Z-toussaintine E - Compound Card

Z-toussaintine E

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Z-toussaintine E

Structure
Zoomed Structure
  • Family: Annonaceae
  • Kingdom: Plantae
  • Class: N-Cinnamoyltetraketide
Canonical Smiles COC(=O)C[C@]1(O)C=CC(=O)CC1NC(=O)/C=C\c1ccccc1
InChI InChI=1S/C18H19NO5/c1-24-17(22)12-18(23)10-9-14(20)11-15(18)19-16(21)8-7-13-5-3-2-4-6-13/h2-10,15,23H,11-12H2,1H3,(H,19,21)/b8-7-/t15?,18-/m1/s1
InChIKey WTPJVIGCNHPGKJ-YYKLKOAVSA-N
Formula C18H19NO5
HBA 5
HBD 2
MW 329.35
Rotatable Bonds 5
TPSA 92.7
LogP 1.01
Number Rings 2
Number Aromatic Rings 1
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.28
Exact Mass 329.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Toussaintia orientalis Annonaceae Plantae 489350

Showing of synonyms

  • Nyandoro SS, Ndanu J, et al. (2015). N-Cinnamoyltetraketide derivatives from the leaves of Toussaintia orientalis. Journal of Natural Products,2015,78(8),2045-2050. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: O=C1C=CCC(C1)NC(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 241.29 g/mol

Structure

SMILES: O=C1C=CCCC1

Level: 0

Mol. Weight: 96.13 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

Antimycobacterial

Absorption

Caco-2 (logPapp)
-4.82
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.380
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.47

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.340
Plasma Protein Binding
48.57
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.740
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.540
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.150
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.800
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-3.000
Rat (Acute)
2.490
Rat (Chronic Oral)
2.530
Fathead Minnow
4.020
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
396.660
Hydration Free Energy
-13.910
Log(D) at pH=7.4
1.140
Log(P)
1.39
Log S
-2.67
Log(Vapor Pressure)
-7.56
Melting Point
144.59
pKa Acid
9.38
pKa Basic
6.25
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.9433
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.9433
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.9340
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 3 0.9340
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.9138
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.9138
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9037
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9037
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8924
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8924
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.8772
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.8772
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8684
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8684
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8652
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8652
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8562
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8562
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8541
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8541
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8481
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8481
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8429
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8429
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8417
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8417
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8414
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8414
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8398
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8398
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8372
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8372
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8350
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8350
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8346
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8346
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8341
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8341
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8278
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8278
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8262
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8262
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8257
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8257
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8164
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8164
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8054
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8054
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8002
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8002
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7997
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7997
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 3 0.7906
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 3 0.7906
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7887
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7887
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 3 0.7854
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 3 0.7854
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7851
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7851
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7832
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7832
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7818
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7818
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7794
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7794
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7696
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7696
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7670
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7670
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7670
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7670
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.7657
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.7657
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7630
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7630
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7618
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7618
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7577
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7577
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7569
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7569
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7564
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7564
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7557
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7557
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7552
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7552
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7537
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7537
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7535
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7535
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7535
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7535
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7533
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7533
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7510
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7510
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7507
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7507
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7489
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7489
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7484
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7484
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7452
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7452
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7446
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7446
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7440
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7440
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7430
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7430
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7429
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7429
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7409
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7409
Karilysin D0EM77 KLY_TANFA Tannerella forsythia 2 0.7407
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7407
Karilysin D0EM77 KLY_TANFA Tannerella forsythia 2 0.7407
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7407
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7402
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7402
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7399
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7399
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7348
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7348
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7345
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7345
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7344
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7344
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7337
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7337
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7336
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7336
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7319
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7319
Antibiotic ABC transporter, ATP-binding protein, putative Q9X1C3 Q9X1C3_THEMA Thermotoga maritima 3 0.7315
Antibiotic ABC transporter, ATP-binding protein, putative Q9X1C3 Q9X1C3_THEMA Thermotoga maritima 3 0.7315
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7312
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7312
Iota toxin component Ia Q46220 Q46220_CLOPF Clostridium perfringens 3 0.7310
Iota toxin component Ia Q46220 Q46220_CLOPF Clostridium perfringens 3 0.7310
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7296
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7296
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7292
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7292
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7292
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7292
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7287
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7287
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.7279
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 3 0.7279
Adenosine 5'-monophosphoramidase HINT1 P80912 HINT1_RABIT Oryctolagus cuniculus 3 0.7275
Adenosine 5'-monophosphoramidase HINT1 P80912 HINT1_RABIT Oryctolagus cuniculus 3 0.7275
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7273
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7273
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7251
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7251
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7251
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7251
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7249
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7249
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 3 0.7246
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 3 0.7246
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7243
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7243
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7240
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7240
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7235
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.7235
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7227
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7227
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7224
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7224
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7215
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7215
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7211
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7211
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7207
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7207
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7203
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7203
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7202
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7202
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7196
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7196
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7193
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7193
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 2 0.7188
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 2 0.7188
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7178
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7178
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7177
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7177
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7167
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7167
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7146
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7146
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7133
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7133
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7130
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7130
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 2 0.7115
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 2 0.7115
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7113
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7113
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7108
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7108
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7093
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7093
Glucosamine-6-phosphate deaminase P0A759 NAGB_ECOLI Escherichia coli 3 0.7090
Glucosamine-6-phosphate deaminase P0A759 NAGB_ECOLI Escherichia coli 3 0.7090
Pyridine nucleotide-disulfide oxidoreductase, class I A0A6L7H7X4 A0A0F7RMY2_BACAN Bacillus anthracis 3 0.7089
Pyridine nucleotide-disulfide oxidoreductase, class I A0A6L7H7X4 A0A0F7RMY2_BACAN Bacillus anthracis 3 0.7089
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7088
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7088
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7085
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7085
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 3 0.7081
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 3 0.7081
Mannosylglycerate synthase D0MI02 D0MI02_RHOM4 Rhodothermus marinus 3 0.7078
Mannosylglycerate synthase D0MI02 D0MI02_RHOM4 Rhodothermus marinus 3 0.7078
Penicillin V acylase P12256 PAC_LYSSH Lysinibacillus sphaericus 3 0.7060
Penicillin V acylase P12256 PAC_LYSSH Lysinibacillus sphaericus 3 0.7060
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7049
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7049
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 3 0.7045
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 3 0.7045
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7043
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7043
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7033
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7033
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7033
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7033
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7030
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7030
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7030
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7030
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7004
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7004

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