Sideritiflavone - Compound Card

Sideritiflavone

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Sideritiflavone

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone Aglycone
Canonical Smiles COc1c(OC)c(OC)c(c2c1oc(cc2=O)c1ccc(c(c1)O)O)O
InChI InChI=1S/C18H16O8/c1-23-16-14(22)13-11(21)7-12(8-4-5-9(19)10(20)6-8)26-15(13)17(24-2)18(16)25-3/h4-7,19-20,22H,1-3H3
InChIKey UWNUJPINKMRKKR-UHFFFAOYSA-N
Formula C18H16O8
HBA 8
HBD 3
MW 360.32
Rotatable Bonds 4
TPSA 118.59
LogP 2.6
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 360.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Madia anomala Asteraceae Plantae 71817
2 Madia citrigracilis Asteraceae Plantae 4253
3 Madia dissitiflora Asteraceae Plantae 907201

Showing of synonyms

  • Wollenweber E, Dörr M, et al. (2003). Flavonoids and terpenoids from the resinous exudates of Madia species (Asteraceae, Helenieae). Zeitschrift fur Naturforschung C,2003,58,153-160. [View] [PubMed]
Pubchem: 155493
Chebi: 175612
Nmrshiftdb2: 60022378
Bindingdb: 50412300
CPRiL: 446810
Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 360.32 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 360.32 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 360.32 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.16
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.020
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.87

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.270
Plasma Protein Binding
84.86
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.850
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.140
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.330
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.820
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.930
Rat (Acute)
2.380
Rat (Chronic Oral)
2.830
Fathead Minnow
4.850
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
483.610
Hydration Free Energy
-8.930
Log(D) at pH=7.4
2.840
Log(P)
2.48
Log S
-5.27
Log(Vapor Pressure)
-7.86
Melting Point
204.48
pKa Acid
8.14
pKa Basic
2.25
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9821
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9821
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9598
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9598
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9446
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9446
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9317
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9317
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9290
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9290
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9211
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9211
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9187
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9187
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.9014
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.9014
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9008
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9008
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8979
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8979
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 4 0.8973
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 4 0.8973
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8964
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8964
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8927
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8927
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8921
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8921
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8912
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8912
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8910
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8910
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8793
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8793
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8783
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8783
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8768
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8768
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8767
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8767
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8743
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8743
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8688
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8688
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8681
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8681
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8646
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8646
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8642
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8642
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8634
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8634
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8628
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8628
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8625
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8625
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8610
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8610
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.8600
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.8600
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8555
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8555
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8542
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8542
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8540
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8540
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8539
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8539
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8536
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8536
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8526
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8526
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8511
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8511
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8510
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8510
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8508
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8508
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8493
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8493
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8487
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8487
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8465
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8465
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8457
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8457
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8438
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8438
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8433
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8433
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8430
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8430
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8413
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8413
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8381
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8381
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8380
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8380
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8376
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8376
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8376
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8376
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8371
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8371
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8370
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8370
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8357
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8357
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8357
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8357
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.8336
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.8336
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8260
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8260
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8260
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8260
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8255
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8255
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8253
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8253
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8246
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8246
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8218
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8218
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8158
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8158
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8151
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8151
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8091
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8091
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8091
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8091
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8089
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8089
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8040
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8040
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8023
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8023
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.8017
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.8017
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8011
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8011
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8006
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8006
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7976
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7976
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7970
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7970
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7940
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7940
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7937
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7937
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.7934
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 4 0.7934
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.7929
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.7929
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7894
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7894
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7890
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7890
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7888
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7888
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7883
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7883
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7883
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7883
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7879
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7879
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7852
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7852
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7850
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7850
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7849
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7849
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7843
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7843
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7807
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7807
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7805
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7805
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7796
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7796
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7795
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7795
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7784
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7784
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7783
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7783
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7767
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7767
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7744
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7744
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7721
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7721
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7696
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7696
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7694
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7694
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7689
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7689
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7686
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7686
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7672
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7672
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7670
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7670
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7651
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7651
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7651
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7651
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7649
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7649
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7645
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7645
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7631
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7631
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7623
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7623
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7619
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7619
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7618
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7618
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7617
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7617
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7614
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7614
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7593
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7593
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7586
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7586
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7583
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7583
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7572
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7572
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7571
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7571
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7566
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7566
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7565
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7565
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7541
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7541
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7535
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7535
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7520
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7520
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7520
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7520
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7518
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7518
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.7503
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.7503
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7502
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7502
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7500
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7500
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7489
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7489
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7488
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7488
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7488
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7488
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7467
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7467
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7466
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7466
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7465
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7465
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7465
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7465
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7461
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7461
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7441
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7441
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7434
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7434
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7429
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7429
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7421
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7421
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7420
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7420
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7406
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7406
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7387
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7387
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7384
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7384
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7380
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7380
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7380
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7380
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7371
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7371
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7370
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7370
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7361
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7361
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7352
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7352
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7346
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7346
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7338
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7338
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7336
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7336
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7323
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7323
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7315
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7315
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7315
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7315
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7305
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7305
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7299
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7299
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7289
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7289
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7287
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7287
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7282
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7282
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7281
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7281
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7280
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7280
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7279
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7279
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7276
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7276
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7272
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7272
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7265
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7265
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7264
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7264
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7261
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7261
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7260
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7260
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7254
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7254
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7253
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7253
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7253
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7253
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7234
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7234
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7231
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 4 0.7231
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7231
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 4 0.7231
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7219
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7219
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7204
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7204
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7200
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7200
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7193
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7193
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7193
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7193
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7188
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7188
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7181
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7181
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7177
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7177
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7177
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7177
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7177
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7177
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7162
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7162
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7160
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7160
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7157
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7157
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7154
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7154
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7150
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7150
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7147
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7147
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7140
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7140
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7137
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7137
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7137
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7137
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7123
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7123
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7103
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7103
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7099
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7099
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7074
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7074
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7057
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7057
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.7053
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.7053
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7051
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7051
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7050
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7050
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7049
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7049
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7042
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7042
Malate dehydrogenase P10584 MDH_THETH Thermus thermophilus 3 0.7041
Malate dehydrogenase P10584 MDH_THETH Thermus thermophilus 3 0.7041
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7039
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7039
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7036
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7036
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7036
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7036
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7035
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7035
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7033
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7033
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7032
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7032
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7026
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7026
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7022
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7022
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7019
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7019
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7016
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7016
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7015
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7015
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7003
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7003

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