Puguenolide - Compound Card

Puguenolide

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Puguenolide

Structure
Zoomed Structure
  • Family: Plantae - Annonaceae
  • Kingdom: Plantae
  • Class: Phenanthrenoid
    • Subclass: Pyrenone
Canonical Smiles COc1ccc2c3c1oc(=O)c1c3c(cc2)ccc1O
InChI InChI=1S/C16H10O4/c1-19-11-7-5-9-3-2-8-4-6-10(17)14-12(8)13(9)15(11)20-16(14)18/h2-7,17H,1H3
InChIKey SOTRBIZNTABHBB-UHFFFAOYSA-N
Formula C16H10O4
HBA 4
HBD 1
MW 266.25
Rotatable Bonds 1
TPSA 59.67
LogP 3.25
Number Rings 4
Number Aromatic Rings 4
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.06
Exact Mass 266.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Uvaria puguensis Annonaceae Plantae 174969

Showing of synonyms

  • Makangara JJ, Jonker SA, et al. (2002). A novel phenanthrenolide and C-benzyl dihydrochalcones from Uvaria puguensis. Natural Product Letters,2002,16(4),267-272. [View] [PubMed]
Pubchem: 129848736

No compound-protein relationship available.

Structure

SMILES: c12c3c4ccc2cccc1c(=O)oc3ccc4

Level: 0

Mol. Weight: 266.25 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.88
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.350
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.83

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.600
Plasma Protein Binding
79.0
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.470
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.310
Biodegradation
Toxic
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.670
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.510
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.340
Rat (Acute)
2.210
Rat (Chronic Oral)
2.130
Fathead Minnow
4.990
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
434.300
Hydration Free Energy
-10.340
Log(D) at pH=7.4
4.170
Log(P)
3.22
Log S
-6.38
Log(Vapor Pressure)
-7.53
Melting Point
185.51
pKa Acid
7.31
pKa Basic
2.52
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9736
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9736
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9255
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9255
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9236
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9236
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9176
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9176
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9161
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9161
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9126
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.9126
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9073
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9073
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9040
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9040
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8995
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8995
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8986
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8986
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8881
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8881
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8871
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8871
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8868
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8868
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8813
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8813
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8779
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8779
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8720
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8720
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8712
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8712
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8643
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8643
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8626
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8626
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8608
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8608
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8537
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8537
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8534
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8534
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8526
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8526
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 4 0.8479
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 4 0.8479
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8467
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8467
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.8435
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.8435
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8421
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8421
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8407
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8407
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8400
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8400
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8391
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8391
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8380
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8380
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8353
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8353
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8330
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8330
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8327
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8327
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8273
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8273
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8269
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8269
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8180
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8180
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8151
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8151
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8129
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8129
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8112
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8112
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8110
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8110
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8109
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8109
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8108
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8108
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8045
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8045
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8041
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8041
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8034
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8034
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8027
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8027
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8026
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8026
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7978
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7978
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7972
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7972
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7969
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7969
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7952
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7952
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7926
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7926
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7878
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7878
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7859
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7859
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7827
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7827
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7819
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7819
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.7810
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.7810
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7799
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7799
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7790
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7790
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7789
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7789
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7765
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7765
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7755
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7755
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7753
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7753
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7749
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7749
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.7738
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.7738
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7730
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7730
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7725
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7725
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7714
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7714
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7705
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7705
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7699
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7699
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7696
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7696
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7687
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7687
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7685
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7685
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7674
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7674
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7668
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7668
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7667
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7667
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7654
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7654
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7636
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7636
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7630
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7630
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7627
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7627
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7606
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.7606
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7574
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7574
UDP-glycosyltransferase 72B1 Q9M156 U72B1_ARATH Arabidopsis thaliana 4 0.7560
UDP-glycosyltransferase 72B1 Q9M156 U72B1_ARATH Arabidopsis thaliana 4 0.7560
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7537
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7537
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7501
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7501
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7499
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7499
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7487
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7487
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7485
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7485
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7453
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7453
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7452
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7452
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7445
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7445
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7442
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7442
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7426
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7426
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7409
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7409
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7406
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7406
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7402
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7402
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 4 0.7382
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 4 0.7382
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7377
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7377
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7365
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7365
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7363
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7363
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7363
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7363
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7357
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7357
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7354
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7354
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7353
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7353
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7349
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7349
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7346
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7346
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7337
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7337
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7304
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7304
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7302
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7302
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7291
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7291
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7278
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7278
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7270
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7270
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7269
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7269
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7263
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7263
Thymidylate synthase P07607 TYSY_MOUSE Mus musculus 4 0.7251
Thymidylate synthase P07607 TYSY_MOUSE Mus musculus 4 0.7251
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7236
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7236
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7223
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7223
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7207
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7207
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7205
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7205
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7200
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7200
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7194
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7194
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7188
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7188
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7183
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7183
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7175
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7175
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7173
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7173
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7173
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7173
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7167
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7167
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7166
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7166
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7164
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7164
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7162
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7162
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7161
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7161
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7160
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7160
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7159
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7159
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7157
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7157
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7144
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7144
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7130
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7130
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7129
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7129
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7128
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7128
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7126
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7126
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7107
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7107
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7105
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7105
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7093
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7093
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7088
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7088
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7084
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7084
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7077
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7077
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7074
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7074
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7073
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7073
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7066
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7066
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7063
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7063
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7060
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7060
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7052
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7052
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7048
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7048
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7039
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7039
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7036
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7036
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7036
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7036
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7030
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7030
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7030
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7030
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7028
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7028
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 3 0.7017
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 3 0.7017
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7014
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7014
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7014
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7014
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7012
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7012
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.7011
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.7011
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7006
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7006

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