ANPDB

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(+)-pipoxide

Family: Plantae - Annonaceae
Kingdom: Plantae
Class: Cyclohexane Derivative
- Subclass: Oxygenated Cyclohexane Epoxide Derivative

Canonical Smiles	O=C(c1ccccc1)OC[C@@]12OC1C=C[C@H]([C@@H]2O)OC(=O)c1ccccc1
InChI	InChI=1S/C21H18O6/c22-18-16(26-20(24)15-9-5-2-6-10-15)11-12-17-21(18,27-17)13-25-19(23)14-7-3-1-4-8-14/h1-12,16-18,22H,13H2/t16-,17?,18+,21-/m1/s1
InChIKey	BHNSEWKVMCNSGO-PJNGNRRGSA-N
Formula	C₂₁H₁₈O₆
HBA	6
HBD	1
MW	366.37
Rotatable Bonds	5
TPSA	85.36
LogP	2.14
Number Rings	4
Number Aromatic Rings	2
Heavy Atom Count	27
Formal Charge	0
Fraction CSP3	0.24
Exact Mass	366.11
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Monanthotaxis buchananii	Annonaceae	Plantae	1202420

Showing of synonyms

Liang G-Y, Gray AI, et al. (1988). Polyoxygenated cyclohexane epoxide derivatives from the stem bark of Monanthotaxis buchananii. Phytochemistry,1988,27(12),3857-3860. [View] [PubMed]

No compound-protein relationship available.

SMILES: c1ccccc1C(=O)OCC23C(O3)C=CC(C2)OC(=O)c4ccccc4

Level: 2

Mol. Weight: 366.37 g/mol

SMILES: c1ccccc1C(=O)OCC23C(O3)C=CCC2

Level: 1

Mol. Weight: 366.37 g/mol

SMILES: C12C(O2)CC(C=C1)OC(=O)c3ccccc3

Level: 1

Mol. Weight: 366.37 g/mol

SMILES: C12C(O2)CCC=C1

Level: 0

Mol. Weight: 366.37 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 366.37 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.92
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.46
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -3.18

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.82
Plasma Protein Binding: 52.7
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 8.92
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.98
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.55
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.43
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -15.46
Rat (Acute): 2.89
Rat (Chronic Oral): 2.28
Fathead Minnow: 4.57
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 399.22
Hydration Free Energy: -5.96
Log(D) at pH=7.4: 2.58
Log(P): 3.03
Log S: -4.49
Log(Vapor Pressure): -7.83
Melting Point: 104.0
pKa Acid: 6.41
pKa Basic: -3.29

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.9604
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.9604
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9339
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9339
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9322
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9322
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9104
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.9104
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8956
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8956
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8849
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8849
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8758
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8758
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8674
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8674
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8645
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8645
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.8355
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	3	0.8355
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.8349
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.8349
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8325
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8325
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8287
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8287
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.8270
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.8270
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8254
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8254
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8227
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8227
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8156
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8156
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.8141
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.8141
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8131
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8131
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.8107
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.8107
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8101
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8101
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8096
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.8096
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.8048
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.8048
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7997
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7997
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7990
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7990
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7981
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7981
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7955
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7955
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7858
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7858
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7820
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7820
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7799
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7799
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.7792
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.7792
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7757
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7757
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7723
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	2	0.7723
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7722
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7722
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	3	0.7714
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	3	0.7714
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	2	0.7666
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	2	0.7666
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7665
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7665
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	2	0.7648
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	2	0.7648
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7618
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7618
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7617
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7617
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7616
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7616
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7612
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7612
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7603
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7603
Heat shock cognate 71 kDa protein	P11142	HSP7C_HUMAN	Homo sapiens	3	0.7587
Heat shock cognate 71 kDa protein	P11142	HSP7C_HUMAN	Homo sapiens	3	0.7587
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7547
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7547
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7539
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7539
Tryptase alpha/beta-1	Q15661	TRYB1_HUMAN	Homo sapiens	3	0.7513
Tryptase alpha/beta-1	Q15661	TRYB1_HUMAN	Homo sapiens	3	0.7513
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7499
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7499
Tyrosine-protein phosphatase non-receptor type 18	Q99952	PTN18_HUMAN	Homo sapiens	4	0.7495
Tyrosine-protein phosphatase non-receptor type 18	Q99952	PTN18_HUMAN	Homo sapiens	4	0.7495
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7480
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7480
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7480
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7480
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7480
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7480
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7475
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7475
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7457
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7457
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7443
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7443
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7443
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7443
Genome polyprotein	Q99AU2	Q99AU2_9HEPC	Hepatitis C virus subtype 1b	3	0.7442
Genome polyprotein	Q99AU2	Q99AU2_9HEPC	Hepatitis C virus subtype 1b	3	0.7442
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7430
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7430
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7424
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7424
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7423
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7423
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7399
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7399
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7396
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7396
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7389
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7389
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7379
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7379
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7369
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7369
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7363
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7363
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7339
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7339
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7332
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7332
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7315
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7315
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7314
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7314
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7296
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	3	0.7296
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7282
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7282
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7277
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7277
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7275
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7275
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	2	0.7266
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	2	0.7266
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7262
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7262
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7260
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7260
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7256
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7256
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7252
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7252
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7250
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7250
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	2	0.7248
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	2	0.7248
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7239
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7239
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7212
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7212
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7194
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7194
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7192
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7192
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7188
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7188
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7187
Inosine-5'-monophosphate dehydrogenase	P50097	IMDH_TRIFO	Tritrichomonas foetus	2	0.7187
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7183
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7183
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7181
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7181
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7178
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7178
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7177
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7177
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7154
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7154
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7153
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7153
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	2	0.7149
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	2	0.7149
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7144
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7144
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7142
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7142
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7138
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7138
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7127
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7127
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7118
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7118
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7115
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7115
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7111
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7111
UDP-N-acetylenolpyruvoylglucosamine reductase	P08373	MURB_ECOLI	Escherichia coli	3	0.7103
UDP-N-acetylenolpyruvoylglucosamine reductase	P08373	MURB_ECOLI	Escherichia coli	3	0.7103
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.7101
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.7101
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7094
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7094
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7091
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7091
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7090
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7090
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7087
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7087
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7079
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7079
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7072
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7072
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7066
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7066
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7055
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7055
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7051
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7051
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7040
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7040
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7029
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7029
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7028
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7028
Phosphoribosylformylglycinamidine synthase subunit PurL	Q9X0X3	PURL_THEMA	Thermotoga maritima	3	0.7018
Phosphoribosylformylglycinamidine synthase subunit PurL	Q9X0X3	PURL_THEMA	Thermotoga maritima	3	0.7018
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7015
Acidic phospholipase A2 3	P60045	PA2A3_NAJSG	Naja sagittifera	2	0.7015

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