2-[penta-1,3-diyn-1-yl]-5-[isovaleryloxy-3-chloro-but-1-yn-1-yl] thiophene - Compound Card

2-[penta-1,3-diyn-1-yl]-5-[isovaleryloxy-3-chloro-but-1-yn-1-yl] thiophene

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2-[penta-1,3-diyn-1-yl]-5-[isovaleryloxy-3-chloro-but-1-yn-1-yl] thiophene

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Thiophene
Canonical Smiles CC#CC#Cc1ccc(s1)C#CC(COC(=O)CC(C)C)Cl
InChI InChI=1S/C18H17ClO2S/c1-4-5-6-7-16-10-11-17(22-16)9-8-15(19)13-21-18(20)12-14(2)3/h10-11,14-15H,12-13H2,1-3H3
InChIKey KDKAMVSQBPIJFR-UHFFFAOYSA-N
Formula C18H17ClO2S
HBA 3
HBD 0
MW 332.85
Rotatable Bonds 4
TPSA 26.3
LogP 3.67
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.39
Exact Mass 332.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Pluchea dioscoridis Asteraceae Plantae —
2 Pluchea dioscoridis Asteraceae Plantae —

Showing of synonyms

  • Bohlmann F, Metwally MA, et al. (1984). Eudesmanolides from Pluchea dioscoridis. Phytochemistry,1984,23(9),1975-1977. [View]
  • Dawidar AA, Metwally M (1985). New alpha-cyclocostunolide and isocostic acid derivatives from Pluchea dioscoridis. Chemical and Pharmaceutical Bulletin,1985,33(11),5068-5070. [View]
Pubchem: 162816868

No compound-protein relationship available.

Structure

SMILES: c1ccsc1

Level: 0

Mol. Weight: 332.85 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.5
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.7
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.98

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.54
Plasma Protein Binding
57.54
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.88
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.44
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.71
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.49
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
7.23
Rat (Acute)
2.38
Rat (Chronic Oral)
1.19
Fathead Minnow
5.19
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
368.91
Hydration Free Energy
-3.79
Log(D) at pH=7.4
5.16
Log(P)
6.4
Log S
-5.61
Log(Vapor Pressure)
-5.32
Melting Point
27.0
pKa Acid
9.35
pKa Basic
1.03
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9530
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9530
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9166
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9166
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8975
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8975
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.8911
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.8911
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8855
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8855
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8817
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8817
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8515
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8515
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.8404
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.8404
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8399
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8399
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8387
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8387
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8278
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8278
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8245
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8245
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.8191
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.8191
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.8134
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.8134
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8116
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8116
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.8080
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.8080
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8067
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8067
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8036
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8036
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7984
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7984
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7974
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7974
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7971
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7971
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7956
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7956
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7949
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7949
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7942
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7942
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7902
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7902
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7894
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7894
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7866
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7866
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7850
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7850
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 2 0.7784
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 2 0.7784
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7748
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7748
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7747
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7747
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7728
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7728
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7717
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7717
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7710
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7710
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7710
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7710
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7685
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7685
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7685
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7685
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7671
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7671
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7664
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7664
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7656
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7656
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7628
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7628
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7626
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7626
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7618
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7618
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7612
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7612
Lanosterol 14-alpha demethylase CYP51 P10614 CP51_YEAST Saccharomyces cerevisiae 3 0.7611
Lanosterol 14-alpha demethylase CYP51 P10614 CP51_YEAST Saccharomyces cerevisiae 3 0.7611
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7602
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7602
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7600
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7600
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7589
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7589
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7585
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7585
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7571
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7571
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7569
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7569
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7568
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7568
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7561
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7561
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7507
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7507
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7496
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7496
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7484
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7484
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7468
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7468
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7461
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7461
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7454
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7454
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7454
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7454
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7453
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7453
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7452
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7452
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7440
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7440
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7423
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7423
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7422
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7422
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7410
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7410
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7407
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7407
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7397
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7397
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7388
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7388
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7387
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7387
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7375
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7375
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.7371
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.7371
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7371
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7371
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7357
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7357
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7357
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7357
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7340
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7340
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7333
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7333
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7324
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7324
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7323
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7323
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7303
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7303
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7300
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7300
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7294
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7294
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7292
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7292
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7289
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7289
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7284
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7284
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7280
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7280
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7279
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7279
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7278
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7278
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7271
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7271
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7262
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7262
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7235
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7235
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7232
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7232
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7227
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7227
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 2 0.7220
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 2 0.7220
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7216
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7216
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7215
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7215
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7213
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7213
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7204
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7204
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7203
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7203
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7198
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7198
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7191
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7191
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7190
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7190
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7187
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7187
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 2 0.7181
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 2 0.7181
Protein UshA P07024 USHA_ECOLI Escherichia coli 2 0.7177
Protein UshA P07024 USHA_ECOLI Escherichia coli 2 0.7177
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7171
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7171
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7168
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7168
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7166
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7166
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 2 0.7155
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 2 0.7155
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 2 0.7152
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 2 0.7152
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7140
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7140
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7140
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7140
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7138
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7138
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7134
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7134
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7131
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7131
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7122
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7122
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 2 0.7119
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 2 0.7119
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7117
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7117
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7114
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7114
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7112
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7112
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7106
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7106
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7102
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7102
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7099
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7099
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7095
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7095
Protein claret segregational P20480 NCD_DROME Drosophila melanogaster 2 0.7094
Protein claret segregational P20480 NCD_DROME Drosophila melanogaster 2 0.7094
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7092
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7092
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 3 0.7091
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 3 0.7091
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7074
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7074
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7073
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7073
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7067
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7067
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7063
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7063
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.7063
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.7063
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7050
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7050
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7050
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7050
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7049
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7049
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7047
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7047
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7040
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7040
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7040
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7040
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7038
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7038
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7037
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7037
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7025
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7025
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7020
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7020
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7015
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7015
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7006
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7006
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7004
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7004
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7002
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7002
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7001
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7001

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