Demethoxymatteucinol - Compound Card

Demethoxymatteucinol

Select a section from the left sidebar

Demethoxymatteucinol

Structure
Zoomed Structure
  • Family: Plantae - Annonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles Cc1c2O[C@@H](CC(=O)c2c(c(c1O)C)O)c1ccccc1
InChI InChI=1S/C17H16O4/c1-9-15(19)10(2)17-14(16(9)20)12(18)8-13(21-17)11-6-4-3-5-7-11/h3-7,13,19-20H,8H2,1-2H3/t13-/m0/s1
InChIKey HAIHGFWQOPJMPV-ZDUSSCGKSA-N
Formula C17H16O4
HBA 4
HBD 2
MW 284.31
Rotatable Bonds 1
TPSA 66.76
LogP 3.42
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 284.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Friesodielsia obovata Annonaceae Plantae 1202418

Showing of synonyms

  • Joseph CC, Magadula JJ, et al. (2007). A novel antiplasmodial 3',5'-diformylchalcone and other constituents of Friesodielsia obovata. Natural Product Research,2007,21(11),1009-1015. [View] [PubMed]
Pubchem: 180550
Chebi: 70664
Nmrshiftdb2: 60029240
Metabolights: MTBLC70664
Bindingdb: 50278269

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 284.31 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 284.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 284.31 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.56
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.65
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.34

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.01
Plasma Protein Binding
84.46
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.72
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.8
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.93
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
5.91
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.92
Rat (Acute)
2.22
Rat (Chronic Oral)
2.46
Fathead Minnow
4.42
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
383.6
Hydration Free Energy
-8.62
Log(D) at pH=7.4
2.8
Log(P)
4.67
Log S
-4.43
Log(Vapor Pressure)
-7.86
Melting Point
156.22
pKa Acid
6.33
pKa Basic
6.55
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9715
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9715
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.9641
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.9641
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9619
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9619
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9424
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9424
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 4 0.9412
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 4 0.9412
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9406
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9406
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9360
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9360
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8988
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8988
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8980
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8980
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8865
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8865
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8792
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8792
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 4 0.8789
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 4 0.8789
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8730
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8730
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8719
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8719
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8707
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8707
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8668
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8668
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8663
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8663
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8658
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8658
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8592
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8592
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8572
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8572
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8549
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8549
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8543
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8543
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8542
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8542
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8530
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8530
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8519
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8519
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.8514
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.8514
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8512
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8512
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8504
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8504
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8503
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8503
Cytochrome P450 2C19 P33261 CP2CJ_HUMAN Homo sapiens 3 0.8477
Cytochrome P450 2C19 P33261 CP2CJ_HUMAN Homo sapiens 3 0.8477
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8474
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8474
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8439
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8439
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8425
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8425
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8396
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8396
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8392
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8392
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8382
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8382
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.8363
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.8363
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8360
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8360
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8342
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8342
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8341
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8341
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8297
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8297
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8280
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8280
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8276
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8276
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8260
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8260
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8252
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8252
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8217
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8217
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8196
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8196
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8180
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8180
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8179
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8179
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8150
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8150
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8124
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8124
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8121
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8121
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8110
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8110
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8106
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8106
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8104
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8104
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8066
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8066
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8056
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8056
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8054
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8054
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8042
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8042
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8031
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8031
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7996
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7996
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7985
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7985
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7922
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7922
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7912
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7912
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7910
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7910
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7906
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7906
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7905
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7905
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7900
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7900
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 4 0.7889
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 4 0.7889
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7886
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7886
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.7861
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.7861
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7854
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7854
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7851
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7851
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7841
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7841
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7838
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7838
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7836
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7836
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7836
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7836
Probable propionyl-CoA carboxylase beta chain 6 P9WQH5 PCC6_MYCTU Mycobacterium tuberculosis 4 0.7830
Probable propionyl-CoA carboxylase beta chain 6 P9WQH5 PCC6_MYCTU Mycobacterium tuberculosis 4 0.7830
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7812
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7812
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7811
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7811
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7808
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7808
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7804
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7804
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 3 0.7778
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 3 0.7778
AGAP001556-PA Q7PXT9 Q7PXT9_ANOGA Anopheles gambiae 3 0.7756
AGAP001556-PA Q7PXT9 Q7PXT9_ANOGA Anopheles gambiae 3 0.7756
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7746
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7746
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7733
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7733
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7718
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7718
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7711
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7711
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7709
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7709
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7698
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7698
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7696
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7696
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7686
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7686
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7683
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7683
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7668
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7668
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7663
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7663
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7644
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7644
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7595
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7595
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7586
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7586
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7576
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7576
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7571
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7571
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7561
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7561
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7561
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7561
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7557
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7557
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7542
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7542
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7522
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7522
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7508
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7508
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7502
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7502
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7499
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7499
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7496
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7496
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7487
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7487
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7478
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7478
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7468
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7468
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7460
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7460
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7451
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7451
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7449
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7449
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7432
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7432
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7422
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7422
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7410
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7410
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7371
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7371
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7370
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7370
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7369
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7369
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7355
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7355
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7353
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7353
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 4 0.7342
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 4 0.7342
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 4 0.7337
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 4 0.7337
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7333
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7333
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7332
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7332
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7326
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7326
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7316
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7316
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7306
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7306
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7303
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7303
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7290
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7290
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7288
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7288
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7283
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7283
Aryl hydrocarbon receptor nuclear translocator P53762 ARNT_MOUSE Mus musculus 4 0.7280
Aryl hydrocarbon receptor nuclear translocator P53762 ARNT_MOUSE Mus musculus 4 0.7280
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7276
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7276
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 4 0.7274
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 4 0.7274
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7273
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7273
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7264
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7264
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7263
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7263
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7261
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7261
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7255
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7255
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7253
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7253
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7249
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7249
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7245
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7245
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7243
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7243
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7230
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7230
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7209
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7209
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 4 0.7207
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 4 0.7207
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7204
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7204
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7198
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7198
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7198
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7198
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7193
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7193
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7177
Phosphoribosylformylglycinamidine synthase subunit PurL Q9X0X3 PURL_THEMA Thermotoga maritima 3 0.7177
Phosphoribosylformylglycinamidine synthase subunit PurL Q9X0X3 PURL_THEMA Thermotoga maritima 3 0.7177
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7177
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7154
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7154
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7142
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7142
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7140
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7140
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7139
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7139
Retinoic acid receptor RXR Q8T5C6 RXR_BIOGL Biomphalaria glabrata 3 0.7126
Retinoic acid receptor RXR Q8T5C6 RXR_BIOGL Biomphalaria glabrata 3 0.7126
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7126
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7126
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7125
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7125
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7121
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7121
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7119
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7119
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7118
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7118
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7112
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7112
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7098
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7098
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7092
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7092
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7085
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7085
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7082
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7082
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7076
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7076
Lanosterol 14-alpha demethylase A6ZSR0 A6ZSR0_YEAS7 Saccharomyces cerevisiae 3 0.7075
Lanosterol 14-alpha demethylase A6ZSR0 A6ZSR0_YEAS7 Saccharomyces cerevisiae 3 0.7075
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7073
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7073
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7065
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7065
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.7063
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.7063
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7061
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7061
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7059
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7059
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7057
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7057
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7055
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7055
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7042
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7042
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7041
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7041
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7040
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7040
Sterol 14-alpha demethylase Q7Z1V1 CP51_TRYCC Trypanosoma cruzi 4 0.7033
Sterol 14-alpha demethylase Q7Z1V1 CP51_TRYCC Trypanosoma cruzi 4 0.7033
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7030
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7030
Renin P00797 RENI_HUMAN Homo sapiens 4 0.7025
Renin P00797 RENI_HUMAN Homo sapiens 4 0.7025
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7000
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7000

Download SDF