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3alpha,5alpha-dihydroxycostic acid
- Family: Plantae - Asteraceae
- Kingdom: Plantae
-
Class: Terpenoid
- Subclass: Sesquiterpene
| Canonical Smiles | OC(=O)C(=C)[C@@H]1CC[C@@]2([C@@](C1)(O)C(=C)CCC2)C |
|---|---|
| InChI | InChI=1S/C15H22O3/c1-10-5-4-7-14(3)8-6-12(9-15(10,14)18)11(2)13(16)17/h12,18H,1-2,4-9H2,3H3,(H,16,17)/t12-,14-,15+/m1/s1 |
| InChIKey | UEQIFFFWXPAQCB-YUELXQCFSA-N |
| Formula | C15H22O3 |
| HBA | 2 |
| HBD | 2 |
| MW | 250.34 |
| Rotatable Bonds | 2 |
| TPSA | 57.53 |
| LogP | 2.9 |
| Number Rings | 2 |
| Number Aromatic Rings | 0 |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Fraction CSP3 | 0.67 |
| Exact Mass | 250.16 |
| Number of Lipinski Rule Violations | 0 |
| # | Species | Family | Kingdom | NCBI Taxonomy ID |
|---|---|---|---|---|
| 1 | Jasonia montana | Asteraceae | Plantae | 441235 |
| 2 | Pluchea dioscoridis | Asteraceae | Plantae | — |
| 3 | Tarchonanthus camphoratus | Asteraceae | Plantae | 41650 |
Showing of synonyms
3alpha,5alpha-dihydroxycostic acid
5beta-Hydroxycostic acid
132185-84-3
2-[(2R,4aR,8aS)-8a-hydroxy-4a-methyl-8-methylidene-2,3,4,5,6,7-hexahydro-1H-naphthalen-2-yl]prop-2-enoic acid
5-Hydroxycostic acid
5beta-Hydroxtcostic acid
5| cent-hydroxycostic acid
5I(2)-Hydroxycostic acid
DTXSID401314654
132185-83-2
AKOS032948135
FS-10299
CS-0023100
2-(8a-Hydroxy-4a-methyl-8-methylene-decahydro-naphthalen-2-yl)-acrylic acid
Rel-2-[(2R,4aR,8aS)-8a-hydroxy-4a-methyl-8-methylenedecahydronaphthalen-2-yl]acrylic acid
(2R,4aR,8aS)-Decahydro-8a-hydroxy-4a-methyl-alpha,8-bis(methylene)-2-naphthaleneacetic acid
2-[(2R,4AR,8AS)-8A-HYDROXY-4A-METHYL-8-METHYLIDENE-HEXAHYDRO-1H-NAPHTHALEN-2-YL]PROP-2-ENOIC ACID
2-Naphthaleneacetic acid, decahydro-8a-hydroxy-4a-methyl-,8-bis(methylene)-, [2R-(2,4a,8a)]-
(2R,4aR,8aS)-Decahydro-8a-hydroxy-4a-methyl-,8-bis(methylene)-2-naphthaleneacetic acid
2-naphthaleneacetic acid, decahydro-8a-hydroxy-4a-methyl-alpha,8-bis(methylene)-, (2R,4aR,8aS)-
InChI=1/C15H22O3/c1-10-5-4-7-14(3)8-6-12(9-15(10,14)18)11(2)13(16)17/h12,18H,1-2,4-9H2,3H3,(H,16,17)/t12-,14-,15+/m1/s
- Mahmoud AA (1997). 7-Epi-eudesmanes, eudesmanoic acids, eudesmanolides and other sesquiterpenenes from Pluchea dioscoridis. Phytochemistry,1997,45(8),1633-1638. [View]
- Ahmed AA, Jakupovic J (1990). Sesqui- and monoterpenes from Jasonia montana. Phytochemistry,1990,29(11),3658-3661. [View]
- Hegazy MEF, Tawfik WA, et al. (2015). Sesquiterpene acid derivatives from Tarchonanthus camphoratus. Research Journal of Pharmaceutical, Biological and Chemical Sciences,2015,6(1),659-663. [View]
No compound-protein relationship available.
SMILES: C=C1CCCC(C12)CCCC2
Level: 0
Mol. Weight: 250.34 g/mol
No bioactivities available.
Absorption
- Caco-2 (logPapp)
- -4.72
- Human Oral Bioavailability 20%
- Bioavailable
- Human Intestinal Absorption
- Absorbed
- Madin-Darby Canine Kidney
- -4.54
- Human Oral Bioavailability 50%
- Non-Bioavailable
- P-Glycoprotein Inhibitor
- Non-Inhibitor
- P-Glycoprotein Substrate
- Non-Substrate
- Skin Permeability
- -2.06
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Penetrable
- Fraction Unbound (Human)
- 0.46
- Plasma Protein Binding
- 53.7
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Non-Substrate
- CYP 2C19 Inhibitor
- Non-Inhibitor
- CYP 2C19 Substrate
- Non-Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Non-Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Non-Inhibitor
Excretion
- Clearance
- 4.1
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Safe
- Bee
- Toxic
- Bioconcentration Factor
- -0.54
- Biodegradation
- Safe
- Carcinogenesis
- Safe
- Crustacean
- Safe
- Liver Injury I (DILI)
- Safe
- Eye Corrosion
- Safe
- Eye Irritation
- Toxic
- Maximum Tolerated Dose
- 0.17
- Liver Injury II
- Toxic
- hERG Blockers
- Safe
- Daphnia Maga
- 3.39
- Micronucleos
- Safe
- NR-AhR
- Safe
- NR-AR
- Safe
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- 0.03
- Rat (Acute)
- 2.38
- Rat (Chronic Oral)
- 2.22
- Fathead Minnow
- 3.92
- Respiratory Disease
- Safe
- Skin Sensitisation
- Toxic
- SR-ARE
- Safe
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 326.05
- Hydration Free Energy
- -7.66
- Log(D) at pH=7.4
- 0.16
- Log(P)
- 2.94
- Log S
- -2.85
- Log(Vapor Pressure)
- -6.04
- Melting Point
- 135.19
- pKa Acid
- 3.96
- pKa Basic
- 9.23
| Protein Name | UniProt ID | Entry Name | Species | #Pharmacophore Points | Probability (0.7 ≤ Tversky Score ≤ 1.0) |
|---|---|---|---|---|---|
| Pentaerythritol tetranitrate reductase | P71278 | P71278_ENTCL | Enterobacter cloacae | 3 | 0.9515 |
| Pentaerythritol tetranitrate reductase | P71278 | P71278_ENTCL | Enterobacter cloacae | 3 | 0.9515 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9386 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.9386 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.9364 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.9364 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9359 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9359 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9335 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9335 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9316 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.9316 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.9309 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.9309 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.9264 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.9264 |
| Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 3 | 0.9088 |
| Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 3 | 0.9088 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8974 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8974 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.8962 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.8962 |
| Aromatase | P11511 | CP19A_HUMAN | Homo sapiens | 3 | 0.8925 |
| Aromatase | P11511 | CP19A_HUMAN | Homo sapiens | 3 | 0.8925 |
| Prostaglandin reductase 2 | Q8N8N7 | PTGR2_HUMAN | Homo sapiens | 3 | 0.8739 |
| Prostaglandin reductase 2 | Q8N8N7 | PTGR2_HUMAN | Homo sapiens | 3 | 0.8739 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8685 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.8685 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.8602 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.8602 |
| Ferrochelatase, mitochondrial | P22830 | HEMH_HUMAN | Homo sapiens | 3 | 0.8596 |
| Ferrochelatase, mitochondrial | P22830 | HEMH_HUMAN | Homo sapiens | 3 | 0.8596 |
| Retinoic acid receptor RXR-alpha | P19793 | RXRA_HUMAN | Homo sapiens | 3 | 0.8543 |
| Retinoic acid receptor RXR-alpha | P19793 | RXRA_HUMAN | Homo sapiens | 3 | 0.8543 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 3 | 0.8439 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 3 | 0.8439 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8429 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8429 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.8337 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 3 | 0.8337 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8283 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.8283 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8251 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.8251 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 3 | 0.8226 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 3 | 0.8226 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.8034 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.8034 |
| Phospholipase A2 | P00593 | PA21B_BOVIN | Bos taurus | 3 | 0.8001 |
| Phospholipase A2 | P00593 | PA21B_BOVIN | Bos taurus | 3 | 0.8001 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.7963 |
| CmeR | Q7B8P6 | Q7B8P6_CAMJU | Campylobacter jejuni | 3 | 0.7963 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7943 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7943 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.7921 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.7921 |
| NPC intracellular cholesterol transporter 1 | O15118 | NPC1_HUMAN | Homo sapiens | 3 | 0.7910 |
| NPC intracellular cholesterol transporter 1 | O15118 | NPC1_HUMAN | Homo sapiens | 3 | 0.7910 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.7883 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.7883 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7852 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7852 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7835 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7835 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7803 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7803 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7778 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7778 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7776 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7776 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7776 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7776 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7773 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7773 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7758 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7758 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7758 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7758 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7753 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7753 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7748 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7748 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7735 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7735 |
| Corticosteroid-binding globulin | P08185 | CBG_HUMAN | Homo sapiens | 3 | 0.7725 |
| Corticosteroid-binding globulin | P08185 | CBG_HUMAN | Homo sapiens | 3 | 0.7725 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7716 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7716 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7699 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7699 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7687 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7687 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7685 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7685 |
| Abscisic acid receptor PYL3 | Q9SSM7 | PYL3_ARATH | Arabidopsis thaliana | 3 | 0.7678 |
| Abscisic acid receptor PYL3 | Q9SSM7 | PYL3_ARATH | Arabidopsis thaliana | 3 | 0.7678 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.7664 |
| Progesterone receptor | P06401 | PRGR_HUMAN | Homo sapiens | 3 | 0.7664 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7651 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7651 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7651 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7651 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7628 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7628 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7623 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7623 |
| ADP-ribosylation factor 1 | P84080 | ARF1_BOVIN | Bos taurus | 3 | 0.7611 |
| ADP-ribosylation factor 1 | P84080 | ARF1_BOVIN | Bos taurus | 3 | 0.7611 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7595 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7595 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7589 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7589 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7576 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7576 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7564 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7564 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7559 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7559 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7558 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7558 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7552 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7552 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7543 |
| Androgen receptor | O97775 | ANDR_PANTR | Pan troglodytes | 3 | 0.7543 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7540 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7540 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7535 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7535 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7528 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7528 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.7523 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.7523 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7520 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7520 |
| Androgen receptor | P19091 | ANDR_MOUSE | Mus musculus | 3 | 0.7513 |
| Androgen receptor | P19091 | ANDR_MOUSE | Mus musculus | 3 | 0.7513 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7501 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7501 |
| Glucocorticoid receptor | P04150 | GCR_HUMAN | Homo sapiens | 3 | 0.7500 |
| Glucocorticoid receptor | P04150 | GCR_HUMAN | Homo sapiens | 3 | 0.7500 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7492 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7492 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7487 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 3 | 0.7487 |
| ADP-ribosylation factor 1 | P84077 | ARF1_HUMAN | Homo sapiens | 2 | 0.7465 |
| ADP-ribosylation factor 1 | P84077 | ARF1_HUMAN | Homo sapiens | 2 | 0.7465 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7463 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7463 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7431 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7431 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7400 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7400 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7400 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7400 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.7398 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.7398 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7398 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7398 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7368 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7368 |
| Nuclear receptor subfamily 1 group I member 3 | O35627 | NR1I3_MOUSE | Mus musculus | 2 | 0.7362 |
| Nuclear receptor subfamily 1 group I member 3 | O35627 | NR1I3_MOUSE | Mus musculus | 2 | 0.7362 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7356 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7356 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7347 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7347 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7337 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7337 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.7310 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.7310 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 2 | 0.7301 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 2 | 0.7301 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7284 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7284 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.7258 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 3 | 0.7258 |
| Retinol dehydratase | Q26490 | Q26490_SPOFR | Spodoptera frugiperda | 3 | 0.7236 |
| Retinol dehydratase | Q26490 | Q26490_SPOFR | Spodoptera frugiperda | 3 | 0.7236 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7170 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7170 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7142 |
| Androgen receptor | P10275 | ANDR_HUMAN | Homo sapiens | 3 | 0.7142 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.7123 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 3 | 0.7123 |
| Nuclear receptor coactivator 2 | Q15596 | NCOA2_HUMAN | Homo sapiens | 3 | 0.7072 |
| Nuclear receptor coactivator 2 | Q15596 | NCOA2_HUMAN | Homo sapiens | 3 | 0.7072 |
| Aldo-keto reductase family 1 member C1 | Q04828 | AK1C1_HUMAN | Homo sapiens | 2 | 0.7063 |
| Aldo-keto reductase family 1 member C1 | Q04828 | AK1C1_HUMAN | Homo sapiens | 2 | 0.7063 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 2 | 0.7057 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 2 | 0.7057 |
| Fatty acid-binding protein 10-A, liver basic | Q9I8L5 | FA10A_DANRE | Danio rerio | 3 | 0.7025 |
| Fatty acid-binding protein 10-A, liver basic | Q9I8L5 | FA10A_DANRE | Danio rerio | 3 | 0.7025 |
| Glucocorticoid receptor | P04150 | GCR_HUMAN | Homo sapiens | 3 | 0.7017 |
| Glucocorticoid receptor | P04150 | GCR_HUMAN | Homo sapiens | 3 | 0.7017 |