Uvaretin - Compound Card

Uvaretin

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Uvaretin

Structure
Zoomed Structure
  • Family: Annonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Chalcone
Canonical Smiles COc1cc(O)c(c(c1C(=O)CCc1ccccc1)O)Cc1ccccc1O
InChI InChI=1S/C23H22O5/c1-28-21-14-20(26)17(13-16-9-5-6-10-18(16)24)23(27)22(21)19(25)12-11-15-7-3-2-4-8-15/h2-10,14,24,26-27H,11-13H2,1H3
InChIKey LQHGGFQNRNEFIG-UHFFFAOYSA-N
Formula C23H22O5
HBA 5
HBD 3
MW 378.42
Rotatable Bonds 7
TPSA 86.99
LogP 4.22
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 28
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 378.15
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Uvaria puguensis Annonaceae Plantae 174969
2 Uvaria species Annonaceae Plantae 174969
3 Uvaria leptocladon Annonaceae Plantae 673191
4 Uvaria tanzaniae Annonaceae Plantae 2695412

Showing of synonyms

  • Makangara JJ, Jonker SA, et al. (2002). A novel phenanthrenolide and C-benzyl dihydrochalcones from Uvaria puguensis. Natural Product Letters,2002,16(4),267-272. [View] [PubMed]
  • Nkunya MH, Weenen H, et al. (1991). Antimalarial activity of Tanzanian plants and their active constituents: the genus Uvaria.. Planta medica,1991,57(4),341-343. [View] [PubMed]
  • Nkunya MH, Weenen H, et al. (1993). Benzylated dihydrochalcones from Uvaria leptocladon.. Phytochemistry,1993,32(5),1297-1300. [View] [PubMed]
  • Weenen H, Nkunya MH, et al. (1991). Tanzanene, a spiro benzopyranyl sesquiterpene from Uvaria tanzaniae Verdc.. The Journal of Organic Chemistry,1991,56(20),5865-5867. [View] [PubMed]
Pubchem: 73447
Kegg Ligand: C09978
Chebi: 9915
Nmrshiftdb2: 60070708
Metabolights: MTBLC9915
CPRiL: 439036
Structure

SMILES: c1ccccc1CCC(=O)c2cc(ccc2)Cc3ccccc3

Level: 2

Mol. Weight: 300.4 g/mol

Structure

SMILES: c1ccccc1C(=O)CCc2ccccc2

Level: 1

Mol. Weight: 210.28 g/mol

Structure

SMILES: c1ccccc1Cc2ccccc2

Level: 1

Mol. Weight: 168.24 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

Antimalarial

Absorption

Caco-2 (logPapp)
-5.18
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.810
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.03

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.420
Plasma Protein Binding
83.56
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.180
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.400
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.140
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.990
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-7.040
Rat (Acute)
2.360
Rat (Chronic Oral)
3.350
Fathead Minnow
5.040
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
446.270
Hydration Free Energy
-7.660
Log(D) at pH=7.4
3.260
Log(P)
4.74
Log S
-6.08
Log(Vapor Pressure)
-8.59
Melting Point
126.26
pKa Acid
7.37
pKa Basic
7.27
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.9694
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.9694
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.9584
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 3 0.9584
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9546
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.9546
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9523
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9523
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9483
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9483
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9479
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9479
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.9439
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.9439
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9416
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9416
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.9404
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.9404
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.9396
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.9396
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.9396
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.9396
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.9387
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.9387
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.9352
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.9352
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.9338
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.9338
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9330
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9330
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.9305
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.9305
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9273
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9273
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.9271
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.9271
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9243
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9243
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9237
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9237
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9236
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9236
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q4WP27 Q4WP27_ASPFU Aspergillus fumigatus 3 0.9232
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q4WP27 Q4WP27_ASPFU Aspergillus fumigatus 3 0.9232
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 3 0.9228
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 3 0.9228
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.9222
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.9222
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 3 0.9221
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 3 0.9221
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9194
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9194
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.9192
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.9192
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9152
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9152
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9108
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9108
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.9078
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.9078
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.9074
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.9074
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 4 0.9071
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 4 0.9071
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9060
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9060
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.9057
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.9057
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 4 0.9056
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 4 0.9056
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.9054
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.9054
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.9049
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.9049
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9049
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9049
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9040
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9040
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.9024
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.9024
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.9014
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.9014
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.9009
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.9009
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.9001
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.9001
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8999
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8999
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8999
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8999
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.8990
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.8990
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8958
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8958
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8954
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8954
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8929
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8929
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8912
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8912
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8907
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8907
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.8895
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.8895
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 4 0.8890
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 4 0.8890
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.8882
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.8882
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8877
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8877
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8874
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8874
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8868
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8868
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8861
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8861
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8858
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8858
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.8848
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.8848
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q4WP27 Q4WP27_ASPFU Aspergillus fumigatus 3 0.8842
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q4WP27 Q4WP27_ASPFU Aspergillus fumigatus 3 0.8842
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.8826
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.8826
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8819
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8819
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8807
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8807
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.8801
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.8801
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8800
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8800
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8779
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8779
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8767
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8767
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8763
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8763
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8762
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8762
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8756
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8756
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.8709
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.8709
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8695
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8695
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8687
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8687
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8687
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8687
Geranylgeranyl transferase type-2 subunit alpha Q08602 PGTA_RAT Rattus norvegicus 3 0.8675
Geranylgeranyl transferase type-2 subunit alpha Q08602 PGTA_RAT Rattus norvegicus 3 0.8675
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8637
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.8637
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8637
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.8637
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8630
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8630
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8625
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8625
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8623
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8623
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.8621
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.8621
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8619
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8619
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8615
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8615
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.8599
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.8599
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8598
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8598
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 3 0.8597
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 3 0.8597
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8591
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8591
Cytochrome P450 107B1 A0R5U2 A0R5U2_MYCS2 Mycolicibacterium smegmatis155) 3 0.8584
Cytochrome P450 107B1 A0R5U2 A0R5U2_MYCS2 Mycolicibacterium smegmatis155) 3 0.8584
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8579
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8579
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8570
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8570
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8567
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8567
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8563
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8563
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8561
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8561
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8558
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8558
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8556
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8556
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 3 0.8538
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 3 0.8538
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8530
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8530
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8526
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8526
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8526
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8526
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.8524
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.8524
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 4 0.8507
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 4 0.8507
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8501
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8501
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.8499
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.8499
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8487
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8487
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8470
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8470
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8461
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8461
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8460
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8460
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 3 0.8458
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 3 0.8458
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8451
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8451
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8446
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8446
Sepiapterin reductase P35270 SPRE_HUMAN Homo sapiens 3 0.8413
Sepiapterin reductase P35270 SPRE_HUMAN Homo sapiens 3 0.8413
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8412
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8412
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8412
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8412
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8412
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8412
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8392
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8392
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8387
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8387
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8383
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8383
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 4 0.8379
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 4 0.8379
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8377
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8377
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8374
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8374
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8357
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8357
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 3 0.8354
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 3 0.8354
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8353
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8353
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8353
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8353
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8353
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8353
Bromodomain-containing protein 9 Q9H8M2 BRD9_HUMAN Homo sapiens 3 0.8347
Bromodomain-containing protein 9 Q9H8M2 BRD9_HUMAN Homo sapiens 3 0.8347
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8337
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8337
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 3 0.8334
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 3 0.8334
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8330
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8330
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8328
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8328
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.8318
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.8318
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8315
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8315
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8310
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8310
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8289
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8289
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8278
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8278
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8261
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8261
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8261
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8261
Ribosomal protein S6 kinase beta-1 P23443 KS6B1_HUMAN Homo sapiens 3 0.8256
Ribosomal protein S6 kinase beta-1 P23443 KS6B1_HUMAN Homo sapiens 3 0.8256
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.8253
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.8253
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8247
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8247
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8235
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8235
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8234
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8234
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8233
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8233
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8231
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8231
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8219
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8219
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8217
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8217
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8213
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8213
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8213
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8213
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8201
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8201
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8199
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8199
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8195
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8195
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.8191
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.8191
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8185
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8185
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8160
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8160
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8148
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8148
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 4 0.8137
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 4 0.8137
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.8127
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.8127
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8118
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8118
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8111
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8111
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8110
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8110
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8107
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8107
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8107
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8107
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8096
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8096
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8096
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8096
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.8095
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.8095
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8086
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8086
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8083
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8083
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.8080
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 5 0.8080
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8071
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8071
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8069
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8069
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8069
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8069
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8047
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8047
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8044
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8044
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 4 0.8042
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.8042
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.8042
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 4 0.8042
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8039
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8039
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8038
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8038
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.8025
Snake venom metalloproteinase atrolysin-D P15167 VM1AD_CROAT Crotalus atrox 3 0.8025
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.8025
Snake venom metalloproteinase atrolysin-D P15167 VM1AD_CROAT Crotalus atrox 3 0.8025
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.8024
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.8024
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.8006
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.8006
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7995
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7995
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7995
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7995
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7993
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7993
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.7992
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.7992
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 4 0.7989
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 4 0.7989
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7973
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7973
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7971
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7971
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7971
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7971
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7963
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7963
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7955
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7955
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7952
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7952
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7949
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7949
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7949
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7949
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7947
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7947
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7932
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7932
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7920
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7920
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7919
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7919
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 4 0.7913
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 4 0.7913
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7912
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7912
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7910
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7910
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 4 0.7910
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 4 0.7910
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7907
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7907
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7901
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7901
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7899
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7899
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7897
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7897
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7895
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7895
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 4 0.7876
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 4 0.7876
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 4 0.7874
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 4 0.7874
Probable nicotinate-nucleotide adenylyltransferase C3L5T6 NADD_BACAC Bacillus anthracis 3 0.7871
Probable nicotinate-nucleotide adenylyltransferase C3L5T6 NADD_BACAC Bacillus anthracis 3 0.7871
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7870
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7870
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7869
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7869
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7865
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7865
Kelch-like ECH-associated protein 1 Q14145 KEAP1_HUMAN Homo sapiens 3 0.7863
Kelch-like ECH-associated protein 1 Q14145 KEAP1_HUMAN Homo sapiens 3 0.7863
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7863
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7863
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 3 0.7856
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 3 0.7856
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7846
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7846
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7839
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7839
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7835
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7835
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7829
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7829
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7824
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7824
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7820
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7820
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7816
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7816
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7812
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7812
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7799
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7799
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 3 0.7796
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7796
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 3 0.7796
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7796
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7795
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7795
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7792
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7792
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7791
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7791
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7789
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7789
Histidinol dehydrogenase Q8G2R2 HISX_BRUSU Brucella suis biovar 1 3 0.7786
Histidinol dehydrogenase Q8G2R2 HISX_BRUSU Brucella suis biovar 1 3 0.7786
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7784
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7784
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7784
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7784
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7772
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7772
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7772
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7772
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7770
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7770
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7762
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7762
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7761
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7761
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7760
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7760
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 4 0.7754
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 4 0.7754
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 4 0.7750
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 4 0.7750
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7736
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7736
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7733
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7733
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7728
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7728
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7721
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7721
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7719
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7719
Type 4 fimbrial biogenesis protein PilM G3XD28 G3XD28_PSEAE Pseudomonas aeruginosa 3 0.7718
Type 4 fimbrial biogenesis protein PilM G3XD28 G3XD28_PSEAE Pseudomonas aeruginosa 3 0.7718
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7714
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7714
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7713
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7713
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7712
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7712
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7706
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7706
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7702
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7702
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7699
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7699
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7695
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7695
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7693
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7693
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7690
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7690
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7684
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 4 0.7684
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7684
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7684
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 3 0.7684
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 4 0.7684
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7676
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7676
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7675
Trimethylamine monooxygenase Q83XK4 Q83XK4_9GAMM Methylophaga aminisulfidivorans 3 0.7675
Trimethylamine monooxygenase Q83XK4 Q83XK4_9GAMM Methylophaga aminisulfidivorans 3 0.7675
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7675
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7673
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7673
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7671
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7671
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7668
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7668
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7658
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7658
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7657
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7657
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7656
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7656
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7654
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7654
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7650
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7650
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7648
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7648
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7636
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7636
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7633
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7633
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7632
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7632
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7630
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7630
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7625
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7625
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7624
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7624
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7619
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7619
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7618
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7618
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7612
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7612
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7610
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7610
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7608
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7608
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7606
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7606
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7603
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7603
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7600
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7600
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 3 0.7596
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 3 0.7596
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7593
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7593
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7591
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7591
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7588
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7588
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7587
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7587
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7586
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7586
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7584
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7584
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7579
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7579
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7578
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7578
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7577
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7577
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7574
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7574
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 3 0.7567
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 3 0.7567
Tyrosine-protein kinase ABL1 P00520 ABL1_MOUSE Mus musculus 4 0.7564
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7564
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7564
Tyrosine-protein kinase ABL1 P00520 ABL1_MOUSE Mus musculus 4 0.7564
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 4 0.7562
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 4 0.7562
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7561
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7561
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7558
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7558
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7558
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7558
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7551
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7551
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7551
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7551
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7548
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7548
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7548
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7548
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7543
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7543
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7538
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7538
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7537
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7537
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7534
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7534
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7526
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7526
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7523
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7523
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7523
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7523
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.7522
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.7522
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7518
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7518
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7513
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7513
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7513
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7513
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.7511
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.7511
Tyrosine-protein kinase ITK/TSK Q08881 ITK_HUMAN Homo sapiens 4 0.7505
Tyrosine-protein kinase ITK/TSK Q08881 ITK_HUMAN Homo sapiens 4 0.7505
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7504
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7504
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7502
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7502
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.7498
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.7498
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7496
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7496
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7495
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7495
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7492
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7492
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7492
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7492
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7488
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7488
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7488
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7488
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7486
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7486
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7485
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7485
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7483
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7483
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7483
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7483
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7483
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7483
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7481
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7481
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7478
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7478
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7478
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7478
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7477
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7477
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7476
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7476
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7475
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7475
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 3 0.7474
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 3 0.7474
Dihydroorotate dehydrogenase (quinone), mitochondrial Q63707 PYRD_RAT Rattus norvegicus 3 0.7470
Dihydroorotate dehydrogenase (quinone), mitochondrial Q63707 PYRD_RAT Rattus norvegicus 3 0.7470
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 4 0.7470
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 4 0.7470
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7469
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7469
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7462
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7462
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7461
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7461
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7460
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7460
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7458
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7458
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7457
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7457
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7456
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7456
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7454
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7454
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7454
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 3 0.7454
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 3 0.7454
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7454
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7454
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7454
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7452
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7452
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7452
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7452
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7447
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7447
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 3 0.7445
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 3 0.7445
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7444
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7444
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 3 0.7444
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 3 0.7444
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7438
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7438
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7434
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7434
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7431
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7431
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7428
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7428
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7425
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 3 0.7425
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 3 0.7425
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7425
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7421
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7421
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7416
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7416
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7408
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7408
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7408
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7408
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7408
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7408
5-formyltetrahydrofolate cyclo-ligase P75430 MTHFS_MYCPN Mycoplasma pneumoniae 2 0.7407
5-formyltetrahydrofolate cyclo-ligase P75430 MTHFS_MYCPN Mycoplasma pneumoniae 2 0.7407
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7405
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7405
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 4 0.7403
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 4 0.7403
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7402
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7402
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 4 0.7400
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 4 0.7400
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7396
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7396
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) P60472 UPPS_ECOLI Escherichia coli 3 0.7395
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) P60472 UPPS_ECOLI Escherichia coli 3 0.7395
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7391
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7391
Acyl-homoserine-lactone synthase Q4VSJ8 Q4VSJ8_BURGL Burkholderia glumae 4 0.7390
Acyl-homoserine-lactone synthase Q4VSJ8 Q4VSJ8_BURGL Burkholderia glumae 4 0.7390
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Q13526 PIN1_HUMAN Homo sapiens 4 0.7384
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Q13526 PIN1_HUMAN Homo sapiens 4 0.7384
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 2 0.7384
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 2 0.7384
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7383
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7383
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7382
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7382
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7381
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7381
Cytosol aminopeptidase P00727 AMPL_BOVIN Bos taurus 2 0.7380
Cytosol aminopeptidase P00727 AMPL_BOVIN Bos taurus 2 0.7380
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7380
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7380
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7378
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7378
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7375
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7375
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7374
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7374
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7372
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7372
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7367
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7367
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7367
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7367
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7367
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7367
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7366
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7366
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7355
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7355
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7354
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7354
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7352
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7352
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7348
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7348
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7341
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7341
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7340
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7340
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7334
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7334
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7331
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7331
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7331
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7331
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7329
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7329
Genome polyprotein O93077 O93077_9HEPC Hepacivirus hominis 3 0.7325
Genome polyprotein O93077 O93077_9HEPC Hepacivirus hominis 3 0.7325
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7316
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7316
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7314
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7314
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7314
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7314
Thymidylate kinase Q8I4S1 Q8I4S1_PLAF7 Plasmodium falciparum 4 0.7311
Thymidylate kinase Q8I4S1 Q8I4S1_PLAF7 Plasmodium falciparum 4 0.7311
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7310
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7310
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7309
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7309
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7305
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7305
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7301
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7301
Protease Q5RTL1 Q5RTL1_9HIV1 Human immunodeficiency virus 1 3 0.7298
Protease Q5RTL1 Q5RTL1_9HIV1 Human immunodeficiency virus 1 3 0.7298
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7297
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7297
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7296
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7296
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 4 0.7294
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 4 0.7294
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7293
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7293
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7293
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7293
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7292
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7292
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7291
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7291
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 3 0.7286
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7286
Glutamate receptor ionotropic, kainate 1 P22756 GRIK1_RAT Rattus norvegicus 3 0.7286
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7286
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7285
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7285
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.7280
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7280
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.7280
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7280
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7280
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7280
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7278
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7278
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7274
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7274
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7274
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7274
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7273
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7273
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7273
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7273
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7271
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7271
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7269
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7269
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7265
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7265
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 2 0.7264
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 2 0.7264
Cytosolic heat shock protein 90 Q7XJ80 Q7XJ80_HORVU Hordeum vulgare 3 0.7263
Cytosolic heat shock protein 90 Q7XJ80 Q7XJ80_HORVU Hordeum vulgare 3 0.7263
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7261
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7261
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7258
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7258
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7251
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7251
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7250
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7250
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 4 0.7248
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.7248
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 4 0.7248
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.7248
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7247
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7247
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7246
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7246
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7245
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7245
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7245
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7245
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7244
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7244
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7240
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7240
Glycylpeptide N-tetradecanoyltransferase 1 P30419 NMT1_HUMAN Homo sapiens 3 0.7238
Glycylpeptide N-tetradecanoyltransferase 1 P30419 NMT1_HUMAN Homo sapiens 3 0.7238
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7234
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7234
Anthranilate phosphoribosyltransferase P50384 TRPD_SACS2 Saccharolobus solfataricus 3 0.7233
Anthranilate phosphoribosyltransferase P50384 TRPD_SACS2 Saccharolobus solfataricus 3 0.7233
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7231
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7231
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7229
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7229
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7229
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7229
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7227
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7227
UDP-N-acetylenolpyruvoylglucosamine reductase P08373 MURB_ECOLI Escherichia coli 3 0.7226
UDP-N-acetylenolpyruvoylglucosamine reductase P08373 MURB_ECOLI Escherichia coli 3 0.7226
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7223
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7223
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7221
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7221
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7217
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7217
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7216
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7216
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7215
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7215
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7213
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7213
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7213
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7213
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7212
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7212
Prothrombin P00734 THRB_HUMAN Homo sapiens 4 0.7210
Prothrombin P00734 THRB_HUMAN Homo sapiens 4 0.7210
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7207
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7207
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7207
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7207
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7205
Bifunctional dihydrofolate reductase-thymidylate synthase D9N170 D9N170_PLAFA Plasmodium falciparum 3 0.7205
Bifunctional dihydrofolate reductase-thymidylate synthase D9N170 D9N170_PLAFA Plasmodium falciparum 3 0.7205
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7205
Pyruvate dehydrogenase E1 component P0AFG8 ODP1_ECOLI Escherichia coli 3 0.7200
Pyruvate dehydrogenase E1 component P0AFG8 ODP1_ECOLI Escherichia coli 3 0.7200
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.7199
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.7199
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7198
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7198
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7198
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7198
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 4 0.7197
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 4 0.7197
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7195
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7195
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7189
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7189
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7186
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7186
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7183
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7183
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7181
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7181
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7181
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7181
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7180
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7180
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7179
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7179
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 4 0.7175
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 4 0.7175
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7174
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 3 0.7174
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7173
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7173
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7169
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7169
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7168
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7168
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7168
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7168
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7167
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7167
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7164
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7164
High affinity nerve growth factor receptor P04629 NTRK1_HUMAN Homo sapiens 3 0.7159
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7159
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7159
High affinity nerve growth factor receptor P04629 NTRK1_HUMAN Homo sapiens 3 0.7159
Beta-lactamase P00811 AMPC_ECOLI Escherichia coli 3 0.7159
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7159
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7155
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.7155
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7153
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7153
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7147
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7147
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7145
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7145
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7142
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7142
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7142
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7142
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7141
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7141
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7141
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7141
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7140
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7140
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7139
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7139
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7139
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7139
Thymidylate synthase ThyA P9WFR9 TYSY_MYCTU Mycobacterium tuberculosis 3 0.7134
Thymidylate synthase ThyA P9WFR9 TYSY_MYCTU Mycobacterium tuberculosis 3 0.7134
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7130
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 4 0.7130
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7130
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7130
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 4 0.7130
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7130
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7126
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7126
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7125
Kelch-like ECH-associated protein 1 Q14145 KEAP1_HUMAN Homo sapiens 3 0.7125
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7125
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7125
Kelch-like ECH-associated protein 1 Q14145 KEAP1_HUMAN Homo sapiens 3 0.7125
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7125
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7124
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7124
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7124
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7124
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 2 0.7123
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 2 0.7123
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7122
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7122
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7117
Lipoprotein E P26093 HEL_HAEIN Haemophilus influenzae 3 0.7117
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7117
Lipoprotein E P26093 HEL_HAEIN Haemophilus influenzae 3 0.7117
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7116
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7116
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7114
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7114
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7114
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7114
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7113
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7113
Replicase polyprotein 1a P0C6U8 R1A_CVHSA Severe acute respiratory syndrome coronavirus 4 0.7107
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7107
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7107
Replicase polyprotein 1a P0C6U8 R1A_CVHSA Severe acute respiratory syndrome coronavirus 4 0.7107
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7107
Hydroxymethylglutaryl-CoA synthase Q9FD71 HMGCS_ENTFL Enterococcus faecalis 2 0.7107
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7103
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7103
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7101
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7101
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7101
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7101
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7101
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7101
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7099
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7099
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7098
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7098
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7097
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7097
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7092
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7092
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7091
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7091
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7087
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7087
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7085
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7085
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7084
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7084
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7084
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7084
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7083
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7083
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.7079
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.7079
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7078
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7078
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7077
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7077
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7072
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7072
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 2 0.7072
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 2 0.7072
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7070
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7070
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7069
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7069
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7069
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7069
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7067
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.7067
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7067
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7067
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.7067
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7067
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7066
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7066
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7065
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7065
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7062
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7062
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7061
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 3 0.7061
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 3 0.7061
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7061
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7060
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7060
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7060
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7060
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7059
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7059
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7059
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7059
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7057
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7057
6-phosphogluconate dehydrogenase, decarboxylating P96789 6PGD_LACLM Lactococcus lactis subsp. cremoris 3 0.7056
6-phosphogluconate dehydrogenase, decarboxylating P96789 6PGD_LACLM Lactococcus lactis subsp. cremoris 3 0.7056
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7056
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7056
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7055
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7055
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7054
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7054
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7052
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7052
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7050
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7050
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7049
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7049
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7049
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7049
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7046
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7046
Adenosine kinase P55263 ADK_HUMAN Homo sapiens 3 0.7043
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7043
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7043
Adenosine kinase P55263 ADK_HUMAN Homo sapiens 3 0.7043
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7043
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7043
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7037
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7037
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 4 0.7035
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 4 0.7035
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 2 0.7031
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 2 0.7031
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7026
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7026
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7025
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7025
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 4 0.7023
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.7023
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 4 0.7023
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.7023
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 4 0.7021
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7021
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7021
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7021
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 4 0.7021
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7021
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7021
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7021
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7020
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7020
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7020
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7020
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7019
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7019
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7019
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7019
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7016
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7016
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7015
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7015
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7012
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7012
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 4 0.7011
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7011
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7011
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7011
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 4 0.7011
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7011
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7011
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7011
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7011
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7011
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7008
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7008
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7006
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7006
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7005
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7005
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7003
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7003

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