Onopordin - Compound Card

Onopordin

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Onopordin

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles COc1c(O)cc(c2c1oc(cc2=O)c1ccc(c(c1)O)O)O
InChI InChI=1S/C16H12O7/c1-22-15-12(21)5-10(19)14-11(20)6-13(23-16(14)15)7-2-3-8(17)9(18)4-7/h2-6,17-19,21H,1H3
InChIKey FPSMUVCMXQTXND-UHFFFAOYSA-N
Formula C16H12O7
HBA 7
HBD 4
MW 316.26
Rotatable Bonds 2
TPSA 120.36
LogP 2.29
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.06
Exact Mass 316.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Madia anomala Asteraceae Plantae 71817
2 Madia capitata Asteraceae Plantae 576756
3 Madia citrigracilis Asteraceae Plantae 4253
4 Madia dissitiflora Asteraceae Plantae 907201

Showing of synonyms

  • Wollenweber E, Dörr M, et al. (2003). Flavonoids and terpenoids from the resinous exudates of Madia species (Asteraceae, Helenieae). Zeitschrift fur Naturforschung C,2003,58,153-160. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 316.26 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 316.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 316.26 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.54
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.130
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.56

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.120
Plasma Protein Binding
92.72
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.330
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.960
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.200
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.210
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.890
Rat (Acute)
2.460
Rat (Chronic Oral)
3.090
Fathead Minnow
4.260
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
486.130
Hydration Free Energy
-9.500
Log(D) at pH=7.4
2.760
Log(P)
2.63
Log S
-4.9
Log(Vapor Pressure)
-7.74
Melting Point
281.36
pKa Acid
8.64
pKa Basic
5.96
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9760
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9760
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9570
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9570
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9489
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9489
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9395
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9395
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.9181
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.9181
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9139
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9139
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.9099
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.9099
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9049
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9049
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9014
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9014
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9014
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9014
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8991
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8991
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8949
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8949
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8949
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8949
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8945
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8945
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8929
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8929
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8921
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8921
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8901
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8901
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8897
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8897
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8892
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8892
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8885
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8885
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8837
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8837
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8821
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8821
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 6 0.8821
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 6 0.8821
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8814
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8814
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8806
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8806
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8806
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8806
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8805
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8805
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8805
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8805
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8801
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8801
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8798
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8798
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 7 0.8752
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 7 0.8752
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8751
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8751
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8732
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8732
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8720
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8720
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8701
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8701
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8673
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8673
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8664
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8664
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8647
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8647
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8634
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8634
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8632
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8632
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8628
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8628
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8622
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8622
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8615
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8615
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8566
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8566
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8558
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8558
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8555
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.8555
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8552
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8552
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.8548
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.8548
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8543
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8543
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8533
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8533
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8529
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8529
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8523
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8523
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8515
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8515
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8505
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8505
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8502
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8502
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8499
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8499
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8492
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8492
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8490
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8490
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8482
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8482
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8479
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8479
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8476
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8476
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8473
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8473
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8462
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8462
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8460
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8460
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8460
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8460
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8457
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8457
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8444
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8444
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8443
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8443
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8433
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8433
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8418
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8418
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8414
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8414
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8413
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8413
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8398
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8398
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8394
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8394
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8393
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8393
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8384
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8384
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8377
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8377
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8366
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8366
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8361
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8361
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8354
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8354
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8340
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8340
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8332
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8332
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8329
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8329
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8325
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8325
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8307
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8307
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8306
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8306
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8298
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8298
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8290
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8290
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8279
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8279
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8278
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8278
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8273
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8273
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8232
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8232
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8227
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8227
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8223
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8223
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8210
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8210
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.8203
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.8203
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8196
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8196
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8187
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8187
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8183
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8183
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8172
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8172
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8168
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8168
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8157
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8157
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.8147
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.8147
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8138
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8138
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8129
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8129
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8112
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8112
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8111
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8111
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8106
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8106
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8096
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8096
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8095
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8095
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8082
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8082
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8068
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8068
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8067
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8067
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8064
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8064
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8055
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8055
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8024
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8024
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8006
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8006
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8002
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8002
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8001
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8001
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8000
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8000
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7998
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7998
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7981
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7981
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7977
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7977
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7946
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7946
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7932
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7932
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7910
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7910
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7844
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7844
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7836
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7836
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7820
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7820
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7820
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7820
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7817
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7817
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7799
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7799
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7726
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7726
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7707
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7707
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7705
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7705
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7695
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7695
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7695
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7695
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7669
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7669
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7664
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7664
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7654
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7654
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7644
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7644
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7639
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7639
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7638
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7638
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7627
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7627
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7615
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7615
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7615
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7615
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7610
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7610
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7607
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7607
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7605
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7605
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7605
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7605
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7582
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7582
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7573
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7573
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7568
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7568
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7552
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7552
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7541
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7541
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 3 0.7539
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 3 0.7539
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7538
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7538
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7523
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7523
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 5 0.7521
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 5 0.7521
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7517
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7517
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7507
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7507
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7507
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7507
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7506
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7506
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7499
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7499
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7487
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7487
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7469
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7469
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7467
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7467
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7462
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7462
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7446
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7446
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7442
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7442
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7439
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7439
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7422
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7422
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7414
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7414
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7411
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7411
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7405
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7405
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7403
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7403
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7403
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7403
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7402
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7402
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7395
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7395
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7389
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7389
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7388
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7388
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7382
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7382
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7381
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7381
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7377
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7377
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7376
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7376
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7368
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7368
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7363
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7363
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7352
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7352
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7351
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7351
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7342
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7342
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7341
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7341
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7336
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7336
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7315
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7315
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7307
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7307
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7304
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7304
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7300
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7300
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7292
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7292
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7286
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7286
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7277
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7277
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7274
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7274
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7274
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7274
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7273
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7273
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7273
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7273
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7270
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7270
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7268
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7268
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7262
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7262
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7259
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7259
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7259
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7259
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7257
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7257
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7240
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7240
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7233
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7233
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.7229
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.7229
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7224
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7224
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7224
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7224
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7218
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7218
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7217
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7217
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7206
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7206
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7203
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7203
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7203
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7203
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7202
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7202
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7199
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7199
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7195
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7195
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7188
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7188
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7188
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7188
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7182
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7182
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7178
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7178
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7161
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7161
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7158
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7158
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7157
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7157
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7156
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7156
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7146
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7146
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7139
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7139
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7132
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7132
Histone-arginine methyltransferase CARM1 Q4AE70 CARM1_RAT Rattus norvegicus 4 0.7113
Histone-arginine methyltransferase CARM1 Q4AE70 CARM1_RAT Rattus norvegicus 4 0.7113
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7110
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7110
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7110
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7110
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7084
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7084
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7076
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7076
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7073
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7073
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7067
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7067
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7057
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7057
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7057
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7057
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7046
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7046
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7045
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7045
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7044
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7044
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7040
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7040
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7037
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7037
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7035
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7035
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7034
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7034
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7023
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7023
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 5 0.7020
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7020
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7020
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 5 0.7020
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7017
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7017
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7015
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7015
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7013
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7013
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7005
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7005
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7004
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7004
Malate dehydrogenase P10584 MDH_THETH Thermus thermophilus 3 0.7002
Malate dehydrogenase P10584 MDH_THETH Thermus thermophilus 3 0.7002
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7001
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7001

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