(+)-6-styryl-7,8-dihydroxy-4- methoxypyran-2-one - Compound Card

(+)-6-styryl-7,8-dihydroxy-4- methoxypyran-2-one

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(+)-6-styryl-7,8-dihydroxy-4- methoxypyran-2-one

Structure
Zoomed Structure
  • Family: Annonaceae
  • Kingdom: Plantae
  • Class: Phenanthrenoid
    • Subclass: Pyrone
Canonical Smiles COc1cc(oc(=O)c1)[C@@H]([C@@H](c1ccccc1)O)O
InChI InChI=1S/C14H14O5/c1-18-10-7-11(19-12(15)8-10)14(17)13(16)9-5-3-2-4-6-9/h2-8,13-14,16-17H,1H3/t13-,14+/m1/s1
InChIKey PLPIXLSRTIVHDP-KGLIPLIRSA-N
Formula C14H14O5
HBA 5
HBD 2
MW 262.26
Rotatable Bonds 4
TPSA 79.9
LogP 1.42
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.21
Exact Mass 262.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Ophrypetalum odoratum Annonaceae Plantae 489344
2 Sanrafaelia ruffonammari Annonaceae Plantae 489346

Showing of synonyms

  • Malebo HM, Kihampa C, et al. (2014). Antifungal enantiomeric styrylpyrones from Sanrafaelia ruffonammari and Ophrypetalum odoratum. Natural Products and Bioprospecting,2014,4(2),129-133. [View] [PubMed]
Pubchem: 163031853
Nmrshiftdb2: 70070888

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CCc2cccc(=O)o2

Level: 1

Mol. Weight: 200.24 g/mol

Structure

SMILES: O=c1cccco1

Level: 0

Mol. Weight: 96.08 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

Antifungal

Absorption

Caco-2 (logPapp)
-4.89
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-3.780
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.69

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.780
Plasma Protein Binding
70.19
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.910
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.030
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.650
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
3.850
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.940
Rat (Acute)
2.020
Rat (Chronic Oral)
2.040
Fathead Minnow
4.040
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
361.770
Hydration Free Energy
-11.580
Log(D) at pH=7.4
0.770
Log(P)
0.75
Log S
-2.02
Log(Vapor Pressure)
-7.06
Melting Point
120.94
pKa Acid
7.89
pKa Basic
1.01
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9815
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9815
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9523
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9523
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.9498
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.9498
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.9420
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.9420
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9385
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9385
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.9377
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.9377
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9356
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9356
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9335
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9335
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.9320
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.9320
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9272
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9272
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9190
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9190
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9171
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9171
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9161
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9161
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9067
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9067
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9042
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9042
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9041
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9041
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9001
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9001
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9000
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9000
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8998
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8998
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8991
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8991
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8842
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8842
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8838
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8838
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8833
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8833
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8818
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8818
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8797
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8797
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8797
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8797
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.8779
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.8779
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8767
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8767
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8764
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8764
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8760
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8760
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.8748
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.8748
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8743
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8743
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8708
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8708
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.8700
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.8700
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8642
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8642
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8635
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8635
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8630
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8630
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8602
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8602
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8578
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8578
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8525
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8525
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8502
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8502
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8498
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8498
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8480
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8480
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8479
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8479
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8463
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8463
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8448
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8448
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8408
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8408
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.8407
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.8407
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8401
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8401
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8393
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8393
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 4 0.8376
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 4 0.8376
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8361
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8361
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8356
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8356
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8307
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8307
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8307
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8307
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8295
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8295
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8291
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8291
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8265
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8265
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8251
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8251
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8248
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8248
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8213
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8213
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8211
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8211
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8197
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8197
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8173
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8173
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8138
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8138
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8137
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8137
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8126
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8126
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8114
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8114
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.8093
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.8093
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8092
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8092
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8072
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8072
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8048
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8048
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8047
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8047
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.8037
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.8037
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.8015
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.8015
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7996
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7996
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7991
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7991
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7928
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7928
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7922
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7922
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7898
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7898
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 3 0.7890
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 3 0.7890
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7885
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7885
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 3 0.7859
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 3 0.7859
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7840
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7840
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7822
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7822
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7791
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7791
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.7785
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.7785
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7777
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7777
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7764
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7764
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7748
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7748
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7743
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7743
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7742
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7742
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7730
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7730
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7730
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7730
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7729
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7729
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7729
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7729
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7728
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7728
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7719
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7719
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7693
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7693
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7688
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7688
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7684
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7684
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7676
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7676
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7672
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7672
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7669
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7669
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7666
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7666
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7652
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7652
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7646
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7646
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7623
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7623
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7617
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7617
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7610
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7610
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7607
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7607
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7599
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7599
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7586
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7586
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7554
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7554
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7540
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7540
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7535
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7535
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7534
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7534
Pyruvate decarboxylase isozyme 1 P06169 PDC1_YEAST Saccharomyces cerevisiae 3 0.7528
Pyruvate decarboxylase isozyme 1 P06169 PDC1_YEAST Saccharomyces cerevisiae 3 0.7528
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7527
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7527
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7519
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7519
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7512
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7512
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7507
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7507
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7505
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7505
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7504
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7504
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7501
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7501
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7501
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7501
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7496
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7496
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7484
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7484
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7482
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7482
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7452
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7452
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7448
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7448
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7447
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7447
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7421
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7421
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7417
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7417
Pyruvate oxidase P37063 POXB_LACPL Lactiplantibacillus plantarum 3 0.7414
Pyruvate oxidase P37063 POXB_LACPL Lactiplantibacillus plantarum 3 0.7414
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7411
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7411
Muscarinic acetylcholine receptor M3 P08483 ACM3_RAT Rattus norvegicus 4 0.7401
Muscarinic acetylcholine receptor M3 P08483 ACM3_RAT Rattus norvegicus 4 0.7401
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7380
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7380
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7379
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7379
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7363
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7363
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7363
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7363
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7336
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7336
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7335
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7335
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7334
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7334
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7327
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7327
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7327
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7327
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7322
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7322
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7319
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7319
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7309
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7309
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7303
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7303
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7302
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7302
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7301
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7301
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 4 0.7282
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 4 0.7282
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7281
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7281
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 3 0.7281
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 3 0.7281
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7275
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7275
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7274
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7274
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7269
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7269
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7268
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7268
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7264
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7264
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7264
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7264
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7264
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7264
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7263
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7263
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7257
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7257
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7253
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7253
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7244
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7244
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7241
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7241
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7237
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7237
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7236
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7236
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7235
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7235
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7234
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7234
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7234
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7234
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7229
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7229
Indole-3-pyruvate decarboxylase P23234 DCIP_ENTCL Enterobacter cloacae 3 0.7227
Indole-3-pyruvate decarboxylase P23234 DCIP_ENTCL Enterobacter cloacae 3 0.7227
Pyruvate dehydrogenase E1 component P0AFG8 ODP1_ECOLI Escherichia coli 3 0.7226
Pyruvate dehydrogenase E1 component P0AFG8 ODP1_ECOLI Escherichia coli 3 0.7226
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7219
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7219
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7217
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7217
Multifunctional 2-oxoglutarate metabolism enzyme A0R2B1 KGD_MYCS2 Mycolicibacterium smegmatis155) 3 0.7216
Multifunctional 2-oxoglutarate metabolism enzyme A0R2B1 KGD_MYCS2 Mycolicibacterium smegmatis155) 3 0.7216
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7213
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7213
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase P9WK11 MEND_MYCTU Mycobacterium tuberculosis 3 0.7209
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase P9WK11 MEND_MYCTU Mycobacterium tuberculosis 3 0.7209
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7203
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7203
Thymidylate kinase Q9KQI2 KTHY_VIBCH Vibrio cholerae serotype O1 3 0.7198
Thymidylate kinase Q9KQI2 KTHY_VIBCH Vibrio cholerae serotype O1 3 0.7198
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7196
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7196
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7195
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7195
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7191
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7191
transketolase Q2SZA7 Q2SZA7_BURTA Burkholderia thailandensis 3 0.7190
transketolase Q2SZA7 Q2SZA7_BURTA Burkholderia thailandensis 3 0.7190
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7189
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7189
Transketolase 1 P27302 TKT1_ECOLI Escherichia coli 3 0.7188
Transketolase 1 P27302 TKT1_ECOLI Escherichia coli 3 0.7188
Benzaldehyde lyase Q9F4L3 Q9F4L3_PSEFL Pseudomonas fluorescens 3 0.7180
Benzaldehyde lyase Q9F4L3 Q9F4L3_PSEFL Pseudomonas fluorescens 3 0.7180
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7179
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7179
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 3 0.7177
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 3 0.7177
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7171
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7171
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.7168
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.7168
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7166
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7166
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7161
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7161
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7149
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7149
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7145
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7145
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7145
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7145
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7141
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7141
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7140
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7140
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 3 0.7139
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7139
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7139
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 3 0.7139
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7137
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7137
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7135
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7135
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7134
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7134
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7133
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7133
Atlastin Q9VC57 ATLAS_DROME Drosophila melanogaster 3 0.7120
Atlastin Q9VC57 ATLAS_DROME Drosophila melanogaster 3 0.7120
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7118
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7118
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7117
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7117
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7110
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7110
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7103
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7103
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7103
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7103
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7100
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7100
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7096
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7096
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7072
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7072
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7069
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7069
Metallo-beta-lactamase type 2 P25910 BLAB_BACFG Bacteroides fragilis 3 0.7069
Metallo-beta-lactamase type 2 P25910 BLAB_BACFG Bacteroides fragilis 3 0.7069
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7066
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7066
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7066
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7066
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7063
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7063
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7062
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7062
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7059
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7059
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7058
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7058
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7058
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7058
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7057
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7057
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 2 0.7055
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 2 0.7055
Mitogen-activated protein kinase 13 O15264 MK13_HUMAN Homo sapiens 4 0.7045
Mitogen-activated protein kinase 13 O15264 MK13_HUMAN Homo sapiens 4 0.7045
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7032
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7032
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7025
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7025
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7021
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7021
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7016
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7016
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7015
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 3 0.7015
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7011
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7011
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7000
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7000

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