5,3',4'-trihydroxy-3,6,7,8-tetramethoxyflavone - Compound Card

5,3',4'-trihydroxy-3,6,7,8-tetramethoxyflavone

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5,3',4'-trihydroxy-3,6,7,8-tetramethoxyflavone

Structure
Zoomed Structure
  • Family: Plantae - Lamiaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles COc1c(oc2c(c1=O)c(O)c(c(c2OC)OC)OC)c1ccc(c(c1)O)O
InChI InChI=1S/C19H18O9/c1-24-16-12(22)11-13(23)17(25-2)19(27-4)18(26-3)15(11)28-14(16)8-5-6-9(20)10(21)7-8/h5-7,20-21,23H,1-4H3
InChIKey WQDGAXUSPJAKPY-UHFFFAOYSA-N
Formula C19H18O9
HBA 9
HBD 3
MW 390.34
Rotatable Bonds 5
TPSA 127.82
LogP 2.61
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 28
Formal Charge 0
Fraction CSP3 0.21
Exact Mass 390.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Madia anomala Asteraceae Plantae 71817
2 Madia citrigracilis Asteraceae Plantae 4253
3 Madia dissitiflora Asteraceae Plantae 907201
4 Stachys aegyptiaca Lamiaceae Plantae 1391947

Showing of synonyms

  • El-Ansari M, Abdalla M, et al. (1991). Flavonoid constituents of Stachys aegyptiaca. Phytochemistry, 1991,30(4),1169-1173. [View]
  • Wollenweber E, Dörr M, et al. (2003). Flavonoids and terpenoids from the resinous exudates of Madia species (Asteraceae, Helenieae). Zeitschrift fur Naturforschung C,2003,58,153-160. [View] [PubMed]
Pubchem: 54799
Chebi: 196381
Nmrshiftdb2: 60025203

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 390.34 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 390.34 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 390.34 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.38
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.020
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.8

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.270
Plasma Protein Binding
78.48
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.380
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.170
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.370
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
7.600
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-4.800
Rat (Acute)
2.440
Rat (Chronic Oral)
3.020
Fathead Minnow
5.040
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
491.000
Hydration Free Energy
-8.910
Log(D) at pH=7.4
3.230
Log(P)
2.64
Log S
-5.3
Log(Vapor Pressure)
-7.73
Melting Point
191.48
pKa Acid
7.9
pKa Basic
0.24
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9794
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9794
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9295
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9295
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9243
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9243
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9209
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9209
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9047
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9047
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8956
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8956
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8848
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.8848
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8802
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8802
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8781
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8781
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8731
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8731
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8723
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8723
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8694
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8694
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8694
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8694
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8655
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8655
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8639
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8639
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8598
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8598
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8582
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8582
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8572
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8572
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8561
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8561
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8561
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8561
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8553
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8553
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8548
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8548
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8542
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8542
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8512
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8512
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8490
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8490
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8449
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8449
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8441
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8441
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8393
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8393
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8374
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8374
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8368
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8368
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8359
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8359
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8346
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8346
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8324
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8324
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8310
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8310
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8293
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8293
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8273
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8273
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8256
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8256
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8255
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8255
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8217
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8217
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8203
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8203
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.8199
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.8199
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8181
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8181
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8143
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8143
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8135
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8135
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8128
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8128
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8118
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8118
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8106
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8106
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8101
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8101
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8075
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8075
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8070
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8070
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8064
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8064
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7998
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7998
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7977
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7977
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7977
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7977
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7974
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7974
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7970
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7970
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7963
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7963
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7931
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7931
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7903
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7903
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7893
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7893
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7873
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7873
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7861
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7861
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7842
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7842
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7823
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7823
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7799
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7799
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7784
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7784
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7779
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7779
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7733
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7733
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7728
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7728
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7686
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7686
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 7 0.7674
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 7 0.7674
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7667
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7667
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7667
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7667
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7661
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7661
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7660
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7660
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7622
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7622
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7619
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7619
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7613
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7613
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7602
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7602
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7591
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7591
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7587
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7587
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7575
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7575
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7561
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7561
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7549
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7549
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7538
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7538
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.7532
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.7532
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7525
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7525
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7497
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 5 0.7497
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7492
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7492
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7477
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7477
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7467
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7467
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7465
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7465
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7460
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7460
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7457
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7457
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7454
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7454
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7452
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7452
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7448
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7448
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7444
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7444
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7430
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7430
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7423
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7423
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7390
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7390
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7387
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7387
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7376
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7376
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7363
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7363
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7336
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7336
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7318
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7318
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 4 0.7313
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 4 0.7313
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7296
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7296
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7291
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7291
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7278
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7278
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7278
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7278
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7277
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7277
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7272
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7272
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7261
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7261
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7250
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7250
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7245
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7245
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7244
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7244
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7244
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7244
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7241
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7241
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7236
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7236
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7210
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 5 0.7210
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7208
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7208
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7208
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7208
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7198
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7198
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7177
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7177
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7169
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7169
DNA polymerase theta O75417 DPOLQ_HUMAN Homo sapiens 4 0.7163
DNA polymerase theta O75417 DPOLQ_HUMAN Homo sapiens 4 0.7163
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7159
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7159
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7145
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7145
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7139
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.7139
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7130
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7130
Ribosomal RNA large subunit methyltransferase J P37634 RLMJ_ECOLI Escherichia coli 4 0.7130
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7130
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7129
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7129
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7120
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7120
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7117
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7117
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7110
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 4 0.7110
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7110
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7110
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7105
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7105
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7104
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7104
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7077
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7077
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7054
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7054
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7052
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7052
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7051
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7051
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.7038
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.7038
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7038
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7038
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7037
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7037
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7035
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7035
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7035
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7035
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7024
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7024
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7004
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7004
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7003
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7003
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 4 0.7001
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 4 0.7001

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