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Epimonanthadiepoxide chlorhydrin

Family: Annonaceae
Kingdom: Plantae
Class: Cyclohexane Derivative
- Subclass: Oxygenated Cyclohexane Epoxide Derivative

Canonical Smiles	O=C(c1ccccc1)OC[C@]12O[C@@H]2[C@H]([C@@H]([C@@H]([C@H]1O)OC(=O)c1ccccc1)O)Cl
InChI	InChI=1S/C21H19ClO7/c22-14-15(23)16(28-20(26)13-9-5-2-6-10-13)17(24)21(18(14)29-21)11-27-19(25)12-7-3-1-4-8-12/h1-10,14-18,23-24H,11H2/t14-,15-,16-,17+,18+,21-/m0/s1
InChIKey	WASYKEZBYFQRGZ-FKAVEWNRSA-N
Formula	C₂₁H₁₉ClO₇
HBA	7
HBD	2
MW	418.83
Rotatable Bonds	5
TPSA	105.59
LogP	1.55
Number Rings	4
Number Aromatic Rings	2
Heavy Atom Count	29
Formal Charge	0
Fraction CSP3	0.33
Exact Mass	418.08
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Monanthotaxis buchananii	Annonaceae	Plantae	1202420

Showing of synonyms

Liang G-Y, Gray AI, et al. (1988). Polyoxygenated cyclohexane epoxide derivatives from the stem bark of Monanthotaxis buchananii. Phytochemistry,1988,27(12),3857-3860. [View] [PubMed]

No compound-protein relationship available.

SMILES: c1ccccc1C(=O)OCC23C(O3)CCC(C2)OC(=O)c4ccccc4

Level: 2

Mol. Weight: 352.39 g/mol

SMILES: c1ccccc1C(=O)OCC23C(O3)CCCC2

Level: 1

Mol. Weight: 232.28 g/mol

SMILES: c1ccccc1C(=O)OC(C2)CCC(O3)C23

Level: 1

Mol. Weight: 218.25 g/mol

SMILES: C12C(O2)CCCC1

Level: 0

Mol. Weight: 98.15 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -5.23
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.68
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -3.09

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.89
Plasma Protein Binding: 50.99
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 9.19
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.38
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.15
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.31
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -37.49
Rat (Acute): 3.26
Rat (Chronic Oral): 2.61
Fathead Minnow: 4.14
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 409.96
Hydration Free Energy: -3.67
Log(D) at pH=7.4: 1.79
Log(P): 2.67
Log S: -3.77
Log(Vapor Pressure): -9.01
Melting Point: 135.33
pKa Acid: 6.04
pKa Basic: -3.33

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9579
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9579
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9515
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9515
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.9435
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.9435
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9384
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9384
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9293
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9293
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.9226
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.9226
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9225
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9225
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.9202
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.9202
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.9193
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.9193
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.9121
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.9121
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8991
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8991
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8894
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.8894
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	3	0.8879
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	3	0.8879
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8744
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8744
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.8623
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.8623
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8581
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8581
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.8533
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.8533
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8516
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8516
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8450
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8450
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	3	0.8399
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	3	0.8399
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8338
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8338
Botulinum neurotoxin type A	P0DPI0	BXA1_CLOBO	Clostridium botulinum	3	0.8282
Botulinum neurotoxin type A	P0DPI0	BXA1_CLOBO	Clostridium botulinum	3	0.8282
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.8277
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.8277
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.8236
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.8236
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8152
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8152
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8099
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8099
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.8072
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.8072
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8038
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8038
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	3	0.7997
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	3	0.7997
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7921
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7921
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7896
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7896
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7844
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7844
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7820
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7820
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7813
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7813
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7798
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7798
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7735
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7735
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7729
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7729
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7702
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7702
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.7642
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.7642
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7638
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7638
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7623
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7623
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.7621
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.7621
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7612
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7612
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.7609
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.7609
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7609
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7609
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7603
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7603
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7598
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7598
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7570
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7570
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7554
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7554
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7545
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7545
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.7539
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.7539
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7501
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7501
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7500
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7500
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7497
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7497
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7494
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7494
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7492
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7492
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7476
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7476
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7469
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7469
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7461
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7461
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7455
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7455
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7452
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7452
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	3	0.7439
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	3	0.7439
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7437
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7437
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	2	0.7428
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	2	0.7428
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7423
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7423
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7415
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7415
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7406
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7406
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7401
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7401
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.7383
Gag-Pol polyprotein	P0C6F2	POL_HV1LW	Human immunodeficiency virus type 1 group M subtype B	3	0.7383
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7362
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7362
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7355
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7355
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7350
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7350
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7342
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7342
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7342
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7342
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7336
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7336
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	2	0.7334
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	2	0.7334
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7333
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7333
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7332
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7332
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	3	0.7323
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	3	0.7323
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7321
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7321
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7320
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7320
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7317
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7317
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7313
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7313
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7313
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7313
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7309
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7309
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7287
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7287
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7284
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7284
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7282
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7282
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7276
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7276
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7272
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7272
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7265
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7265
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7264
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7264
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7256
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7256
Cystathionine beta-lyase MetC	P06721	METC_ECOLI	Escherichia coli	3	0.7253
Cystathionine beta-lyase MetC	P06721	METC_ECOLI	Escherichia coli	3	0.7253
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7251
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7251
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7248
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7248
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7245
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7245
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7244
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7244
Penicillin V acylase	P12256	PAC_LYSSH	Lysinibacillus sphaericus	3	0.7241
Penicillin V acylase	P12256	PAC_LYSSH	Lysinibacillus sphaericus	3	0.7241
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7206
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7206
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7204
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7204
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.7203
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.7203
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7198
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7198
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7196
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7196
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7185
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7185
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7184
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7184
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7179
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7179
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7168
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7168
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7155
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7155
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7143
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7143
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7139
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7139
Tryptase alpha/beta-1	Q15661	TRYB1_HUMAN	Homo sapiens	3	0.7138
Tryptase alpha/beta-1	Q15661	TRYB1_HUMAN	Homo sapiens	3	0.7138
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7135
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7135
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7133
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7133
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	2	0.7124
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	2	0.7124
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7122
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7122
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7122
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7122
Carbonic anhydrase	Q39588	Q39588_CHLRE	Chlamydomonas reinhardtii	2	0.7110
Carbonic anhydrase	Q39588	Q39588_CHLRE	Chlamydomonas reinhardtii	2	0.7110
Orf1ab polyprotein	Q6T1E9	Q6T1E9_CVHSA	SARS coronavirus CUHK-L2	3	0.7100
Orf1ab polyprotein	Q6T1E9	Q6T1E9_CVHSA	SARS coronavirus CUHK-L2	3	0.7100
Ribosome-inactivating protein alpha-trichosanthin	P09989	RIPT_TRIKI	Trichosanthes kirilowii	3	0.7092
Ribosome-inactivating protein alpha-trichosanthin	P09989	RIPT_TRIKI	Trichosanthes kirilowii	3	0.7092
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7087
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7087
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7083
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7083
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.7082
Diphtheria toxin	P00588	DTX_CORBE	Corynephage beta	3	0.7082
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7076
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7076
Heat shock cognate 71 kDa protein	P11142	HSP7C_HUMAN	Homo sapiens	3	0.7074
Heat shock cognate 71 kDa protein	P11142	HSP7C_HUMAN	Homo sapiens	3	0.7074
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7072
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7072
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7069
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7069
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7066
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7066
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	4	0.7056
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	4	0.7056
O-GlcNAcase BT_4395	Q89ZI2	OGA_BACTN	Bacteroides thetaiotaomicron	4	0.7054
O-GlcNAcase BT_4395	Q89ZI2	OGA_BACTN	Bacteroides thetaiotaomicron	4	0.7054
Bifunctional protein GlmU	P43889	GLMU_HAEIN	Haemophilus influenzae	3	0.7053
Bifunctional protein GlmU	P43889	GLMU_HAEIN	Haemophilus influenzae	3	0.7053
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7042
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7042
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7021
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7021
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7019
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7019
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7015
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7015
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	4	0.7009
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	4	0.7009
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	2	0.7003
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	2	0.7003

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