4-chloro-2-(hepta-1,3,5-triyn-1-yl)-phenol - Compound Card

4-chloro-2-(hepta-1,3,5-triyn-1-yl)-phenol

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4-chloro-2-(hepta-1,3,5-triyn-1-yl)-phenol

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles CC#CC#CC#Cc1cc(Cl)ccc1O
InChI InChI=1S/C13H7ClO/c1-2-3-4-5-6-7-11-10-12(14)8-9-13(11)15/h8-10,15H,1H3
InChIKey MCEZMEUDXFRABM-UHFFFAOYSA-N
Formula C13H7ClO
HBA 1
HBD 1
MW 214.65
Rotatable Bonds 0
TPSA 20.23
LogP 2.42
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 15
Formal Charge 0
Fraction CSP3 0.08
Exact Mass 214.02
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Helichrysum aureonitens Asteraceae Plantae 1244806

Showing of synonyms

  • Ziaratnia SM, Ohyama K, et al. (2009). Isolation and identification of a novel chlorophenol from a cell suspension culture of Helichrysum aureonitens. Chemical and Pharmaceutical Bulletin,2009,57(11),1282-1283. [View] [PubMed]
Pubchem: 44521557

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 214.65 g/mol

Antitubercular
Cytotoxic

Absorption

Caco-2 (logPapp)
-4.25
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.42
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.89

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.2
Plasma Protein Binding
74.22
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.41
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.76
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Toxic
Eye Irritation
Toxic
Maximum Tolerated Dose
0.67
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
6.79
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Toxic
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
7.49
Rat (Acute)
3.47
Rat (Chronic Oral)
1.59
Fathead Minnow
4.64
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
325.57
Hydration Free Energy
-4.78
Log(D) at pH=7.4
5.12
Log(P)
5.32
Log S
-3.73
Log(Vapor Pressure)
-4.07
Melting Point
117.2
pKa Acid
8.2
pKa Basic
-0.83
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 3 0.8436
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 3 0.8436
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8367
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8367
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8176
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8176
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7785
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7785
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7718
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7718
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7714
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7714
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7697
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7697
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7604
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7604
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7544
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7544
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7543
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7543
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7488
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7488
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7457
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7457
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7416
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7416
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7398
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7398
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7392
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7392
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7388
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7388
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7378
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7378
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7361
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7361
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7358
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7358
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7349
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7349
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7344
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7344
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7340
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7340
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7329
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7329
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7326
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7326
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7320
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7320
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7317
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7317
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7310
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7310
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7296
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7296
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7295
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7295
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7294
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7294
Chorismate pyruvate-lyase P26602 UBIC_ECOLI Escherichia coli 2 0.7292
Chorismate pyruvate-lyase P26602 UBIC_ECOLI Escherichia coli 2 0.7292
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7286
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7286
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7267
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7267
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7262
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7262
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7255
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7255
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7252
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7252
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7250
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7250
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7249
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7249
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7248
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7248
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7247
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7247
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7247
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7247
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7244
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7244
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7240
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7240
Tryptophan synthase beta chain 2 Q97TX6 TRPB2_SACS2 Saccharolobus solfataricus 2 0.7238
Tryptophan synthase beta chain 2 Q97TX6 TRPB2_SACS2 Saccharolobus solfataricus 2 0.7238
LL-diaminopimelate aminotransferase, chloroplastic Q93ZN9 DAPAT_ARATH Arabidopsis thaliana 2 0.7236
LL-diaminopimelate aminotransferase, chloroplastic Q93ZN9 DAPAT_ARATH Arabidopsis thaliana 2 0.7236
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7233
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7233
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7230
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7230
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7229
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7229
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7227
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7227
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7224
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7224
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7221
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7221
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7212
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7212
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7205
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7205
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7201
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7201
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7201
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7201
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7198
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7198
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7191
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7191
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7188
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7188
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7187
Aspartate carbamoyltransferase catalytic subunit P0A786 PYRB_ECOLI Escherichia coli 2 0.7187
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7185
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7185
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7185
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7185
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7179
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7179
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7178
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7178
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7177
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7177
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7177
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7177
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7175
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7175
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 2 0.7169
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 2 0.7169
Class B acid phosphatase P0AE22 APHA_ECOLI Escherichia coli 2 0.7164
Class B acid phosphatase P0AE22 APHA_ECOLI Escherichia coli 2 0.7164
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7161
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7161
adenine phosphoribosyltransferase Q967M2 Q967M2_GIAIN Giardia intestinalis 2 0.7154
adenine phosphoribosyltransferase Q967M2 Q967M2_GIAIN Giardia intestinalis 2 0.7154
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7153
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7153
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7152
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7152
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7149
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7149
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7147
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7147
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7146
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7146
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 2 0.7146
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 2 0.7146
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7144
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7144
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7142
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7142
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7133
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7133
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7132
Seed lectin subunit I P05045 LEC1_VIGUC Vigna unguiculata subsp. cylindrica 2 0.7132
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7132
Seed lectin subunit I P05045 LEC1_VIGUC Vigna unguiculata subsp. cylindrica 2 0.7132
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7131
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7131
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7129
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7129
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7126
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7126
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7124
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7124
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7123
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7123
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 2 0.7119
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 2 0.7119
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7115
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7115
Aspartate aminotransferase P00509 AAT_ECOLI Escherichia coli 2 0.7107
Aspartate aminotransferase P00509 AAT_ECOLI Escherichia coli 2 0.7107
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7105
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7105
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7097
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7097
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7097
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7097
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7096
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7096
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7094
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7094
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7090
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7090
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7086
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7086
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7083
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7083
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7082
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7082
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7077
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7077
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7076
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.7076
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7076
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.7076
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7075
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7075
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7072
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7072
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7072
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7072
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7071
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7071
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7070
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7070
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7065
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7065
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 2 0.7062
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 2 0.7062
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 O95340 PAPS2_HUMAN Homo sapiens 2 0.7059
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 O95340 PAPS2_HUMAN Homo sapiens 2 0.7059
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 2 0.7057
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 2 0.7057
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7056
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7056
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 2 0.7054
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7054
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7054
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7054
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7054
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 2 0.7054
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7048
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7048
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7046
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7046
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7043
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7043
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 2 0.7042
Purine nucleoside phosphorylase, putative A2E7Y6 A2E7Y6_TRIVA Trichomonas vaginalis 2 0.7042
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7041
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7041
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7041
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7041
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7040
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7040
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7039
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7039
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7035
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7035
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7035
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7035
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7034
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7034
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7034
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7034
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7033
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7033
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 2 0.7032
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 2 0.7032
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7031
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7031
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7031
Coniferyl alcohol 9-O-methyltransferase A6XNE6 A6XNE6_9ROSI Linum nodiflorum 2 0.7031
Coniferyl alcohol 9-O-methyltransferase A6XNE6 A6XNE6_9ROSI Linum nodiflorum 2 0.7031
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7031
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7029
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7029
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7028
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7028
Repressor protein Q7X0D9 Q7X0D9_ACIAD Acinetobacter baylyi 2 0.7026
Repressor protein Q7X0D9 Q7X0D9_ACIAD Acinetobacter baylyi 2 0.7026
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7025
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7025
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7025
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7025
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7025
Kallikrein-4 Q9Y5K2 KLK4_HUMAN Homo sapiens 2 0.7025
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7025
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7025
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7023
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7023
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7022
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7022
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7015
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7015
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7013
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7013
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7013
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7013
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7008
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7008
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7006
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7006
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 2 0.7005
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 2 0.7005
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7004
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7004
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 2 0.7004
Polymerase acidic protein Q5EP34 Q5EP34_9INFA Influenza A virus 2 0.7004
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7004
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7004

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