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P-methoxyacetophenone

Family: Plantae - Asteraceae
Kingdom: Plantae
Class: Phenolic

Canonical Smiles	COc1ccc(cc1)C(=O)C
InChI	InChI=1S/C9H10O2/c1-7(10)8-3-5-9(11-2)6-4-8/h3-6H,1-2H3
InChIKey	NTPLXRHDUXRPNE-UHFFFAOYSA-N
Formula	C₉H₁₀O₂
HBA	2
HBD	0
MW	150.18
Rotatable Bonds	2
TPSA	26.3
LogP	1.9
Number Rings	1
Number Aromatic Rings	1
Heavy Atom Count	11
Formal Charge	0
Fraction CSP3	0.22
Exact Mass	150.07
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Pyrethrum santolinoides	Asteraceae	Plantae	2072400

Showing of synonyms

Abdel-Mogib M, Jakupovic J, et al. (1989). Sesquiterpene lactones from Pyrethrum santolinoides. Phytochemistry,1989,28(1),268-271. [View]

Pubchem: 7476

Cas: 100-06-1

Zinc: ZINC000000157405

Chebi: 86567

Nmrshiftdb2: 10024793

Chembl: CHEMBL401912

Comptox: DTXSID2044347

Pdb Ligand: O9F

Bindingdb: 50376209

CPRiL: 202084

SMILES: c1ccccc1

Level: 0

Mol. Weight: 150.18 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.21
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -3.980
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.52

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.480
Plasma Protein Binding: 28.34
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.050
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.830
Biodegradation: Toxic
Carcinogenesis: Toxic
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Toxic
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.640
Liver Injury II: Safe
hERG Blockers: Safe
Daphnia Maga: 3.920
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.840
Rat (Acute): 1.710
Rat (Chronic Oral): 2.150
Fathead Minnow: 3.810
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 250.510
Hydration Free Energy: -5.450
Log(D) at pH=7.4: 1.870
Log(P): 1.81
Log S: -2.02
Log(Vapor Pressure): -1.41
Melting Point: 40.53
pKa Acid: 15.45
pKa Basic: 5.26

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9922
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9922
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9825
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9825
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8814
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8814
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.8397
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.8397
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.8207
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.8207
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7965
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7965
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7955
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7955
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	2	0.7766
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	2	0.7766
Peroxidase C1A	P00433	PER1A_ARMRU	Armoracia rusticana	2	0.7761
Peroxidase C1A	P00433	PER1A_ARMRU	Armoracia rusticana	2	0.7761
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	2	0.7739
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	2	0.7739
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7704
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7704
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7701
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7701
Single-strand selective monofunctional uracil DNA glycosylase	Q9YGN6	SMUG1_XENLA	Xenopus laevis	3	0.7700
Single-strand selective monofunctional uracil DNA glycosylase	Q9YGN6	SMUG1_XENLA	Xenopus laevis	3	0.7700
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7635
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7635
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7630
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7630
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7611
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7611
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7545
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7545
Ceramide transfer protein	Q9Y5P4	CERT_HUMAN	Homo sapiens	2	0.7517
Ceramide transfer protein	Q9Y5P4	CERT_HUMAN	Homo sapiens	2	0.7517
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7516
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7516
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7507
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7507
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7497
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7497
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7492
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7492
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7480
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7480
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7463
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7463
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7461
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7461
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7455
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7455
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7450
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7450
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7449
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7449
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7445
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7445
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	2	0.7444
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	2	0.7444
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7421
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7421
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7421
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7421
Chorismate mutase AroH	P19080	AROH_BACSU	Bacillus subtilis	2	0.7418
Chorismate mutase AroH	P19080	AROH_BACSU	Bacillus subtilis	2	0.7418
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7415
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7415
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7415
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7415
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7396
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7396
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7377
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7377
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7375
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7375
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7372
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7372
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7355
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7355
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7355
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	2	0.7355
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7352
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7352
Metallo-beta-lactamase type 2	P26918	BLAB_AERHY	Aeromonas hydrophila	2	0.7347
Metallo-beta-lactamase type 2	P26918	BLAB_AERHY	Aeromonas hydrophila	2	0.7347
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7346
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7346
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	2	0.7343
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	2	0.7343
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	2	0.7332
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	2	0.7332
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7331
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7331
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	2	0.7330
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	2	0.7330
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7329
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7329
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	2	0.7328
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	2	0.7328
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7326
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7326
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	2	0.7326
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	2	0.7326
RIO-type serine/threonine-protein kinase Rio1	O28471	RIO1_ARCFU	Archaeoglobus fulgidus	2	0.7319
RIO-type serine/threonine-protein kinase Rio1	O28471	RIO1_ARCFU	Archaeoglobus fulgidus	2	0.7319
Catalase-peroxidase	Q3JNW6	KATG_BURP1	Burkholderia pseudomallei	2	0.7317
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	2	0.7317
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	2	0.7317
Catalase-peroxidase	Q3JNW6	KATG_BURP1	Burkholderia pseudomallei	2	0.7317
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	2	0.7314
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7314
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7314
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	2	0.7314
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7305
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7305
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7304
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7304
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	2	0.7301
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	2	0.7301
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7300
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7300
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7298
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7298
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7292
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7292
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	2	0.7292
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	2	0.7292
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7290
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7290
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7284
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7284
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase	P47229	BPHD_PARXL	Paraburkholderia xenovorans	2	0.7280
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase	P47229	BPHD_PARXL	Paraburkholderia xenovorans	2	0.7280
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	2	0.7279
Mitogen-activated protein kinase kinase kinase 5	Q99683	M3K5_HUMAN	Homo sapiens	2	0.7279
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7278
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7278
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7277
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7277
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7271
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7271
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7270
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7270
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7262
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7262
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7260
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7260
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7243
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7243
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7239
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7239
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7237
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7237
Ribosome-inactivating protein 3	P25891	RIP3_MAIZE	Zea mays	2	0.7235
Ribosome-inactivating protein 3	P25891	RIP3_MAIZE	Zea mays	2	0.7235
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7232
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7232
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7231
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7231
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7229
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7229
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7228
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7228
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7226
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7226
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7224
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7224
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7222
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7222
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7219
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7219
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	2	0.7213
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	2	0.7213
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	2	0.7212
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	2	0.7212
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7206
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7206
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7204
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7204
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	2	0.7198
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	2	0.7198
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7196
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7196
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7193
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7193
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7192
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7192
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7188
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7188
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7179
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7179
Aspartate aminotransferase, mitochondrial	P00508	AATM_CHICK	Gallus gallus	2	0.7178
Aspartate aminotransferase, mitochondrial	P00508	AATM_CHICK	Gallus gallus	2	0.7178
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7176
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7176
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7168
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7168
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7156
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7156
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7153
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7153
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	2	0.7153
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	2	0.7153
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7147
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7147
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7144
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7144
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7143
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7143
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7141
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7141
Serine/threonine-protein kinase N1	Q16512	PKN1_HUMAN	Homo sapiens	2	0.7137
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7137
Serine/threonine-protein kinase N1	Q16512	PKN1_HUMAN	Homo sapiens	2	0.7137
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7137
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7136
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7136
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7136
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7136
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7134
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7134
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	2	0.7126
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	2	0.7126
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7123
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7123
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7116
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7116
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7116
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7116
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	2	0.7112
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	2	0.7112
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7104
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7104
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7102
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7102
cAMP-dependent protein kinase catalytic subunit alpha	P05132	KAPCA_MOUSE	Mus musculus	2	0.7099
cAMP-dependent protein kinase catalytic subunit alpha	P05132	KAPCA_MOUSE	Mus musculus	2	0.7099
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	2	0.7096
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7096
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	2	0.7096
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7096
12-oxophytodienoate reductase 1	Q9XG54	OPR1_SOLLC	Solanum lycopersicum	2	0.7092
12-oxophytodienoate reductase 1	Q9XG54	OPR1_SOLLC	Solanum lycopersicum	2	0.7092
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7089
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7089
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7088
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7088
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	2	0.7087
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	2	0.7087
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	2	0.7084
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	2	0.7084
Cell division control protein 42 homolog	P60953	CDC42_HUMAN	Homo sapiens	2	0.7083
Cell division control protein 42 homolog	P60953	CDC42_HUMAN	Homo sapiens	2	0.7083
L-lactate dehydrogenase (cytochrome)	P00175	CYB2_YEAST	Saccharomyces cerevisiae	2	0.7072
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7072
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7072
L-lactate dehydrogenase (cytochrome)	P00175	CYB2_YEAST	Saccharomyces cerevisiae	2	0.7072
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7071
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7071
Alpha/beta hydrolase fold	A5VAT9	A5VAT9_SPHWW	Sphingomonas wittichii	2	0.7066
Alpha/beta hydrolase fold	A5VAT9	A5VAT9_SPHWW	Sphingomonas wittichii	2	0.7066
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7060
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7060
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7055
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7055
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7055
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7055
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7051
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7051
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	2	0.7050
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	2	0.7050
Ferric enterobactin-binding periplasmic protein FepB	P0AEL6	FEPB_ECOLI	Escherichia coli	3	0.7049
Ferric enterobactin-binding periplasmic protein FepB	P0AEL6	FEPB_ECOLI	Escherichia coli	3	0.7049
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7047
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7047
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	2	0.7030
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	2	0.7030
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7028
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7028
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7024
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7024
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7015
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7015
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7013
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7013
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7012
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7012
Nitric oxide synthase 3	P29474	NOS3_HUMAN	Homo sapiens	2	0.7005
Nitric oxide synthase 3	P29474	NOS3_HUMAN	Homo sapiens	2	0.7005
LL-diaminopimelate aminotransferase, chloroplastic	Q93ZN9	DAPAT_ARATH	Arabidopsis thaliana	2	0.7003
LL-diaminopimelate aminotransferase, chloroplastic	Q93ZN9	DAPAT_ARATH	Arabidopsis thaliana	2	0.7003
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7002
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7002
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7001
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7001

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