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3beta,14-dihydroxycostunolide-3-O- beta-glucopyranosyl-14-O-p-hydroxyphenylacetate

Family: Plantae - Asteraceae
Kingdom: Plantae
Class: Terpenoid
- Subclass: Sesquiterpene Lactone

Canonical Smiles	OC[C@H]1O[C@@H](O[C@H]2C/C=C(/CCC3[C@@H](/C=C/2\C)OC(=O)C3=C)\COC(=O)Cc2ccc(cc2)O)[C@@H]([C@H]([C@@H]1O)O)O
InChI	InChI=1S/C29H36O11/c1-15-11-22-20(16(2)28(36)38-22)9-5-18(14-37-24(32)12-17-3-7-19(31)8-4-17)6-10-21(15)39-29-27(35)26(34)25(33)23(13-30)40-29/h3-4,6-8,11,20-23,25-27,29-31,33-35H,2,5,9-10,12-14H2,1H3/b15-11+,18-6-/t20?,21-,22+,23+,25+,26-,27+,29+/m0/s1
InChIKey	XASINTHDSBCCBZ-LHBOABJVSA-N
Formula	C₂₉H₃₆O₁₁
HBA	11
HBD	5
MW	560.6
Rotatable Bonds	7
TPSA	172.21
LogP	0.82
Number Rings	4
Number Aromatic Rings	1
Heavy Atom Count	40
Formal Charge	0
Fraction CSP3	0.52
Exact Mass	560.23
Number of Lipinski Rule Violations	2

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Launaea arborescens	Asteraceae	Plantae	43199

Showing of synonyms

Bitam F, Ciavatta ML, et al. (2008). Chemical characterisation of the terpenoid constituents of the Algerian plant Launaea arborescens. Phytochemistry,2008,69,2984-2992. [View] [PubMed]

Pubchem: 163065849

No compound-protein relationship available.

SMILES: c1ccccc1CC(=O)OCC(CC2)=CCC(OC3CCCCO3)C=CC(C24)OC(=O)C4=C

Level: 2

Mol. Weight: 560.6 g/mol

SMILES: c1ccccc1CC(=O)OCC(CC2)=CCCC=CC(C23)OC(=O)C3=C

Level: 1

Mol. Weight: 560.6 g/mol

SMILES: C=C1C(=O)OC(C12)C=CC(CC=CCC2)OC3CCCCO3

Level: 1

Mol. Weight: 560.6 g/mol

SMILES: C=C1C(=O)OC(C12)C=CCCC=CCC2

Level: 0

Mol. Weight: 560.6 g/mol

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 560.6 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 560.6 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -6.13
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.890
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: 0.63

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.900
Plasma Protein Binding: 77.98
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 7.840
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: -2.710
Biodegradation: Toxic
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.390
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.690
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -3583.600
Rat (Acute): 3.200
Rat (Chronic Oral): 3.780
Fathead Minnow: 11.690
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Toxic

General Properties

Boiling Point: 459.980
Hydration Free Energy: -2.920
Log(D) at pH=7.4: 2.090
Log(P): 0.69
Log S: -3.2
Log(Vapor Pressure): -10.97
Melting Point: 170.06
pKa Acid: 6.21
pKa Basic: 4.94

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.9331
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	3	0.9331
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9094
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9094
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9071
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9071
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.9039
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.9039
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9027
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9027
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.9008
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.9008
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.8931
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.8931
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8896
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8896
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.8811
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.8811
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8744
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8744
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8702
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8702
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8679
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8679
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8607
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8607
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8602
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8602
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8577
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8577
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8523
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8523
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.8488
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.8488
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8458
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8458
S-norcoclaurine synthase	Q67A25	NCS_THLFG	Thalictrum flavum subsp. glaucum	3	0.8386
S-norcoclaurine synthase	Q67A25	NCS_THLFG	Thalictrum flavum subsp. glaucum	3	0.8386
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8367
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8367
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8290
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8290
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8192
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8192
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	3	0.8132
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	3	0.8132
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8124
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8124
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7916
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7916
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7914
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7914
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7914
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7914
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7867
beta-glucosidase	Q92AS9	Q92AS9_LISIN	Listeria innocua serovar 6a	3	0.7867
beta-glucosidase	Q92AS9	Q92AS9_LISIN	Listeria innocua serovar 6a	3	0.7867
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7867
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7801
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7801
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.7679
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.7679
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7645
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7645
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	3	0.7614
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	3	0.7614
Pili retraction protein PilT	Q5SHF6	Q5SHF6_THET8	Thermus thermophilus	4	0.7611
Pili retraction protein PilT	Q5SHF6	Q5SHF6_THET8	Thermus thermophilus	4	0.7611
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7607
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7607
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7598
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7598
Quorum-sensing transcriptional activator	Q8XBD0	Q8XBD0_ECO57	Escherichia coli O157:H7	3	0.7579
Quorum-sensing transcriptional activator	Q8XBD0	Q8XBD0_ECO57	Escherichia coli O157:H7	3	0.7579
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7566
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7566
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7520
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7520
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7512
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7512
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7492
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7492
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.7463
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.7463
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7416
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7416
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7403
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7403
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7393
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7393
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7387
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7387
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	3	0.7385
Prenyltransferase	Q4R2T2	Q4R2T2_STRC1	Streptomyces sp	3	0.7385
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7382
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7382
Ribosome-inactivating protein alpha-trichosanthin	P09989	RIPT_TRIKI	Trichosanthes kirilowii	3	0.7355
Ribosome-inactivating protein alpha-trichosanthin	P09989	RIPT_TRIKI	Trichosanthes kirilowii	3	0.7355
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7342
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7342
Oxygenase	Q194P4	Q194P4_STRAA	Streptomyces argillaceus	3	0.7333
Oxygenase	Q194P4	Q194P4_STRAA	Streptomyces argillaceus	3	0.7333
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7325
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7325
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7325
Elongation factor Tu 1	P0CE47	EFTU1_ECOLI	Escherichia coli	3	0.7325
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7311
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7311
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7308
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7308
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7303
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7303
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7301
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7301
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7295
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7295
Genome polyprotein	A9LIE0	A9LIE0_9FLAV	dengue virus type 3	3	0.7286
Genome polyprotein	A9LIE0	A9LIE0_9FLAV	dengue virus type 3	3	0.7286
Beta-galactoside alpha-2,6-sialyltransferase 1	P15907	SIAT1_HUMAN	Homo sapiens	3	0.7257
Beta-galactoside alpha-2,6-sialyltransferase 1	P15907	SIAT1_HUMAN	Homo sapiens	3	0.7257
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7242
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7242
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7231
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7231
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7230
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7230
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7229
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7229
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7219
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7219
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7214
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7214
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7210
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7210
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	2	0.7194
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	2	0.7194
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7187
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7187
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7182
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7182
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7178
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7178
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7171
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7171
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7167
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7167
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7162
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7162
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7149
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7149
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7147
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7147
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7145
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7145
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7145
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7145
Phosphoenolpyruvate carboxykinase [GTP]	P9WIH3	PCKG_MYCTU	Mycobacterium tuberculosis	3	0.7138
Phosphoenolpyruvate carboxykinase [GTP]	P9WIH3	PCKG_MYCTU	Mycobacterium tuberculosis	3	0.7138
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.7135
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.7135
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7135
Purine nucleoside phosphorylase DeoD-type	B1JL34	DEOD_YERPY	Yersinia pseudotuberculosis serotype O:3	2	0.7135
Acyl-CoA:acyl-CoA alkyltransferase	Q8PDX2	OLEA_XANCP	Xanthomonas campestris pv. campestris	3	0.7133
Acyl-CoA:acyl-CoA alkyltransferase	Q8PDX2	OLEA_XANCP	Xanthomonas campestris pv. campestris	3	0.7133
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7132
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7132
Malate dehydrogenase	P10584	MDH_THETH	Thermus thermophilus	3	0.7131
Malate dehydrogenase	P10584	MDH_THETH	Thermus thermophilus	3	0.7131
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7113
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7113
Myosin heavy chain, striated muscle	P24733	MYS_ARGIR	Argopecten irradians	3	0.7107
Myosin heavy chain, striated muscle	P24733	MYS_ARGIR	Argopecten irradians	3	0.7107
Aspartate carbamoyltransferase catalytic subunit	P0A786	PYRB_ECOLI	Escherichia coli	2	0.7091
Aspartate carbamoyltransferase catalytic subunit	P0A786	PYRB_ECOLI	Escherichia coli	2	0.7091
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7088
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7088
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7084
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7084
Holliday junction branch migration complex subunit RuvB	Q9PMT7	RUVB_CAMJE	Campylobacter jejuni subsp. jejuni serotype O:2	2	0.7082
Holliday junction branch migration complex subunit RuvB	Q9PMT7	RUVB_CAMJE	Campylobacter jejuni subsp. jejuni serotype O:2	2	0.7082
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7078
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7078
Phosphoenolpyruvate carboxykinase [GTP]	A5TYT6	PCKG_MYCTA	Mycobacterium tuberculosis	3	0.7068
Phosphoenolpyruvate carboxykinase [GTP]	A5TYT6	PCKG_MYCTA	Mycobacterium tuberculosis	3	0.7068
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7065
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7065
Petrobactin biosynthesis protein AsbB	Q81RQ8	Q81RQ8_BACAN	Bacillus anthracis	3	0.7061
Petrobactin biosynthesis protein AsbB	Q81RQ8	Q81RQ8_BACAN	Bacillus anthracis	3	0.7061
Formylmethanofuran--tetrahydromethanopterin formyltransferase	Q49610	FTR_METKA	Methanopyrus kandleri	3	0.7059
Formylmethanofuran--tetrahydromethanopterin formyltransferase	Q49610	FTR_METKA	Methanopyrus kandleri	3	0.7059
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7057
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7057
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7056
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7056
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7053
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7053
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7049
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7049
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7047
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7047
Cytosolic heat shock protein 90	Q7XJ80	Q7XJ80_HORVU	Hordeum vulgare	3	0.7046
Cytosolic heat shock protein 90	Q7XJ80	Q7XJ80_HORVU	Hordeum vulgare	3	0.7046
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7045
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7045
14-3-3 protein gamma	P61981	1433G_HUMAN	Homo sapiens	3	0.7040
14-3-3 protein gamma	P61981	1433G_HUMAN	Homo sapiens	3	0.7040
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7039
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7039
NAD(P) transhydrogenase subunit alpha part 1	Q2RSB2	PNTAA_RHORT	Rhodospirillum rubrum	3	0.7036
NAD(P) transhydrogenase subunit alpha part 1	Q2RSB2	PNTAA_RHORT	Rhodospirillum rubrum	3	0.7036
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7035
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7035
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7034
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7034
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7027
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7027
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	2	0.7024
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	2	0.7024
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7023
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7023
Mevalonate kinase	P17256	KIME_RAT	Rattus norvegicus	3	0.7021
Mevalonate kinase	P17256	KIME_RAT	Rattus norvegicus	3	0.7021
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7013
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7013
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7012
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7012
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7009
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7009
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7005
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7005
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7004
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7004
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7004
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7004
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7002
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7002
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7002
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7002

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