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Schweinfurthin A

Family: Animalia - Apidae
Kingdom: Animalia
Class: Phenolic
- Subclass: Lignan

Canonical Smiles	C/C(=C\Cc1c(O)cc(cc1O)/C=C/c1cc(O)c2c(c1)C[C@H]1[C@@](O2)(C)C[C@H]([C@H](C1(C)C)O)O)/CCC=C(C)C
InChI	InChI=1S/C34H44O6/c1-20(2)8-7-9-21(3)10-13-25-26(35)15-23(16-27(25)36)12-11-22-14-24-18-30-33(4,5)32(39)29(38)19-34(30,6)40-31(24)28(37)17-22/h8,10-12,14-17,29-30,32,35-39H,7,9,13,18-19H2,1-6H3/b12-11+,21-10+/t29-,30-,32-,34-/m1/s1
InChIKey	HSDZWMOBUPRZEU-LXYWBZBZSA-N
Formula	C₃₄H₄₄O₆
HBA	6
HBD	5
MW	548.72
Rotatable Bonds	7
TPSA	110.38
LogP	6.67
Number Rings	4
Number Aromatic Rings	2
Heavy Atom Count	40
Formal Charge	0
Fraction CSP3	0.47
Exact Mass	548.31
Number of Lipinski Rule Violations	2

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Apis species	Apidae	Animalia	7459

Showing of synonyms

Petrova A, Popova M, et al. (2010). New biologically active compounds from Kenyan propolis.. Fitoterapia,2010,81(6),509-514. [View] [PubMed]

Pubchem: 643462

Cas: 217476-92-1

Zinc: ZINC000028820045

Nmrshiftdb2: 20036954

Chembl: CHEMBL232644

Comptox: DTXSID80349186

CPRiL: 103890

SMILES: c1ccccc1C=Cc(c2)ccc(c23)OC4C(C3)CCCC4

Level: 1

Mol. Weight: 548.72 g/mol

SMILES: c1cccc(c12)OC3C(C2)CCCC3

Level: 0

Mol. Weight: 548.72 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 548.72 g/mol

Antibacterial

Absorption

Caco-2 (logPapp): -5.43
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.03
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -0.7

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.04
Plasma Protein Binding: 98.9
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Inhibitor
OATP1B3: Inhibitor

Excretion

Clearance: 9.49
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.51
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.05
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.95
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -1964.82
Rat (Acute): 2.09
Rat (Chronic Oral): 3.06
Fathead Minnow: 11.97
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Toxic
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 528.92
Hydration Free Energy: -3.04
Log(D) at pH=7.4: 4.89
Log(P): 7.91
Log S: -6.22
Log(Vapor Pressure): -9.85
Melting Point: 202.66
pKa Acid: 8.65
pKa Basic: 6.83

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9740
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9740
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.9390
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.9390
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.9210
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.9210
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.9012
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.9012
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8921
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8921
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8860
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8860
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8853
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8853
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8841
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8841
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8807
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8807
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.8793
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.8793
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.8730
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.8730
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.8720
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.8720
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8697
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8697
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8631
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8631
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.8580
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.8580
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8565
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8565
Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CP17A_HUMAN	Homo sapiens	3	0.8563
Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CP17A_HUMAN	Homo sapiens	3	0.8563
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8484
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8484
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.8451
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.8451
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8419
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8419
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.8415
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.8415
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.8390
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.8390
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.8360
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.8360
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.8355
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.8355
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8350
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8350
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8327
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8327
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8322
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8322
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.8281
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.8281
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8277
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8277
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8236
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8236
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8190
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.8190
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.8178
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.8178
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	3	0.8159
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	3	0.8159
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8156
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8156
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.8138
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.8138
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8106
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8106
Bacteriorhodopsin	P02945	BACR_HALSA	Halobacterium salinarum	3	0.8099
Bacteriorhodopsin	P02945	BACR_HALSA	Halobacterium salinarum	3	0.8099
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8090
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8090
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.8086
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.8086
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8062
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8062
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8011
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8011
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.7947
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.7947
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7937
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7937
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7930
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7930
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	3	0.7925
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	3	0.7925
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7919
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7919
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7893
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7893
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7892
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7892
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7891
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7891
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7864
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7864
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7851
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7851
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7844
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7844
Probable esterase KAI2	Q9SZU7	KAI2_ARATH	Arabidopsis thaliana	3	0.7808
Probable esterase KAI2	Q9SZU7	KAI2_ARATH	Arabidopsis thaliana	3	0.7808
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7804
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7804
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7769
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7769
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7757
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7757
Vitamin D(3) 25-hydroxylase	C4B644	CPVDH_PSEAH	Pseudonocardia autotrophica	3	0.7755
Vitamin D(3) 25-hydroxylase	C4B644	CPVDH_PSEAH	Pseudonocardia autotrophica	3	0.7755
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7729
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7729
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.7705
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.7705
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.7670
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.7670
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.7664
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.7664
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	3	0.7654
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	3	0.7654
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7614
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7614
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7608
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7608
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	3	0.7567
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	3	0.7567
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7557
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7557
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7551
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7551
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	3	0.7518
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	3	0.7518
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7514
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7514
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7507
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7507
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7495
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7495
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.7475
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.7475
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7469
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7469
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.7454
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.7454
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7445
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7445
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7414
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7414
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7398
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7398
3',5'-cyclic-AMP phosphodiesterase 4A	P27815	PDE4A_HUMAN	Homo sapiens	3	0.7396
3',5'-cyclic-AMP phosphodiesterase 4A	P27815	PDE4A_HUMAN	Homo sapiens	3	0.7396
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7373
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7373
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7330
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7330
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7326
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7326
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7302
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7302
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7298
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7298
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7280
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7280
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	5	0.7279
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	5	0.7279
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.7276
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.7276
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7272
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7272
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7262
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7262
Beta-elicitin cryptogein	P15570	ELIB_PHYCR	Phytophthora cryptogea	3	0.7258
Beta-elicitin cryptogein	P15570	ELIB_PHYCR	Phytophthora cryptogea	3	0.7258
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7254
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7254
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7250
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7250
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7238
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7238
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7223
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7223
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7179
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7179
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7178
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7178
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7164
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7164
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7160
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7160
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7158
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7158
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7135
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7135
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7134
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7134
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7113
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7113
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.7111
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.7111
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7105
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7105
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7096
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7096
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7083
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7083
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7072
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7072
Corticosteroid-binding globulin	P31211	CBG_RAT	Rattus norvegicus	3	0.7048
Corticosteroid-binding globulin	P31211	CBG_RAT	Rattus norvegicus	3	0.7048
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.7025
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.7025
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7025
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7025
Kinesin heavy chain	Q41460	Q41460_SOLTU	Solanum tuberosum	3	0.7024
Kinesin heavy chain	Q41460	Q41460_SOLTU	Solanum tuberosum	3	0.7024
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7010
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7010
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7002
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7002

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