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Ancistrocladidine

Family: Plantae - Ancistrocladaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Naphthylisoquinoline Alkaloid

Canonical Smiles	COc1cc2C[C@H](C)N=C(c2c(c1c1c(C)cc2c(c1O)c(OC)ccc2)OC)C
InChI	InChI=1S/C25H27NO4/c1-13-10-16-8-7-9-18(28-4)22(16)24(27)20(13)23-19(29-5)12-17-11-14(2)26-15(3)21(17)25(23)30-6/h7-10,12,14,27H,11H2,1-6H3/t14-/m0/s1
InChIKey	CESMSNGGFQBVOV-AWEZNQCLSA-N
Formula	C₂₅H₂₇NO₄
HBA	5
HBD	1
MW	405.49
Rotatable Bonds	4
TPSA	60.28
LogP	5.3
Number Rings	4
Number Aromatic Rings	3
Heavy Atom Count	30
Formal Charge	0
Fraction CSP3	0.32
Exact Mass	405.19
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Ancistrocladus tanzaniensis	Ancistrocladaceae	Plantae	714107

Showing of synonyms

Bringmann G, Dreyer M, et al. (2004). Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis. Journal of Natural Products,2004,67(5),743-748. [View] [PubMed]

Pubchem: 193880

Cas: 52659-52-6

Zinc: ZINC000013359350

Nmrshiftdb2: 70016258

Chembl: CHEMBL222436

No compound-protein relationship available.

SMILES: c1cccc(c12)ccc(c2)-c(c3)ccc(c34)CCN=C4

Level: 1

Mol. Weight: 405.49 g/mol

SMILES: C1=NCCc(c12)cccc2

Level: 0

Mol. Weight: 405.49 g/mol

SMILES: c1cccc(c12)cccc2

Level: 0

Mol. Weight: 405.49 g/mol

Antiprotozoal

Absorption

Caco-2 (logPapp): -4.84
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.710
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.38

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.490
Plasma Protein Binding: 90.03
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.080
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 2.330
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.900
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.000
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -28.370
Rat (Acute): 2.610
Rat (Chronic Oral): 2.270
Fathead Minnow: 5.410
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Toxic
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 495.920
Hydration Free Energy: -5.230
Log(D) at pH=7.4: 3.450
Log(P): 5.0
Log S: -6.48
Log(Vapor Pressure): -8.24
Melting Point: 147.5
pKa Acid: 9.34
pKa Basic: 8.66

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.9424
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.9424
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.9371
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.9371
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.9260
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.9260
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9129
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9129
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8979
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8979
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8970
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8970
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8960
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8960
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8907
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8907
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8880
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8880
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8697
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8697
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.8524
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.8524
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8406
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8406
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.8332
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.8332
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8328
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8328
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8305
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8305
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8250
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8250
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.8191
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.8191
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8164
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8164
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8092
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8092
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8082
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8082
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8076
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8076
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7980
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7980
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7942
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7942
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7941
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7941
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.7930
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.7930
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7916
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7916
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7909
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7909
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7860
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7860
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	3	0.7835
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	3	0.7835
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7834
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7834
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7766
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7766
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7686
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7686
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7684
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7684
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7658
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7658
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7623
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7623
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7570
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7570
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7570
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7570
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7567
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7567
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7542
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7542
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7540
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7540
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7524
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7524
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7523
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7523
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7503
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7503
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7465
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7465
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7463
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7463
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	4	0.7451
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	4	0.7451
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7435
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7435
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7405
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7405
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7378
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7378
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7377
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7377
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7357
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7357
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7353
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7353
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	4	0.7348
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	4	0.7348
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7336
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7336
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7334
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7334
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.7323
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.7323
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7316
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7316
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7313
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7313
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7311
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7311
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7300
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7300
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7296
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7296
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7266
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7266
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7233
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7233
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7229
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7229
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7210
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7210
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7208
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7208
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7200
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7200
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7179
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7179
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7171
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7171
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7169
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7169
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7161
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7161
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7156
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7156
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7155
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7155
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7151
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7151
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7129
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7129
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7107
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7107
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7094
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7094
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7092
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7092
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7088
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7088
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7077
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7077
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7074
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7074
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7071
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7071
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7064
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7064
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7049
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7049
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.7041
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.7041
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7037
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7037
4-hydroxyphenylacetate 3-monooxygenase, reductase component	Q5SJP7	HPAC_THET8	Thermus thermophilus	3	0.7027
4-hydroxyphenylacetate 3-monooxygenase, reductase component	Q5SJP7	HPAC_THET8	Thermus thermophilus	3	0.7027
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7021
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7021
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7018
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7018
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7014
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7014
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7004
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7004
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7001
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7001

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