5-hydroxy-6,7,3',4',5'-pentamethoxyflavone - Compound Card

5-hydroxy-6,7,3',4',5'-pentamethoxyflavone

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5-hydroxy-6,7,3',4',5'-pentamethoxyflavone

Structure
Zoomed Structure
  • Family: Plantae - Combretaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavonoid Aglycone
Canonical Smiles COc1c(OC)cc(cc1OC)c1cc(=O)c2c(o1)cc(c(c2O)OC)OC
InChI InChI=1S/C20H20O8/c1-23-14-6-10(7-15(24-2)19(14)26-4)12-8-11(21)17-13(28-12)9-16(25-3)20(27-5)18(17)22/h6-9,22H,1-5H3
InChIKey QULPQWKDDOBIOC-UHFFFAOYSA-N
Formula C20H20O8
HBA 8
HBD 1
MW 388.37
Rotatable Bonds 6
TPSA 96.59
LogP 3.21
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 28
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 388.12
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Psiadia punctulata Asteraceae Plantae 72969
2 Combretum glutinosum Combretaceae Plantae 578539

Showing of synonyms

  • Toklo PM, Yayi Ladekan E, et al. (2021). Anthelmintic flavonoids and other compounds from Combretum glutinosum Perr. ex DC (Combretaceae) leaves.. Acta crystallographica. Section C, Structural chemistry,2021, 77(Pt 9), 505-512. [View] [PubMed]
  • Abou-Zaid MM, El-Karemy Z, et al. (1991). The flavonoids of Psiadia punctulata. Bulletin of the Chemical Society of Ethiopia,1991,5(1),37-40. [View]
Pubchem: 73648
Nmrshiftdb2: 60020376
CPRiL: 437583
Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 388.37 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 388.37 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 388.37 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.59
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.810
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.63

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.390
Plasma Protein Binding
77.76
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.330
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.980
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.180
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.040
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-6.770
Rat (Acute)
2.540
Rat (Chronic Oral)
2.370
Fathead Minnow
5.340
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
463.940
Hydration Free Energy
-8.120
Log(D) at pH=7.4
3.230
Log(P)
2.88
Log S
-4.58
Log(Vapor Pressure)
-7.73
Melting Point
169.91
pKa Acid
7.78
pKa Basic
2.08
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9778
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9778
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9733
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9733
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9672
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9672
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9652
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9652
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9423
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9423
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9304
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9304
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9300
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9300
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9225
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9225
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9127
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9127
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9127
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9127
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9082
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9082
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9062
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9062
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8968
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8968
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8946
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8946
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8941
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8941
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8905
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8905
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8810
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8810
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8782
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8782
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8778
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8778
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8773
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8773
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8764
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8764
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8755
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8755
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8726
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8726
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8718
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8718
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8679
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8679
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8669
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8669
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8662
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8662
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8646
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8646
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8572
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8572
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8561
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8561
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8561
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8561
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8536
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8536
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8475
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8475
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8425
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8425
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8420
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8420
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8412
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8412
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8410
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8410
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8405
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8405
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.8389
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.8389
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8373
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8373
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8347
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8347
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8328
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8328
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8275
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8275
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8177
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8177
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8176
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8176
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8170
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8170
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8165
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8165
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8135
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8135
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8133
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8133
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8118
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8118
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8052
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8052
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8033
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8011
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8011
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7987
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7987
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7986
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7986
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7970
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7970
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7948
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7948
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7925
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7925
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7912
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7912
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7909
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7909
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7896
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7896
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7888
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7888
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7835
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7835
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7823
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7823
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7813
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7813
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7796
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7796
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7794
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7794
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7776
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7776
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7728
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7728
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7711
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7711
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7665
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7665
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7662
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7662
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7654
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7654
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7654
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7654
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7650
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7650
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7649
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7649
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7620
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7620
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7617
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7617
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7611
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7611
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7602
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7602
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7602
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7602
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7594
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7594
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7593
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7593
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7585
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7585
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7558
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7558
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7553
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7553
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7531
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7531
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7531
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7531
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7527
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7527
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7526
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7526
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7497
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7497
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7479
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7479
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7471
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7471
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7464
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7464
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7434
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7434
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7430
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7430
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic Q9FYS3 HGGL_SECCE Secale cereale 3 0.7422
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7422
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7422
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic Q9FYS3 HGGL_SECCE Secale cereale 3 0.7422
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7417
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7417
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7404
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7404
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7397
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7397
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7396
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7396
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7373
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7373
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7370
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7370
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7361
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7361
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7346
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7346
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7339
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7339
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7334
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7334
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7330
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7330
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7303
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7303
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7291
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7291
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7287
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7287
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7286
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7286
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7286
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7286
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7282
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7282
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7278
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7278
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7260
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7260
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7260
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7260
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7259
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7259
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7256
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7256
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7256
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7256
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7253
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7253
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7252
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7252
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7242
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7242
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7224
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7224
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7220
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7220
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7219
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7219
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7218
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7218
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7217
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7217
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7206
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7206
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7190
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7190
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7143
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7143
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7137
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7137
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7131
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7131
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7129
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7129
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7128
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7128
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7118
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7118
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7114
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7114
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7110
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7110
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7110
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7110
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7099
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7099
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7083
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7083
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7071
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7071
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7066
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7066
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7060
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7060
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7055
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7055
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7053
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7053
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7043
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7043
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7042
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7042
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7035
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7035
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7034
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7034
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7030
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7030
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7027
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7027
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7024
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7024
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7022
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7022
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7016
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7016
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7016
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7016
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7015
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7015
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7012
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7012
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7007
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7007
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7006
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7006

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