Diphenylpentanoid (E)-1,5-bis(4-hydroxyphenyl)-pent-1-en-3-one - Compound Card

Diphenylpentanoid (E)-1,5-bis(4-hydroxyphenyl)-pent-1-en-3-one

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Diphenylpentanoid (E)-1,5-bis(4-hydroxyphenyl)-pent-1-en-3-one

Structure
Zoomed Structure
  • Family: Annonaceae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles O=C(/C=C/c1ccc(cc1)O)CCc1ccc(cc1)O
InChI InChI=1S/C17H16O3/c18-15-7-1-13(2-8-15)5-11-17(20)12-6-14-3-9-16(19)10-4-14/h1-5,7-11,18-19H,6,12H2/b11-5+
InChIKey JHRMROJFMCSWOU-VZUCSPMQSA-N
Formula C17H16O3
HBA 3
HBD 2
MW 268.31
Rotatable Bonds 5
TPSA 57.53
LogP 3.31
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 268.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Artabotrys modestus ssp. macranthus Annonaceae Plantae 225832

Showing of synonyms

  • Nyandoro SS, Joseph CC, et al. (2013). New antimicrobial, mosquito larvicidal and other metabolites from two Artabotrys species. Natural Product Research,2013,27(16),1450-458. [View] [PubMed]
Pubchem: 146600067

No compound-protein relationship available.

Structure

SMILES: c1ccccc1CCC(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 236.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

Anti-alzheimer

Absorption

Caco-2 (logPapp)
-4.86
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.52
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.4

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.8
Plasma Protein Binding
68.46
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.74
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.02
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.13
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.24
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
5.12
Rat (Acute)
1.58
Rat (Chronic Oral)
2.24
Fathead Minnow
4.58
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
406.81
Hydration Free Energy
-9.45
Log(D) at pH=7.4
3.14
Log(P)
2.75
Log S
-4.04
Log(Vapor Pressure)
-7.83
Melting Point
197.36
pKa Acid
9.71
pKa Basic
6.82
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9748
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9748
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.9695
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.9695
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9646
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9646
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9605
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9605
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9589
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9589
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9511
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9511
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.9476
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.9476
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9464
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9464
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9435
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9435
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9430
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9430
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9429
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9429
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.9422
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.9422
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.9420
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.9420
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9417
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9417
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9408
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9408
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9391
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9391
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.9390
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.9390
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9380
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9380
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9371
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9371
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.9335
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.9335
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9330
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9330
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.9248
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.9248
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.9219
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.9219
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9209
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9209
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9179
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9179
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9106
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9106
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9086
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9086
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9024
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9024
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8967
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8967
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8957
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8957
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8914
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8914
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8821
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8821
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8817
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8817
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8801
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8801
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8783
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8783
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8772
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8772
Avidin P02701 AVID_CHICK Gallus gallus 3 0.8768
Avidin P02701 AVID_CHICK Gallus gallus 3 0.8768
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8709
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8709
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8700
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8700
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.8697
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 3 0.8697
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.8675
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.8675
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8672
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8672
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8658
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8658
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.8646
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.8646
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8640
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8640
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8640
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8640
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8634
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8634
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8609
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8609
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8603
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8603
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8600
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8600
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8577
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8577
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8566
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8566
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8563
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8563
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8552
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8552
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8537
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8537
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8535
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8535
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8522
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8522
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.8518
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.8518
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8507
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8507
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8492
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8492
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8490
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8490
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8488
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8488
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8451
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8451
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8449
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8449
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8447
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8447
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.8446
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.8446
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.8437
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.8437
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8406
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8406
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8404
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8404
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8390
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8390
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8389
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8389
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8381
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8381
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8367
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8367
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8356
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8356
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8339
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8339
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8333
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8333
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.8313
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.8313
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8298
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8298
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8280
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8280
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8272
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8272
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8269
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8269
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8246
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8246
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.8245
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.8245
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8236
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8236
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8234
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8234
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8229
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8229
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8191
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8191
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8176
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8176
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8174
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8174
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8171
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8171
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.8149
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.8149
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8148
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8148
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8145
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8145
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8139
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8139
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.8106
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.8106
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8094
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8094
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8093
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.8093
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8093
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.8093
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8090
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8090
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8084
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.8084
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8082
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8082
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8079
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8079
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.8066
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.8066
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8045
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8045
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8043
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8043
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.8014
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.8014
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7995
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7995
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7992
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7992
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.7976
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.7976
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7970
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7970
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7960
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7960
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7955
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7955
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7952
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7952
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7945
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7945
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7939
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7939
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7938
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7938
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7931
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7931
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7931
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7931
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7918
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7918
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7909
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7909
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7908
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7908
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7901
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7901
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7894
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7894
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7866
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7866
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7863
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7863
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7862
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7862
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7860
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7860
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7859
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7859
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7852
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7852
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7849
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7849
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7835
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7835
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase P23970 MEND_BACSU Bacillus subtilis 3 0.7830
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase P23970 MEND_BACSU Bacillus subtilis 3 0.7830
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7826
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7826
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7814
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7814
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7810
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7810
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7802
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7802
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7800
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7800
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7796
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7796
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7795
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7795
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7791
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7791
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7790
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7790
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7774
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7774
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7770
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7770
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7770
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7770
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7756
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7756
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7753
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7753
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7746
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7746
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7746
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7746
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7739
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7739
Cystathionine beta-lyase MetC P06721 METC_ECOLI Escherichia coli 3 0.7738
Cystathionine beta-lyase MetC P06721 METC_ECOLI Escherichia coli 3 0.7738
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7737
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7737
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7736
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7736
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7735
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7735
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7733
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.7733
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.7731
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.7731
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7729
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7729
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7720
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7720
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7719
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7719
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7717
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7717
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7717
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7717
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7710
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7710
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7708
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7708
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7707
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7707
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7706
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7706
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7701
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7701
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7698
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7698
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7690
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7690
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7689
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7689
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7677
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7677
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7676
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7676
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 3 0.7675
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 3 0.7675
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7672
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7672
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7669
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7669
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7666
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7666
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7663
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7663
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7660
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7660
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7659
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7659
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7655
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7655
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7653
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7653
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7651
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7651
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7643
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7643
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7643
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7643
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7641
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7641
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7640
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.7640
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7640
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7640
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7638
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7638
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7634
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7634
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7633
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7633
Calmodulin-like domain protein kinase Q3HNM4 Q3HNM4_EIMTE Eimeria tenella 4 0.7632
Calmodulin-like domain protein kinase Q3HNM4 Q3HNM4_EIMTE Eimeria tenella 4 0.7632
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7630
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7630
Pyruvate dehydrogenase E1 component P0AFG8 ODP1_ECOLI Escherichia coli 3 0.7629
Pyruvate dehydrogenase E1 component P0AFG8 ODP1_ECOLI Escherichia coli 3 0.7629
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7626
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7626
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7626
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7626
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7626
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7626
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7626
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7626
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7625
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7625
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7615
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7615
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7612
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7612
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7608
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7608
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7593
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7593
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7593
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7593
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7591
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7591
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7587
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7587
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7579
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7579
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7571
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7571
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7569
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7569
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7562
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7562
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 2 0.7560
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 2 0.7560
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7554
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7554
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7554
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7554
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7551
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7551
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7550
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7550
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7550
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7550
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7549
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7549
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 2 0.7543
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 2 0.7543
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7542
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7542
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7540
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7540
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7537
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7537
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7532
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7532
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7531
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7531
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7530
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7530
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7530
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7530
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7530
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7530
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7528
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7528
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7526
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7526
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7523
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7523
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7521
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7521
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7520
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7520
High affinity nerve growth factor receptor P04629 NTRK1_HUMAN Homo sapiens 3 0.7519
High affinity nerve growth factor receptor P04629 NTRK1_HUMAN Homo sapiens 3 0.7519
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7518
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7518
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7517
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7517
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 3 0.7517
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 3 0.7517
Adenosine receptor A2a P29274 AA2AR_HUMAN Homo sapiens 4 0.7515
Adenosine receptor A2a P29274 AA2AR_HUMAN Homo sapiens 4 0.7515
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7514
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7514
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7514
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7514
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7513
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7513
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7512
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7512
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7510
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7510
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7509
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7509
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7508
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7508
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7499
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7499
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7496
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7496
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7492
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7492
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7491
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7491
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase P9WK11 MEND_MYCTU Mycobacterium tuberculosis 3 0.7487
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase P9WK11 MEND_MYCTU Mycobacterium tuberculosis 3 0.7487
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7483
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7483
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7482
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7482
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7481
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7481
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7478
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7478
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7477
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7477
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7476
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7476
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7473
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7473
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7472
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7472
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7469
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7469
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7469
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7469
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7468
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7468
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7468
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7468
Genome polyprotein A9LIE0 A9LIE0_9FLAV dengue virus type 3 3 0.7466
Genome polyprotein A9LIE0 A9LIE0_9FLAV dengue virus type 3 3 0.7466
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7462
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7462
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7454
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7454
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7452
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7452
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7450
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7450
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7450
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7450
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7446
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7446
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7446
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7446
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.7438
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7438
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7438
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.7438
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7436
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7436
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7433
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7433
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7433
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7433
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7432
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7432
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7430
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7430
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7426
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7426
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7426
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7426
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 2 0.7424
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 2 0.7424
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7420
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7420
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7416
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7416
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7415
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7415
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7414
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7414
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7412
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7412
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7405
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7405
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7403
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7403
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7400
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7400
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 3 0.7398
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 3 0.7398
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7397
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7397
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7394
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7394
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7393
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7393
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7393
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7393
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7389
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7389
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7388
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7388
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7387
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7387
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7387
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7387
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 3 0.7386
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7386
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 3 0.7386
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7386
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7384
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7384
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7378
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7378
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7375
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7375
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.7373
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.7373
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7371
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7371
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7370
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7370
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7369
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7369
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7368
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7368
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7365
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7365
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7363
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7363
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7362
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7362
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7361
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7361
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7358
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7358
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7356
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7356
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7356
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7356
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7353
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7353
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7353
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7353
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7347
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7347
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7347
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7347
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7346
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7346
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 3 0.7345
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 3 0.7345
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7344
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7344
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7343
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7343
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7339
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7339
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7339
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7339
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7337
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7337
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7337
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7337
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7336
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7336
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7334
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7334
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7333
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7333
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7333
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7333
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7332
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7332
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7332
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7332
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7332
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7332
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7330
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7330
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7330
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7330
Argininosuccinate synthase P59846 ASSY_THET8 Thermus thermophilus 3 0.7329
Argininosuccinate synthase P59846 ASSY_THET8 Thermus thermophilus 3 0.7329
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7328
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7328
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7328
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7328
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7327
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7327
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7323
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7323
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7319
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7319
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7319
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7319
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7317
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7317
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7316
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7316
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 2 0.7314
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 2 0.7314
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7313
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7313
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7307
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7307
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7307
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7307
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7307
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7307
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7306
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7306
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7305
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7305
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7304
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7304
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7303
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7303
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7301
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7301
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 3 0.7296
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 3 0.7296
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7295
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7295
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7291
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7291
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7291
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7291
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7288
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7288
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7287
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7287
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7285
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7285
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7283
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7283
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7281
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7281
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7281
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7281
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7277
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7277
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7272
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7272
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7270
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7270
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7269
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7269
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7269
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7269
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.7265
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.7265
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7264
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7264
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7264
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7264
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7262
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7262
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7261
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7261
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7258
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7258
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7258
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7258
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7258
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7258
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7258
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7258
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7257
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7257
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7257
Glycogen phosphorylase, liver form P06737 PYGL_HUMAN Homo sapiens 3 0.7257
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7252
UDP-3-O-acyl-N-acetylglucosamine deacetylase P47205 LPXC_PSEAE Pseudomonas aeruginosa 3 0.7252
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7252
UDP-3-O-acyl-N-acetylglucosamine deacetylase P47205 LPXC_PSEAE Pseudomonas aeruginosa 3 0.7252
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7252
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7252
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7251
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7251
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7249
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7249
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7248
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7248
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7246
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7246
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7246
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7246
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7245
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7245
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7243
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7243
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7242
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7242
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7242
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7242
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7242
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7242
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7241
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7241
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7241
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7241
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7238
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7238
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7237
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7237
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7237
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7237
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7236
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7236
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7232
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7232
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7230
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7230
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7229
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7229
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7227
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7227
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7226
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7226
Pol polyprotein Q90K99 Q90K99_9HIV1 Human immunodeficiency virus 1 3 0.7225
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7225
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7225
Pol polyprotein Q90K99 Q90K99_9HIV1 Human immunodeficiency virus 1 3 0.7225
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7222
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7222
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7221
Heat shock 70 kDa protein 1B P0DMV9 HS71B_HUMAN Homo sapiens 3 0.7221
Heat shock 70 kDa protein 1B P0DMV9 HS71B_HUMAN Homo sapiens 3 0.7221
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7221
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7220
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7220
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.7219
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.7219
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7219
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 3 0.7219
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7216
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7216
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7212
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7212
Thymidylate synthase ThyA P9WFR9 TYSY_MYCTU Mycobacterium tuberculosis 3 0.7210
Thymidylate synthase ThyA P9WFR9 TYSY_MYCTU Mycobacterium tuberculosis 3 0.7210
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7209
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7209
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7209
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7209
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7208
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7208
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7208
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7208
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7207
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7207
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7205
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7205
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7204
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7204
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7204
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7204
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7204
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7204
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7203
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7203
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7203
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7203
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7201
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7201
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7200
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7200
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7197
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7197
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7197
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7197
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7196
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7196
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7194
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7194
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7193
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7193
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7193
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7193
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7190
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7190
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7190
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7190
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7189
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7189
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7188
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7188
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7187
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7187
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7186
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7186
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7181
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7181
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7181
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7181
adenine phosphoribosyltransferase Q967M2 Q967M2_GIAIN Giardia intestinalis 2 0.7181
adenine phosphoribosyltransferase Q967M2 Q967M2_GIAIN Giardia intestinalis 2 0.7181
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7178
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7178
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7177
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7177
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7175
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7175
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7171
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7171
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7169
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7169
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 3 0.7169
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7169
UDP-3-O-acyl-N-acetylglucosamine deacetylase O67648 LPXC_AQUAE Aquifex aeolicus 2 0.7166
UDP-3-O-acyl-N-acetylglucosamine deacetylase O67648 LPXC_AQUAE Aquifex aeolicus 2 0.7166
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7165
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7165
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7165
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.7165
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7164
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7164
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7164
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7164
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7164
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7164
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7163
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7163
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7163
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7163
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7161
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7161
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7160
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7160
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7160
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7160
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7160
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7160
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7158
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7158
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7156
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7156
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7154
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7154
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7153
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7153
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7151
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7151
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7149
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7149
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7145
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7145
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7145
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7145
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7144
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7144
Genome polyprotein Q6YMS4 POLG_DEN3S Dengue virus type 3 3 0.7143
Genome polyprotein Q6YMS4 POLG_DEN3S Dengue virus type 3 3 0.7143
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7142
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 2 0.7142
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7141
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7141
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 3 0.7140
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 3 0.7140
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7138
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7138
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7137
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7137
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7135
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7135
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7131
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7131
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7131
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7131
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7130
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7130
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7129
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7129
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7129
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7129
L-methionine gamma-lyase Q84AR1 Q84AR1_CITFR Citrobacter freundii 3 0.7128
L-methionine gamma-lyase Q84AR1 Q84AR1_CITFR Citrobacter freundii 3 0.7128
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7127
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7127
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7126
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7126
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7125
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7125
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7124
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7124
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7123
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7123
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7122
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7122
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7122
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7122
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7120
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7120
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7118
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7118
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7118
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7118
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7115
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7115
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7115
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7115
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7110
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 2 0.7110
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7110
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7110
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7107
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7107
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7106
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7106
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7100
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7100
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7100
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7100
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7099
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7099
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7099
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 2 0.7099
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7098
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7098
Aminotransferase homolog Q9S5Y7 Q9S5Y7_CAMJU Campylobacter jejuni 3 0.7097
Aminotransferase homolog Q9S5Y7 Q9S5Y7_CAMJU Campylobacter jejuni 3 0.7097
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7095
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7095
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7094
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.7094
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7093
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7093
Catabolite activator protein C3SQJ7 C3SQJ7_ECOLX Escherichia coli 3 0.7092
Catabolite activator protein C3SQJ7 C3SQJ7_ECOLX Escherichia coli 3 0.7092
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7090
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7090
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7090
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7090
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7090
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7090
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7089
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7089
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7088
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7088
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7086
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 4 0.7086
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7086
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 4 0.7086
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7085
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7085
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7085
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7085
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7084
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7084
Tyrosine--tRNA ligase, cytoplasmic P54577 SYYC_HUMAN Homo sapiens 4 0.7084
Tyrosine--tRNA ligase, cytoplasmic P54577 SYYC_HUMAN Homo sapiens 4 0.7084
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7083
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7083
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7083
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7083
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7083
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7083
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7082
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.7082
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7082
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 3 0.7082
Thiamine-monophosphate kinase O67883 THIL_AQUAE Aquifex aeolicus 3 0.7081
Thiamine-monophosphate kinase O67883 THIL_AQUAE Aquifex aeolicus 3 0.7081
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.7077
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.7077
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7073
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7073
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7072
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7072
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7070
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7070
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7069
Kynurenine--oxoglutarate transaminase 1 Q16773 KAT1_HUMAN Homo sapiens 2 0.7069
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7065
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7065
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7065
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7065
Indole-3-pyruvate decarboxylase P23234 DCIP_ENTCL Enterobacter cloacae 3 0.7063
Indole-3-pyruvate decarboxylase P23234 DCIP_ENTCL Enterobacter cloacae 3 0.7063
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7060
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7060
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7060
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7060
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7057
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7057
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7056
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7056
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7055
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7055
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7052
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7052
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7052
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7052
Argininosuccinate synthase P59846 ASSY_THET8 Thermus thermophilus 3 0.7050
Argininosuccinate synthase P59846 ASSY_THET8 Thermus thermophilus 3 0.7050
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 3 0.7048
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 3 0.7048
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7045
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7045
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7045
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7045
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7045
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7045
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7043
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7043
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7041
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7041
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7039
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7039
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7039
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7039
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7038
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7038
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7038
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7038
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7037
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7037
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7032
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7032
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7031
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7031
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7031
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7031
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7030
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7030
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 2 0.7029
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 2 0.7029
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7027
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7027
Polymerase basic protein 2 Q2LG68 Q2LG68_9INFA Influenza A virus) 4 0.7026
Polymerase basic protein 2 Q2LG68 Q2LG68_9INFA Influenza A virus) 4 0.7026
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7025
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 4 0.7025
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7024
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7024
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7023
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7023
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7021
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7021
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7019
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7019
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7019
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7019
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7016
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7016
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7014
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7014
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7013
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7013
Cell division protein FtsZ P0A031 FTSZ_STAAU Staphylococcus aureus 3 0.7013
Cell division protein FtsZ P0A031 FTSZ_STAAU Staphylococcus aureus 3 0.7013
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7011
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7011
Cell division protein FtsZ P0A029 FTSZ_STAAM Staphylococcus aureus 3 0.7008
Cell division protein FtsZ P0A029 FTSZ_STAAM Staphylococcus aureus 3 0.7008
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7007
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7007
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7006
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7006
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7006
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7006
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7006
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7006
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7006
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7006
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7004
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7004
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7004
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7004
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7004
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7004
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7003
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7003
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7002
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7002

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