Desacetyluvaricin - Compound Card

Desacetyluvaricin

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Desacetyluvaricin

Structure
Zoomed Structure
  • Family: Annonaceae
  • Kingdom: Plantae
  • Class: Acetogenin
Canonical Smiles CCCCCCCCCC[C@@H]([C@H]1CC[C@@H](O1)[C@H]1CC[C@@H](O1)[C@@H](CCCCCCCCCCCCC1=C[C@@H](OC1=O)C)O)O
InChI InChI=1S/C37H66O6/c1-3-4-5-6-7-13-16-19-22-31(38)33-24-26-35(42-33)36-27-25-34(43-36)32(39)23-20-17-14-11-9-8-10-12-15-18-21-30-28-29(2)41-37(30)40/h28-29,31-36,38-39H,3-27H2,1-2H3/t29-,31-,32+,33+,34+,35+,36+/m0/s1
InChIKey URLVCROWVOSNPT-HJPPHTJLSA-N
Formula C37H66O6
HBA 6
HBD 2
MW 606.93
Rotatable Bonds 25
TPSA 85.22
LogP 8.89
Number Rings 3
Number Aromatic Rings 0
Heavy Atom Count 43
Formal Charge 0
Fraction CSP3 0.92
Exact Mass 606.49
Number of Lipinski Rule Violations 2
# Species Family Kingdom NCBI Taxonomy ID
1 Ophrypetalum odoratum Annonaceae Plantae 489344

Showing of synonyms

  • Sung'hwa F, Mgina CA, et al. (1999). Ophrypetalin and other annonaceous acetogenins from Ophrypetalum odoratum. Natural Product Letters,1999,13(3),195-202. [View] [PubMed]
Pubchem: 127149
Nmrshiftdb2: 60075624
Bindingdb: 50094725
CPRiL: 233860
Structure

SMILES: O=C1OCC=C1CCCCCCCCCCCCCC2CCC(O2)C3CCCO3

Level: 2

Mol. Weight: 406.61 g/mol

Structure

SMILES: O1CCCC1CCCCCCCCCCCCCC2=CCOC2=O

Level: 1

Mol. Weight: 336.52 g/mol

Structure

SMILES: O1CCCC1C2CCCO2

Level: 1

Mol. Weight: 142.2 g/mol

Structure

SMILES: O=C1C=CCO1

Level: 0

Mol. Weight: 84.07 g/mol

Structure

SMILES: C1CCOC1

Level: 0

Mol. Weight: 72.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.91
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.73
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
9.24

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.78
Plasma Protein Binding
83.26
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Inhibitor

Excretion

Clearance
1.33
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
-1.45
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-1.38
Liver Injury II
Safe
hERG Blockers
Toxic
Daphnia Maga
5.09
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-23314.84
Rat (Acute)
2.71
Rat (Chronic Oral)
2.48
Fathead Minnow
45.49
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
803.54
Hydration Free Energy
-2.92
Log(D) at pH=7.4
5.32
Log(P)
10.15
Log S
-6.1
Log(Vapor Pressure)
-12.8
Melting Point
74.5
pKa Acid
9.9
pKa Basic
5.28
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9646
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9646
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9577
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9577
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.9560
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.9560
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9463
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9463
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.9445
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.9445
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.9409
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.9409
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9396
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9396
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9374
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9374
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9194
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9194
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9135
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9135
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.9134
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.9134
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.9064
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.9064
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.9061
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.9061
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.9060
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.9060
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 3 0.9010
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 3 0.9010
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8947
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8947
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8821
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8821
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8768
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8768
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8649
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8649
Gag-Pol polyprotein P0C6F2 POL_HV1LW Human immunodeficiency virus type 1 group M subtype B 3 0.8640
Gag-Pol polyprotein P0C6F2 POL_HV1LW Human immunodeficiency virus type 1 group M subtype B 3 0.8640
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8637
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8637
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8613
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8613
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8573
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8573
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.8538
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.8538
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8505
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8505
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8503
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8503
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8387
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8387
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8373
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8373
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8367
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8367
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8305
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8305
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8288
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8288
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8226
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8226
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 3 0.8197
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8197
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 3 0.8197
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8197
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8166
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8166
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8161
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8161
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8154
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8154
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.8153
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.8153
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 4 0.8108
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 4 0.8108
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 4 0.8105
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 4 0.8105
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8058
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8058
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8054
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8054
4-alpha-glucanotransferase O87172 MALQ_THETH Thermus thermophilus 3 0.8030
4-alpha-glucanotransferase O87172 MALQ_THETH Thermus thermophilus 3 0.8030
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.8027
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.8027
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8027
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8027
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.8016
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.8016
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.8007
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.8007
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7988
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7988
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7963
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7963
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7934
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7934
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7928
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7928
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7926
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7926
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7887
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7887
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7884
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7884
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7862
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7862
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7831
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7831
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7824
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7824
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7819
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7819
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.7801
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.7801
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7786
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7786
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7777
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7777
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7759
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7759
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7748
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7748
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7745
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7745
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7707
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7707
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7692
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7692
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7687
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7687
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7679
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7679
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7675
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7675
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7663
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7663
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 2 0.7658
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 2 0.7658
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7634
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7634
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7622
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7622
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7618
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7618
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7615
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7615
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7609
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7609
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7603
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7603
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7599
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7599
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7598
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7598
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7592
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7592
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7589
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7589
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7587
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7587
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7583
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7583
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7563
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7563
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7560
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7560
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7557
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7557
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7552
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7552
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7549
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7549
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7546
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7546
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7537
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7537
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7535
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7535
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7534
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7534
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7526
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7526
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7521
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7521
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7516
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7516
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.7514
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.7514
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7513
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7513
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7512
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7512
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7511
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7511
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7498
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7498
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7497
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7497
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7496
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7496
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 3 0.7495
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 3 0.7495
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7494
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7494
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7493
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7493
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7493
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7493
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7493
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7493
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7491
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7491
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 2 0.7487
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 2 0.7487
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7485
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7485
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7484
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7484
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7469
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7469
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7468
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7468
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7464
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7464
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7460
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7460
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7457
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7457
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7451
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7451
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7448
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7448
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7446
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7446
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7433
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7433
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7432
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7432
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7428
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7428
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7424
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7424
Gibberellin receptor GID1A Q9MAA7 GID1A_ARATH Arabidopsis thaliana 3 0.7420
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7420
Gibberellin receptor GID1A Q9MAA7 GID1A_ARATH Arabidopsis thaliana 3 0.7420
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7420
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7419
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7419
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7419
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7419
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7417
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7417
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7408
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7408
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7407
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7407
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7398
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7398
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7397
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7397
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7393
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7393
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7392
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7392
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7385
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7385
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7382
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7382
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7375
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.7375
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7372
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7372
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7372
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7372
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7361
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7361
Carnitine O-acetyltransferase P47934 CACP_MOUSE Mus musculus 2 0.7360
Carnitine O-acetyltransferase P47934 CACP_MOUSE Mus musculus 2 0.7360
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7350
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7350
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7344
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7344
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7339
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7339
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7329
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7329
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7328
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7328
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7326
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7326
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7310
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7310
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7307
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7307
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7306
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7306
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7299
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7299
Alanine aminotransferase Q9P9M8 Q9P9M8_9EURY Pyrococcus furiosus 2 0.7293
Alanine aminotransferase Q9P9M8 Q9P9M8_9EURY Pyrococcus furiosus 2 0.7293
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7284
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7284
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7282
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7282
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7280
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7280
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7279
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7279
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7277
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7277
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7257
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7257
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7246
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7246
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7245
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7245
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7235
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7235
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 3 0.7223
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 3 0.7223
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7213
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7213
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7203
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7203
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7198
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7198
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.7192
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.7192
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7181
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7181
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7171
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7171
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7163
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7163
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7138
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7138
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7135
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7135
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7131
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7131
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7123
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7123
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7116
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7116
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7110
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7110
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 3 0.7099
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 3 0.7099
Gibberellin receptor GID1 Q6L545 GID1_ORYSJ Oryza sativa subsp. japonica 3 0.7094
Gibberellin receptor GID1 Q6L545 GID1_ORYSJ Oryza sativa subsp. japonica 3 0.7094
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7060
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7060
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7040
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7040
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7034
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7034
Pyrrolysine--tRNA ligase Q8PWY1 PYLS_METMA Methanosarcina mazei 2 0.7033
Pyrrolysine--tRNA ligase Q8PWY1 PYLS_METMA Methanosarcina mazei 2 0.7033
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 3 0.7026
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 3 0.7026
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7021
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7021
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 2 0.7004
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 2 0.7004

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