3',5'-dimethyl-2',4',6'-trihydroxychalcone - Compound Card

3',5'-dimethyl-2',4',6'-trihydroxychalcone

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3',5'-dimethyl-2',4',6'-trihydroxychalcone

Structure
Zoomed Structure
  • Family: Plantae - Annonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Chalcone
Canonical Smiles O=C(c1c(O)c(C)c(c(c1O)C)O)/C=C/c1ccccc1
InChI InChI=1S/C17H16O4/c1-10-15(19)11(2)17(21)14(16(10)20)13(18)9-8-12-6-4-3-5-7-12/h3-9,19-21H,1-2H3/b9-8+
InChIKey GOQDNYNXBMUBPA-CMDGGOBGSA-N
Formula C17H16O4
HBA 4
HBD 3
MW 284.31
Rotatable Bonds 3
TPSA 77.76
LogP 3.32
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 284.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Friesodielsia obovata Annonaceae Plantae 1202418

Showing of synonyms

  • Joseph CC, Magadula JJ, et al. (2007). A novel antiplasmodial 3',5'-diformylchalcone and other constituents of Friesodielsia obovata. Natural Product Research,2007,21(11),1009-1015. [View] [PubMed]
Pubchem: 52920300

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 284.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 284.31 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.59
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.71
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.21

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.83
Plasma Protein Binding
65.45
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.15
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.13
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.18
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
5.52
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.92
Rat (Acute)
2.39
Rat (Chronic Oral)
3.15
Fathead Minnow
4.58
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
393.91
Hydration Free Energy
-11.48
Log(D) at pH=7.4
3.02
Log(P)
4.94
Log S
-4.9
Log(Vapor Pressure)
-7.02
Melting Point
150.5
pKa Acid
5.43
pKa Basic
8.15
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9390
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9390
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9365
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9365
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 4 0.9362
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 4 0.9362
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9306
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9306
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9301
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9301
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9243
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9243
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 4 0.9101
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 4 0.9101
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8958
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8958
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8851
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8851
Carbonic anhydrase 13 Q8N1Q1 CAH13_HUMAN Homo sapiens 3 0.8848
Carbonic anhydrase 13 Q8N1Q1 CAH13_HUMAN Homo sapiens 3 0.8848
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8746
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8746
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8736
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8736
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8736
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8736
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8686
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8686
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.8620
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.8620
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8550
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8550
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.8516
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.8516
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8359
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8359
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8356
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8356
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8293
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8293
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8233
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8233
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8227
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8227
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8223
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8223
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8204
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8204
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8190
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8190
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8185
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8185
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8100
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8100
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8073
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8073
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8040
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8040
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8034
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8034
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8010
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8010
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7992
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7992
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7964
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7964
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7939
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7939
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7851
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7851
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7850
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7850
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7814
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7814
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7791
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7791
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 5 0.7790
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 5 0.7790
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7775
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7775
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7765
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7765
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7711
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7711
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7698
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7698
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.7675
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.7675
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7647
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7647
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7625
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7625
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7624
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7624
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7621
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7621
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7589
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7589
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7588
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7588
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7556
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7556
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7543
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7543
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7527
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7527
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7521
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7521
UDP-glycosyltransferase 72B1 Q9M156 U72B1_ARATH Arabidopsis thaliana 4 0.7516
UDP-glycosyltransferase 72B1 Q9M156 U72B1_ARATH Arabidopsis thaliana 4 0.7516
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7515
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7515
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7507
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7507
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7498
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7498
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7478
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7478
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7475
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7475
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 5 0.7459
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 5 0.7459
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7444
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7444
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7415
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7415
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7403
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7403
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7402
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7402
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7391
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7391
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7364
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7364
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7363
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7363
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7343
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7343
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7337
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7337
Albumin P02769 ALBU_BOVIN Bos taurus 3 0.7311
Albumin P02769 ALBU_BOVIN Bos taurus 3 0.7311
Deoxynucleoside kinase Q9XZT6 DNK_DROME Drosophila melanogaster 5 0.7295
Deoxynucleoside kinase Q9XZT6 DNK_DROME Drosophila melanogaster 5 0.7295
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7287
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7287
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7287
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7287
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7271
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7271
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7261
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7261
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7260
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7260
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7256
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7256
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7245
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7245
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7244
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7244
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 4 0.7242
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7242
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7242
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7242
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7242
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 4 0.7242
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7230
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7230
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7230
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7230
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7221
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7221
Cellular tumor antigen p53 P04637 P53_HUMAN Homo sapiens 3 0.7217
Cellular tumor antigen p53 P04637 P53_HUMAN Homo sapiens 3 0.7217
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7213
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7213
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.7212
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.7212
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7206
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7206
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7195
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7195
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7189
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7189
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7160
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7160
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7159
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7159
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7149
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7149
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7136
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7136
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7111
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7111
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7099
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7099
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7085
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7085
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7084
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7084
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7078
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7078
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7068
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7068
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7067
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7067
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7055
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7055
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7041
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7041
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7036
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7036
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7033
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7033
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7028
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7028
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7019
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7019
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7018
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7018
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7012
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7012
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7003
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7003
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7002
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7002
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7002
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7002
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7001
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7001

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