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Isorhamnetin 3-sulphate

Family: Plantae - Asteraceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Flavonol Sulphate

Canonical Smiles	COc1cc(ccc1[O-])c1oc2cc(O)cc(c2c(=O)c1OS(=O)(=O)[O-])O
InChI	InChI=1S/C16H12O10S/c1-24-11-4-7(2-3-9(11)18)15-16(26-27(21,22)23)14(20)13-10(19)5-8(17)6-12(13)25-15/h2-6,17-19H,1H3,(H,21,22,23)/p-2
InChIKey	CZFNXFXZXWDYMZ-UHFFFAOYSA-L
Formula	C₁₆H₁₀O₁₀S-₂
HBA	10
HBD	2
MW	394.31
Rotatable Bonds	4
TPSA	169.39
LogP	0.79
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	27
Formal Charge	-2
Fraction CSP3	0.06
Exact Mass	394.0
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Conyza dioscoridis	Asteraceae	Plantae	264977
2	Senecio gallicus	Asteraceae	Plantae	121545
3	Senecio hoggariensis	Asteraceae	Plantae	352207

Showing of synonyms

Mansour RMA, Saleh NAM (1981). Flavonoids of three local Senecio species. Phytochemistry, 1981,20(5),1180-1181. [View]
Ahmed AA, Meek FR, et al. (1987). Sulfated and non-sulfated flavonoids from Pluchea dioscoridis. Journal of Natural Products,1987,50(2),311. [View]

Pubchem: 44123491

No compound-protein relationship available.

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 394.31 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 394.31 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 394.31 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.47
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.400
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -4.97

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.200
Plasma Protein Binding: 82.1
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 8.890
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.240
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.470
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.390
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 6.990
Rat (Acute): 2.220
Rat (Chronic Oral): 1.560
Fathead Minnow: 3.950
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 549.320
Hydration Free Energy: -5.040
Log(D) at pH=7.4: -0.190
Log(P): 1.83
Log S: -2.51
Log(Vapor Pressure): -11.17
Melting Point: 265.16
pKa Acid: 6.57
pKa Basic: 0.51

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.9170
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.9170
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.9122
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.9122
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9018
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9018
Ribosomal protein S6 kinase alpha-3	P18654	KS6A3_MOUSE	Mus musculus	6	0.8874
Ribosomal protein S6 kinase alpha-3	P18654	KS6A3_MOUSE	Mus musculus	6	0.8874
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	3	0.8814
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	3	0.8814
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8810
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8810
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8750
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8750
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8747
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8747
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8641
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8641
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8616
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8616
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8572
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8572
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	4	0.8472
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	4	0.8472
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.8455
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.8455
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8451
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8451
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.8382
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.8382
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	5	0.8364
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	5	0.8364
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.8330
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.8330
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8328
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.8328
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8286
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8286
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8270
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	6	0.8245
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	6	0.8245
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8235
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8235
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8230
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8230
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8200
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8200
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8163
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8163
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.8122
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.8122
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8054
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8054
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8001
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8001
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8000
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8000
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	4	0.7982
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	4	0.7982
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7978
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7978
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7957
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7957
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7947
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7947
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.7943
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	3	0.7943
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7909
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7909
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7850
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7850
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7837
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7837
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7828
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7828
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7804
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7804
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7783
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7783
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.7771
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.7771
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7770
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7770
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7718
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7718
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7702
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7702
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7677
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7677
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	4	0.7676
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	4	0.7676
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	5	0.7614
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	5	0.7614
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7598
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7598
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7582
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7582
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7582
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7582
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7580
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7580
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7577
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7577
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7576
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7576
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7511
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7511
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7462
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7462
Prostaglandin reductase 3	Q8N4Q0	PTGR3_HUMAN	Homo sapiens	3	0.7459
Prostaglandin reductase 3	Q8N4Q0	PTGR3_HUMAN	Homo sapiens	3	0.7459
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7428
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7428
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7411
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7411
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	3	0.7408
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	3	0.7408
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	3	0.7395
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	3	0.7395
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7341
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7341
Maltokinase	A1TH50	MAK_MYCVP	Mycolicibacterium vanbaalenii	3	0.7336
Maltokinase	A1TH50	MAK_MYCVP	Mycolicibacterium vanbaalenii	3	0.7336
Ribosomal protein S6 kinase alpha-3	P18654	KS6A3_MOUSE	Mus musculus	7	0.7326
Ribosomal protein S6 kinase alpha-3	P18654	KS6A3_MOUSE	Mus musculus	7	0.7326
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7310
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7310
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7306
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7306
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7301
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7301
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	4	0.7272
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	4	0.7272
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.7270
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.7270
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7257
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7257
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7255
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7255
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7199
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7199
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7197
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7197
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7175
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7175
5-formyltetrahydrofolate cyclo-ligase	P75430	MTHFS_MYCPN	Mycoplasma pneumoniae	2	0.7175
5-formyltetrahydrofolate cyclo-ligase	P75430	MTHFS_MYCPN	Mycoplasma pneumoniae	2	0.7175
Cytosolic IMP-GMP specific 5'-nucleotidase	Q5ZZB6	Q5ZZB6_LEGPH	Legionella pneumophila subsp. pneumophila	4	0.7167
Cytosolic IMP-GMP specific 5'-nucleotidase	Q5ZZB6	Q5ZZB6_LEGPH	Legionella pneumophila subsp. pneumophila	4	0.7167
Kinesin heavy chain	Q41460	Q41460_SOLTU	Solanum tuberosum	3	0.7149
Kinesin heavy chain	Q41460	Q41460_SOLTU	Solanum tuberosum	3	0.7149
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7138
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7138
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7117
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7117
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7103
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7103
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7102
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7102
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7079
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7079
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	4	0.7023
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	4	0.7023
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7019
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7019

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