5,3'-dihydroxy-6,7,4'-trimethoxyflavone - Compound Card

5,3'-dihydroxy-6,7,4'-trimethoxyflavone

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5,3'-dihydroxy-6,7,4'-trimethoxyflavone

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone Aglycone
Canonical Smiles COc1cc2oc(cc(=O)c2c(c1OC)O)c1ccc(c(c1)O)OC
InChI InChI=1S/C18H16O7/c1-22-12-5-4-9(6-10(12)19)13-7-11(20)16-14(25-13)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3
InChIKey KLAOKWJLUQKWIF-UHFFFAOYSA-N
Formula C18H16O7
HBA 7
HBD 2
MW 344.32
Rotatable Bonds 4
TPSA 98.36
LogP 2.9
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 344.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Centaurea granata Asteraceae Plantae 479585

Showing of synonyms

  • Medjroubi K, Benayache F, et al. (1998). Eudesmanolide from Centaurea granata. Phytochemistry,1998,49(8),2425-2427. [View]
CPRiL: 104409
Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 344.32 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 344.32 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 344.32 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.58
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.910
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.37

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.470
Plasma Protein Binding
84.23
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.320
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.980
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.480
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.050
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.920
Rat (Acute)
2.240
Rat (Chronic Oral)
2.750
Fathead Minnow
4.940
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
457.350
Hydration Free Energy
-10.390
Log(D) at pH=7.4
3.500
Log(P)
2.72
Log S
-5.69
Log(Vapor Pressure)
-7.51
Melting Point
191.32
pKa Acid
7.71
pKa Basic
3.22
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9820
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9820
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9723
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9723
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9695
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9695
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9629
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9629
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9454
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9454
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9418
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9418
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9416
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9416
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9332
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9332
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9296
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9296
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9274
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9274
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9216
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9216
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9205
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9205
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9200
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9200
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9188
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9188
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9138
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9138
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9129
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9129
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.9112
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.9112
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9082
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9082
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8997
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8997
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8987
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8987
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8975
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8975
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8922
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8922
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8922
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8922
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.8899
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.8899
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8894
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8894
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8843
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8843
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8841
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8841
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8839
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8839
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8829
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8829
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8822
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8822
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8819
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8819
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8794
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8794
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8786
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8786
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8779
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8779
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8774
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8774
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8773
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8773
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8758
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8758
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8735
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8735
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8732
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8732
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8729
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8729
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8729
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8729
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8708
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8708
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8682
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8682
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8675
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8675
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8671
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8671
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8665
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8665
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8651
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8651
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8638
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8638
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8600
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8600
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8599
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8599
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8572
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8572
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8557
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8557
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8556
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8556
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8546
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8546
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8514
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8514
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.8506
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.8506
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8474
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8474
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8473
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8473
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8447
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8447
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8425
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8425
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8413
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8413
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8397
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8397
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.8389
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.8389
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8375
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8375
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8369
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8369
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8358
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8358
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.8349
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.8349
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8339
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8339
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8304
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8304
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.8303
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.8303
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8298
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8298
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8295
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8295
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8265
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8265
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8253
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8253
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8242
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8242
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8225
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8225
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8222
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8222
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8219
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8219
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.8210
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.8210
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8190
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8190
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8174
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8174
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8163
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8163
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8147
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8147
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8133
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8133
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8129
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8129
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8121
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8121
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8120
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8120
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8086
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8086
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8076
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8076
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8076
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8076
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8049
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8049
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.8046
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8046
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8046
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.8046
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8030
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8030
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7977
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7977
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7977
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7977
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7955
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7955
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7952
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7952
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 4 0.7943
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 4 0.7943
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7939
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7939
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7906
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7906
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7889
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7889
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7879
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7879
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7877
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7877
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7873
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7873
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7855
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7855
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7853
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7853
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7846
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7846
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7829
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7829
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7826
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7826
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7821
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7821
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7820
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7820
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7819
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7819
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.7797
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.7797
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7787
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7787
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7786
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7786
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7782
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7782
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7776
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7776
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7765
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7765
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7761
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7761
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7730
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7730
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7722
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7722
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7718
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7718
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7718
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7718
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7706
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7706
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7702
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7702
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7695
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7695
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7682
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7682
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7678
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7678
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7657
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7657
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7656
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7656
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7628
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7628
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7607
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7607
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7606
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7606
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7590
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7590
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7589
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7589
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7589
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7589
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7555
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7555
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7555
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7555
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7543
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7543
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7529
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7529
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7514
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7514
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7511
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7511
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7501
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7501
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7489
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7489
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7478
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7478
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7474
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7474
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7463
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7463
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7456
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7456
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7455
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7455
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7455
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7455
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7454
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7454
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7449
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7449
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7449
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7449
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7442
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7442
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7440
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7440
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7435
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7435
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7429
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7429
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7421
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7421
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7416
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7416
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7411
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7411
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic Q9FYS3 HGGL_SECCE Secale cereale 3 0.7403
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic Q9FYS3 HGGL_SECCE Secale cereale 3 0.7403
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7400
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7400
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7394
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7394
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7393
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7393
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7393
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7393
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7386
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7386
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7377
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7377
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7375
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7375
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7367
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7367
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7364
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7364
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7360
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7360
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7360
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7360
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7346
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7346
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7345
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7345
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7342
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7342
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7341
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7341
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7339
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7339
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7330
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7330
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7328
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7328
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7328
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7328
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7311
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7311
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7311
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7311
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7309
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7309
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7306
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7306
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7303
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7303
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7301
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7301
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7297
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7297
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7293
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7293
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7289
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7289
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7289
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7289
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7279
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7279
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7277
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7277
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7277
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7277
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7271
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7271
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7259
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7259
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7243
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7243
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7241
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7241
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7237
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7237
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7230
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7230
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7229
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7229
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7227
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7227
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.7227
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 4 0.7227
Biphenyl-2,3-diol 1,2-dioxygenase P47228 BPHC_PARXL Paraburkholderia xenovorans 3 0.7224
Biphenyl-2,3-diol 1,2-dioxygenase P47228 BPHC_PARXL Paraburkholderia xenovorans 3 0.7224
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7219
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7219
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7214
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7214
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7212
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7212
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7207
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7207
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7195
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7195
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7192
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7192
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7183
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7183
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7182
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7182
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7174
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7174
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7174
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7174
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7169
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7169
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7158
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7158
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7156
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7156
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7155
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7155
Nucleoside diphosphate kinase Q9U1E1 Q9U1E1_LEIMA Leishmania major 3 0.7152
Nucleoside diphosphate kinase Q9U1E1 Q9U1E1_LEIMA Leishmania major 3 0.7152
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7146
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7146
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7146
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7146
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7145
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7145
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7145
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7145
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7142
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7142
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7138
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7138
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7131
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7131
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7126
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7126
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7125
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7125
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7116
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7116
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7113
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7113
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7112
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7112
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 4 0.7105
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 4 0.7105
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7103
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7103
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7102
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7102
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7101
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7101
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7099
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7099
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7097
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7097
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7095
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7095
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7087
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7087
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7078
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7078
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7072
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7072
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7057
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7057
Tryptophan--tRNA ligase Q9PIB4 SYW_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7055
Tryptophan--tRNA ligase Q9PIB4 SYW_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 4 0.7055
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7053
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7053
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7052
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7052
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7051
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7051
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7051
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7051
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7049
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7049
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7048
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7048
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7044
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7044
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7037
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7037
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7033
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7033
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7027
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7027
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7023
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7023
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7022
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7022
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7011
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7011
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7007
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7007

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