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Costic acid
- Family: Plantae - Asteraceae
- Kingdom: Plantae
-
Class: Terpenoid
- Subclass: Sesquiterpene
| Canonical Smiles | C=C1CCC[C@]2([C@H]1C[C@@H](CC2)C(=C)C(=O)O)C |
|---|---|
| InChI | InChI=1S/C15H22O2/c1-10-5-4-7-15(3)8-6-12(9-13(10)15)11(2)14(16)17/h12-13H,1-2,4-9H2,3H3,(H,16,17)/t12-,13+,15-/m1/s1 |
| InChIKey | UJQGVDNQDFTTLZ-VNHYZAJKSA-N |
| Formula | C15H22O2 |
| HBA | 1 |
| HBD | 1 |
| MW | 234.34 |
| Rotatable Bonds | 2 |
| TPSA | 37.3 |
| LogP | 3.79 |
| Number Rings | 2 |
| Number Aromatic Rings | 0 |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Fraction CSP3 | 0.67 |
| Exact Mass | 234.16 |
| Number of Lipinski Rule Violations | 0 |
| # | Species | Family | Kingdom | NCBI Taxonomy ID |
|---|---|---|---|---|
| 1 | Dittrichia graveolens | Asteraceae | Plantae | 1532790 |
| 2 | Jasonia montana | Asteraceae | Plantae | 441235 |
Showing of synonyms
Costic acid
3650-43-9
Beta-Costic acid
Costus acid
UNII-6109CN8DDD
6109CN8DDD
Eudesma-4(14),11(13)-dien-12-oic acid
2-Naphthaleneacetic acid, decahydro-4a-methyl-alpha,8-bis(methylene)-, (2R-(2alpha,4aalpha,8abeta))-
2-NAPHTHALENEACETIC ACID, 1,2beta,3,4,4A,5,6,7,8,8Abeta-DECAHYDRO-4Aalpha-METHYL-alpha,8-DIMETHYLENE-
2-NAPHTHALENEACETIC ACID, DECAHYDRO-4A-METHYL-alpha,8-BIS(METHYLENE)-, (2R,4AR,8AS)-
2-[(2R,4aR,8aS)-4a-methyl-8-methylidene-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]prop-2-enoic acid
Cosstic acid
Beta-Costicacid
-Costic acid
.BETA.-COSTIC ACID
CHEMBL486398
DTXSID50190001
CHEBI:196135
HY-N2927
AKOS032948521
FS-9811
FC141815
CS-0023540
Q27263263
2-((2R,4aR,8aS)-4a-Methyl-8-methylenedecahydronaphthalen-2-yl)acrylic acid
2-NAPHTHALENEACETIC ACID, 1,2.BETA.,3,4,4A,5,6,7,8,8A.BETA.-DECAHYDRO-4A.ALPHA.-METHYL-.ALPHA.,8-DIMETHYLENE-
2-NAPHTHALENEACETIC ACID, DECAHYDRO-4A-METHYL-.ALPHA.,8-BIS(METHYLENE)-, (2R,4AR,8AS)-
2-NAPHTHALENEACETIC ACID, DECAHYDRO-4A-METHYL-.ALPHA.,8-BIS(METHYLENE)-, (2R-(2.ALPHA.,4A.ALPHA.,8A.BETA.))-
- Ahmed AA, Jakupovic J, et al. (1988). 11-Hydroxyjasionone, a new sesquiterpene type from Jasonia montana. Phytochemistry,1988,27(12),3875-3877. [View]
- Abou-Douh AM (2008). New eudesmane derivatives and other sesquiterpenes from the epigeal parts of Dittrichia graveolens. Chemical and Pharmaceutical Bulletin,2008,56(11),1535-1545. [View] [PubMed]
Pubchem:
6451579
Cas:
3650-43-9
Zinc:
ZINC000033985877
Chebi:
196135
Nmrshiftdb2:
60022695
Chembl:
CHEMBL486398
Comptox:
DTXSID50190001
CPRiL:
420307
SMILES: C=C1CCCC(C12)CCCC2
Level: 0
Mol. Weight: 234.34 g/mol
No bioactivities available.
Absorption
- Caco-2 (logPapp)
- -4.58
- Human Oral Bioavailability 20%
- Bioavailable
- Human Intestinal Absorption
- Absorbed
- Madin-Darby Canine Kidney
- -4.42
- Human Oral Bioavailability 50%
- Non-Bioavailable
- P-Glycoprotein Inhibitor
- Non-Inhibitor
- P-Glycoprotein Substrate
- Non-Substrate
- Skin Permeability
- -2.48
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Penetrable
- Fraction Unbound (Human)
- 0.74
- Plasma Protein Binding
- 63.82
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Non-Substrate
- CYP 2C19 Inhibitor
- Inhibitor
- CYP 2C19 Substrate
- Non-Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Non-Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Non-Inhibitor
Excretion
- Clearance
- 3.73
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Safe
- Bee
- Toxic
- Bioconcentration Factor
- 0.23
- Biodegradation
- Safe
- Carcinogenesis
- Safe
- Crustacean
- Safe
- Liver Injury I (DILI)
- Safe
- Eye Corrosion
- Safe
- Eye Irritation
- Toxic
- Maximum Tolerated Dose
- -0.32
- Liver Injury II
- Toxic
- hERG Blockers
- Safe
- Daphnia Maga
- 3.22
- Micronucleos
- Safe
- NR-AhR
- Safe
- NR-AR
- Safe
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- 0.57
- Rat (Acute)
- 2.66
- Rat (Chronic Oral)
- 2.3
- Fathead Minnow
- 3.92
- Respiratory Disease
- Toxic
- Skin Sensitisation
- Toxic
- SR-ARE
- Toxic
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 314.53
- Hydration Free Energy
- -4.59
- Log(D) at pH=7.4
- 1.6
- Log(P)
- 4.33
- Log S
- -4.01
- Log(Vapor Pressure)
- -5.16
- Melting Point
- 114.14
- pKa Acid
- 5.08
- pKa Basic
- 8.64
| Protein Name | UniProt ID | Entry Name | Species | #Pharmacophore Points | Probability (0.7 ≤ Tversky Score ≤ 1.0) |
|---|---|---|---|---|---|
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.9169 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.9169 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9129 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9129 |
| Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 3 | 0.9111 |
| Prostaglandin reductase 2 | Q8N8N7 | PTGR2_HUMAN | Homo sapiens | 3 | 0.9111 |
| Prostaglandin reductase 2 | Q8N8N7 | PTGR2_HUMAN | Homo sapiens | 3 | 0.9111 |
| Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 3 | 0.9111 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9110 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9110 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.9104 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.9104 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9052 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9052 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9043 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9043 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9007 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9007 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8987 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8987 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.8882 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.8882 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8791 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8791 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8646 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8646 |
| Pentaerythritol tetranitrate reductase | P71278 | P71278_ENTCL | Enterobacter cloacae | 3 | 0.8644 |
| Pentaerythritol tetranitrate reductase | P71278 | P71278_ENTCL | Enterobacter cloacae | 3 | 0.8644 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8630 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8630 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8542 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8542 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8423 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8423 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8287 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8287 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.8066 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.8066 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.8051 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.8051 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7838 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7838 |
| ADP-ribosylation factor 1 | P84080 | ARF1_BOVIN | Bos taurus | 3 | 0.7836 |
| ADP-ribosylation factor 1 | P84080 | ARF1_BOVIN | Bos taurus | 3 | 0.7836 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7811 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7811 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7764 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7764 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7762 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7762 |
| Methylketone synthase I | E0YCS2 | E0YCS2_SOLHA | Solanum habrochaites | 2 | 0.7758 |
| Methylketone synthase I | E0YCS2 | E0YCS2_SOLHA | Solanum habrochaites | 2 | 0.7758 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7693 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7693 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7680 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7680 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7677 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7677 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7655 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7655 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7648 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7648 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7641 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7641 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7635 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7635 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7625 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7625 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7609 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7609 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7603 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7603 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7599 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7599 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7587 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7587 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7582 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7582 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7579 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7579 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 2 | 0.7578 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 2 | 0.7578 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7577 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7577 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7574 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7574 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7568 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7568 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7565 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7565 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.7558 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.7558 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7555 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7555 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7555 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7555 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7553 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7553 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7551 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7551 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7550 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7550 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7548 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7548 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7546 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7546 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7545 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7545 |
| Androgen receptor | P19091 | ANDR_MOUSE | Mus musculus | 3 | 0.7535 |
| Androgen receptor | P19091 | ANDR_MOUSE | Mus musculus | 3 | 0.7535 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7534 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7534 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7533 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7533 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7533 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7533 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7532 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7532 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7530 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7530 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.7522 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.7522 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7521 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7521 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7518 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7518 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7515 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7515 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7507 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7507 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7505 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7505 |
| Phospholipase A2, major isoenzyme | P00592 | PA21B_PIG | Sus scrofa | 3 | 0.7503 |
| Phospholipase A2, major isoenzyme | P00592 | PA21B_PIG | Sus scrofa | 3 | 0.7503 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7484 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7484 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7481 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7481 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7470 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7470 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7467 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7467 |
| Phospholipase A2 | P00593 | PA21B_BOVIN | Bos taurus | 3 | 0.7447 |
| Phospholipase A2 | P00593 | PA21B_BOVIN | Bos taurus | 3 | 0.7447 |
| Nuclear receptor subfamily 1 group I member 3 | O35627 | NR1I3_MOUSE | Mus musculus | 2 | 0.7431 |
| Nuclear receptor subfamily 1 group I member 3 | O35627 | NR1I3_MOUSE | Mus musculus | 2 | 0.7431 |
| Retinoic acid receptor RXR-alpha | P19793 | RXRA_HUMAN | Homo sapiens | 3 | 0.7423 |
| Retinoic acid receptor RXR-alpha | P19793 | RXRA_HUMAN | Homo sapiens | 3 | 0.7423 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7419 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7419 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7406 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7406 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7386 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7386 |
| Soluble cytochrome b562 | P0ABE7 | C562_ECOLX | Escherichia coli | 2 | 0.7383 |
| Soluble cytochrome b562 | P0ABE7 | C562_ECOLX | Escherichia coli | 2 | 0.7383 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7325 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7325 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7310 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7310 |
| NPC intracellular cholesterol transporter 1 | O15118 | NPC1_HUMAN | Homo sapiens | 3 | 0.7305 |
| NPC intracellular cholesterol transporter 1 | O15118 | NPC1_HUMAN | Homo sapiens | 3 | 0.7305 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7283 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7283 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7264 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7264 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.7258 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.7258 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 2 | 0.7243 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 2 | 0.7243 |
| Ferrochelatase, mitochondrial | P22830 | HEMH_HUMAN | Homo sapiens | 2 | 0.7224 |
| Ferrochelatase, mitochondrial | P22830 | HEMH_HUMAN | Homo sapiens | 2 | 0.7224 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 2 | 0.7209 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 2 | 0.7209 |
| Sulfotransferase 2A1 | Q06520 | ST2A1_HUMAN | Homo sapiens | 3 | 0.7203 |
| Sulfotransferase 2A1 | Q06520 | ST2A1_HUMAN | Homo sapiens | 3 | 0.7203 |
| Glucocorticoid receptor | P04150 | GCR_HUMAN | Homo sapiens | 3 | 0.7198 |
| Glucocorticoid receptor | P04150 | GCR_HUMAN | Homo sapiens | 3 | 0.7198 |
| Avidin | P02701 | AVID_CHICK | Gallus gallus | 3 | 0.7189 |
| Avidin | P02701 | AVID_CHICK | Gallus gallus | 3 | 0.7189 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7187 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7187 |
| Sulfotransferase 2A1 | Q06520 | ST2A1_HUMAN | Homo sapiens | 2 | 0.7148 |
| Sulfotransferase 2A1 | Q06520 | ST2A1_HUMAN | Homo sapiens | 2 | 0.7148 |
| Neocarzinostatin | P0A3R9 | NCZS_STRCZ | Streptomyces carzinostaticus | 2 | 0.7107 |
| Neocarzinostatin | P0A3R9 | NCZS_STRCZ | Streptomyces carzinostaticus | 2 | 0.7107 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7040 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7040 |