7066
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7066
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7063
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7063
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7057
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7057
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7048
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7048
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7040
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7040
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7038
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7038
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7037
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7037
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7036
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7036
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7019
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7019
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7018
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7018
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7014
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7014
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 4 0.7012
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 4 0.7012
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7008
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7008
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7004
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7004

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