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Epimonanthadiepoxide

Family: Plantae - Annonaceae
Kingdom: Plantae
Class: Cyclohexane Derivative
- Subclass: Oxygenated Cyclohexane Epoxide Derivative

Canonical Smiles	O=C(c1ccccc1)OC[C@@]12OC2C2C([C@@H]([C@H]1O)OC(=O)c1ccccc1)O2
InChI	InChI=1S/C21H18O7/c22-17-15(27-20(24)13-9-5-2-6-10-13)14-16(26-14)18-21(17,28-18)11-25-19(23)12-7-3-1-4-8-12/h1-10,14-18,22H,11H2/t14?,15-,16?,17+,18?,21+/m0/s1
InChIKey	ALMRCTAYFWTPPM-KIVQZMDESA-N
Formula	C₂₁H₁₈O₇
HBA	7
HBD	1
MW	382.37
Rotatable Bonds	5
TPSA	97.89
LogP	1.35
Number Rings	5
Number Aromatic Rings	2
Heavy Atom Count	28
Formal Charge	0
Fraction CSP3	0.33
Exact Mass	382.11
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Monanthotaxis buchananii	Annonaceae	Plantae	1202420

Showing of synonyms

Liang G-Y, Gray AI, et al. (1988). Polyoxygenated cyclohexane epoxide derivatives from the stem bark of Monanthotaxis buchananii. Phytochemistry,1988,27(12),3857-3860. [View] [PubMed]

No compound-protein relationship available.

SMILES: c1ccccc1C(=O)OCC23C(O3)C4C(O4)C(C2)OC(=O)c5ccccc5

Level: 2

Mol. Weight: 382.37 g/mol

SMILES: c1ccccc1C(=O)OCC23C(O3)C4C(O4)CC2

Level: 1

Mol. Weight: 382.37 g/mol

SMILES: c1ccccc1C(=O)OC(C2O3)CC(O4)C4C23

Level: 1

Mol. Weight: 382.37 g/mol

SMILES: C12C3C(O3)CCC1O2

Level: 0

Mol. Weight: 382.37 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 382.37 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.9
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.5
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -3.28

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.78
Plasma Protein Binding: 40.94
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 11.36
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.1
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.83
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.82
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -38.09
Rat (Acute): 3.43
Rat (Chronic Oral): 2.09
Fathead Minnow: 4.53
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 406.51
Hydration Free Energy: -3.96
Log(D) at pH=7.4: 1.91
Log(P): 2.27
Log S: -4.02
Log(Vapor Pressure): -8.02
Melting Point: 111.26
pKa Acid: 5.93
pKa Basic: -4.29

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.9652
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.9652
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9438
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9438
Bifunctional protein GlmU	P43889	GLMU_HAEIN	Haemophilus influenzae	3	0.9338
Bifunctional protein GlmU	P43889	GLMU_HAEIN	Haemophilus influenzae	3	0.9338
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.9233
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.9233
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.9212
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.9212
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9044
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9044
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8952
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8952
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8886
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8886
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8753
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8753
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8616
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8616
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8574
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8574
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8563
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8563
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8469
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8469
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.8370
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.8370
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8337
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8337
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	4	0.8255
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	4	0.8255
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.8250
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.8250
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8242
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8242
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8222
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8222
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8069
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8069
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8062
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8062
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7936
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7936
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7870
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7870
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	4	0.7854
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	4	0.7854
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7809
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7809
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	5	0.7697
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	5	0.7697
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7690
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7690
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7636
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7636
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.7627
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.7627
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	3	0.7612
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	3	0.7612
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7592
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7592
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7585
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7585
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7573
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7573
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7573
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7573
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7557
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7557
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7542
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7542
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7534
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7534
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7504
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7504
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7488
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7488
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7469
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7469
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7419
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7419
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7418
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7418
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7411
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7411
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7396
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7396
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7395
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7395
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7389
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7389
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7381
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7381
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7372
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7372
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7365
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7365
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7351
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7351
Elastase	P14756	ELAS_PSEAE	Pseudomonas aeruginosa	5	0.7350
Elastase	P14756	ELAS_PSEAE	Pseudomonas aeruginosa	5	0.7350
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7344
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7344
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7340
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7340
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7332
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7332
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7308
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7308
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7308
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7308
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	2	0.7303
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	2	0.7303
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7296
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7296
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7261
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7261
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7250
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7250
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.7248
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.7248
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7241
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7241
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7235
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7235
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7229
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7229
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7222
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7222
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7210
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7210
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7210
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7210
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7206
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7206
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7205
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7205
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7197
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7197
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7186
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7186
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7176
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7176
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.7175
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.7175
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7173
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7173
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7168
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7168
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.7154
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.7154
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	4	0.7148
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	4	0.7148
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7145
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7145
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	4	0.7123
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	4	0.7123
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7120
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7120
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7101
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7101
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7099
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7099
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7099
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7099
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7090
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7090
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7084
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7084
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7083
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7083
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7083
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7083
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7082
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7082
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7080
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7080
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7078
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7078
Kelch-like ECH-associated protein 1	Q14145	KEAP1_HUMAN	Homo sapiens	3	0.7076
Kelch-like ECH-associated protein 1	Q14145	KEAP1_HUMAN	Homo sapiens	3	0.7076
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7074
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7074
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7071
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7071
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7063
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7063
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7028
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7028
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7015
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7015
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7014
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7014
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7001
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7001
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7000
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7000

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