Apigenin 7-O-beta-glucoside 2'',3''-diacetate - Compound Card

Apigenin 7-O-beta-glucoside 2'',3''-diacetate

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Apigenin 7-O-beta-glucoside 2'',3''-diacetate

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone Glycoside
Canonical Smiles OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)c2ccc(cc2)O)[C@@H]([C@H]([C@@H]1O)OC(=O)C)OC(=O)C
InChI InChI=1S/C25H24O12/c1-11(27)33-23-22(32)20(10-26)37-25(24(23)34-12(2)28)35-15-7-16(30)21-17(31)9-18(36-19(21)8-15)13-3-5-14(29)6-4-13/h3-9,20,22-26,29-30,32H,10H2,1-2H3/t20-,22-,23+,24-,25-/m1/s1
InChIKey RLRNEHZJFFGOEN-PRDVQWLOSA-N
Formula C25H24O12
HBA 12
HBD 4
MW 516.46
Rotatable Bonds 6
TPSA 182.19
LogP 1.19
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 37
Formal Charge 0
Fraction CSP3 0.32
Exact Mass 516.13
Number of Lipinski Rule Violations 2
# Species Family Kingdom NCBI Taxonomy ID
1 Matricaria chamomilla Asteraceae Plantae 98504

Showing of synonyms

  • Redaelli C, Formentini L, et al. (1982). Apigenin 7-glucoside diacetates in ligulate flowers of Matricaria chamomilla. Phytochemistry,1982,21(7),1828-1830. [View]
Pubchem: 21721973
Nmrshiftdb2: 70082003

No compound-protein relationship available.

Structure

SMILES: c1ccccc1-c(cc2=O)oc(c23)cc(cc3)OC4CCCCO4

Level: 2

Mol. Weight: 516.46 g/mol

Structure

SMILES: O=c1ccoc(c12)cc(cc2)OC3CCCCO3

Level: 1

Mol. Weight: 516.46 g/mol

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 516.46 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 516.46 g/mol

Structure

SMILES: C1CCOCC1

Level: 0

Mol. Weight: 516.46 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 516.46 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-6.48
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.630
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-0.46

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.060
Plasma Protein Binding
80.01
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
11.320
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.640
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.100
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.040
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-686.560
Rat (Acute)
2.490
Rat (Chronic Oral)
3.010
Fathead Minnow
5.450
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
555.410
Hydration Free Energy
-2.980
Log(D) at pH=7.4
1.880
Log(P)
2.1
Log S
-4.13
Log(Vapor Pressure)
-10.86
Melting Point
203.89
pKa Acid
7.49
pKa Basic
1.33
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9589
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9589
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9492
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9492
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9307
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9307
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9243
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9243
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9149
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9149
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.9017
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.9017
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8969
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8969
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8940
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8940
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8935
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8935
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.8884
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.8884
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8880
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8880
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8873
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8873
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8846
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8846
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8845
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8845
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8833
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8833
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8827
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8827
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8816
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8816
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8804
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8804
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8797
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8797
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8769
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8769
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8723
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8723
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8657
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8657
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8536
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8536
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8492
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8492
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8475
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8475
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8471
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8471
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8455
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8455
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8448
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8448
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8437
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8437
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.8420
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.8420
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8308
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8308
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8274
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8274
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8261
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8261
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8257
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8257
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8256
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8256
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8252
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8252
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8245
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8245
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8215
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8215
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8185
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8185
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8158
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8158
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8155
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8155
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8107
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8107
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8090
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8090
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8059
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8059
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8035
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8035
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8020
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8020
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8010
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8010
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7997
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7997
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7974
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7974
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7931
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7931
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7890
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7890
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7890
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7890
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7850
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7850
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7827
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7827
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7813
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7813
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7754
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7754
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7747
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7747
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7734
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7734
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 4 0.7732
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 4 0.7732
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7731
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7731
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7724
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7724
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7720
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7720
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7702
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7702
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7664
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7664
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7646
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7646
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7628
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7628
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7619
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7619
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7584
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 4 0.7584
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7581
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7581
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7567
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7567
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7562
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7562
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7551
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7551
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7546
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7546
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7542
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7542
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.7534
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7534
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.7534
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7534
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7518
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7518
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7500
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7500
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7472
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7472
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7465
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7465
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7447
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7447
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7409
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7409
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7392
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7392
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7381
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7381
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7374
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7374
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7369
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7369
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7350
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7350
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7334
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7334
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7333
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7333
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7320
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7320
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7311
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7311
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7300
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7300
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7299
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7299
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7293
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7293
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7293
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7293
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7292
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7292
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7285
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7285
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7278
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7278
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7277
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7277
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7268
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7268
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7265
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7265
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7257
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7257
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7228
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7228
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7223
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7223
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7222
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7222
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7220
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7220
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7211
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7211
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7208
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7208
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7194
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 4 0.7194
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7179
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7179
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7179
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7179
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7170
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7170
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7165
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7165
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7164
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7164
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7158
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7158
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7142
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7142
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7137
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7137
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7124
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7124
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7116
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7116
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7104
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7104
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7098
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7098
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7094
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7094
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7081
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7081
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7067
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7067
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7066
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7066
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7061
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7061
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7056
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7056
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7049
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7049
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7042
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7042
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7032
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7032
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7030
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7030
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7027
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7027
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 4 0.7025
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 4 0.7025
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7024
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7024
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7013
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7013
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7011
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7011
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7004
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7004

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