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Ancistrotectorine

Family: Plantae - Ancistrocladaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Naphthylisoquinoline Alkaloid

Canonical Smiles	COc1cc2C[C@H](C)N([C@@H](c2c(c1c1c(C)cc2c(c1O)c(OC)ccc2)OC)C)C
InChI	InChI=1S/C26H31NO4/c1-14-11-17-9-8-10-19(29-5)23(17)25(28)21(14)24-20(30-6)13-18-12-15(2)27(4)16(3)22(18)26(24)31-7/h8-11,13,15-16,28H,12H2,1-7H3/t15-,16+/m0/s1
InChIKey	BHQAJMGEYYHIGV-JKSUJKDBSA-N
Formula	C₂₆H₃₁NO₄
HBA	5
HBD	1
MW	421.54
Rotatable Bonds	4
TPSA	51.16
LogP	5.48
Number Rings	4
Number Aromatic Rings	3
Heavy Atom Count	31
Formal Charge	0
Fraction CSP3	0.38
Exact Mass	421.23
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Ancistrocladus tanzaniensis	Ancistrocladaceae	Plantae	714107

Showing of synonyms

Bringmann G, Dreyer M, et al. (2004). Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis. Journal of Natural Products,2004,67(5),743-748. [View] [PubMed]

Pubchem: 179169

Cas: 98985-59-2

Zinc: ZINC000004654687

Kegg Ligand: C12340

Chebi: 31213

Nmrshiftdb2: 70016257

Chembl: CHEMBL463908

Comptox: DTXSID00243899

No compound-protein relationship available.

SMILES: c1cccc(c12)ccc(c2)-c(c3)ccc(c34)CCNC4

Level: 1

Mol. Weight: 421.54 g/mol

SMILES: C1CNCc(c12)cccc2

Level: 0

Mol. Weight: 421.54 g/mol

SMILES: c1cccc(c12)cccc2

Level: 0

Mol. Weight: 421.54 g/mol

Antiprotozoal

Absorption

Caco-2 (logPapp): -4.98
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.770
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -1.12

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.200
Plasma Protein Binding: 79.12
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 9.240
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 3.010
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.600
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 10.020
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -52.970
Rat (Acute): 2.760
Rat (Chronic Oral): 1.980
Fathead Minnow: 5.320
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 461.670
Hydration Free Energy: -4.970
Log(D) at pH=7.4: 3.830
Log(P): 4.66
Log S: -4.45
Log(Vapor Pressure): -8.94
Melting Point: 139.88
pKa Acid: 9.63
pKa Basic: 9.37

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.9441
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.9441
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.9321
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.9321
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.9299
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.9299
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9060
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9060
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8907
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8907
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8810
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8810
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.8731
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.8731
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.8553
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.8553
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8474
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8474
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.8427
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.8427
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.8341
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.8341
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8304
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8304
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8257
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8257
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8210
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8210
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8201
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8201
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8119
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8119
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8107
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8107
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.8106
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.8106
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8088
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8088
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8084
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.8084
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8022
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8022
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7994
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7994
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7983
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7983
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7962
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7962
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7939
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7939
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7936
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7936
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7904
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7904
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7891
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7891
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7887
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7887
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7880
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7880
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	5	0.7878
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7878
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7878
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	5	0.7878
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7874
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7874
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7860
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7860
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	3	0.7800
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	3	0.7800
Acetyl-CoA carboxylase	Q00955	ACAC_YEAST	Saccharomyces cerevisiae	5	0.7750
Acetyl-CoA carboxylase	Q00955	ACAC_YEAST	Saccharomyces cerevisiae	5	0.7750
Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CP17A_HUMAN	Homo sapiens	3	0.7738
Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CP17A_HUMAN	Homo sapiens	3	0.7738
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7722
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7722
Renin	P00797	RENI_HUMAN	Homo sapiens	3	0.7699
Renin	P00797	RENI_HUMAN	Homo sapiens	3	0.7699
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7697
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7697
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7666
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7666
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7662
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7662
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7650
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7650
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7650
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.7650
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7640
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7640
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7627
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7627
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7623
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7623
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7596
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7596
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.7589
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.7589
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7549
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7549
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7549
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7549
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7543
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7543
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7498
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7498
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7493
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7493
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7470
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7470
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7458
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7458
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7446
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7446
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7433
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7433
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7428
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7428
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7409
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7409
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7409
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7409
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	4	0.7400
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	4	0.7400
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	4	0.7386
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	4	0.7386
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7372
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7372
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7366
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7366
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7303
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7303
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7294
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7294
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7293
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7293
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7286
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7286
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7264
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7264
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7247
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7247
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7240
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7240
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7230
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7230
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7229
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7229
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7214
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7214
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7210
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7210
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7202
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7202
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	3	0.7188
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	3	0.7188
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7164
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7164
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.7161
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.7161
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7153
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7153
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7148
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7148
GTP 3',8-cyclase	P69848	MOAA_STAA8	Staphylococcus aureus	3	0.7136
GTP 3',8-cyclase	P69848	MOAA_STAA8	Staphylococcus aureus	3	0.7136
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.7130
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.7130
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7128
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7128
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7122
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.7122
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7119
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7119
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7103
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7103
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7084
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7084
cGMP-dependent protein kinase, putative	A5K0N4	A5K0N4_PLAVS	Plasmodium vivax	3	0.7070
cGMP-dependent protein kinase, putative	A5K0N4	A5K0N4_PLAVS	Plasmodium vivax	3	0.7070
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7057
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7057
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7053
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7053
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7044
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7044
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.7043
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.7043
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7037
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7037
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7035
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7035
Dihydrofolate reductase type 1 from Tn4003	P13955	DYRA_STAAU	Staphylococcus aureus	3	0.7035
Dihydrofolate reductase type 1 from Tn4003	P13955	DYRA_STAAU	Staphylococcus aureus	3	0.7035
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7027
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7027
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7023
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7023
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7020
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7020
Dihydrofolate reductase	P9WNX1	DYR_MYCTU	Mycobacterium tuberculosis	3	0.7019
Dihydrofolate reductase	P9WNX1	DYR_MYCTU	Mycobacterium tuberculosis	3	0.7019
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7005
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7005
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7004
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7004

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