8-hydroxy-6-methylxanthone-1-carboxylic acid - Compound Card

8-hydroxy-6-methylxanthone-1-carboxylic acid

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8-hydroxy-6-methylxanthone-1-carboxylic acid

Structure
Zoomed Structure
  • Family: Plantae - Asphodelaceae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles Cc1cc(O)c2c(c1)oc1c(c2=O)c(ccc1)C(=O)O
InChI InChI=1S/C15H10O5/c1-7-5-9(16)13-11(6-7)20-10-4-2-3-8(15(18)19)12(10)14(13)17/h2-6,16H,1H3,(H,18,19)
InChIKey PDFFNVIOJNUWTC-UHFFFAOYSA-N
Formula C15H10O5
HBA 4
HBD 2
MW 270.24
Rotatable Bonds 1
TPSA 87.74
LogP 2.66
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.07
Exact Mass 270.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Bulbine frutescens Asphodelaceae Plantae 210954

Showing of synonyms

  • Abdissa N, Heydenreich M, et al. (2014). A xanthone and a phenylanthraquinone from the roots of Bulbine frutescens, and the revision of six seco-anthraquinones into xanthones. Phytochemistry Letters,2014,9,67-73. [View] [PubMed]
Pubchem: 71391887

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 270.24 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-4.73
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.01
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.71

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.48
Plasma Protein Binding
71.82
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.31
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.35
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.38
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.04
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
5.58
Rat (Acute)
1.91
Rat (Chronic Oral)
3.11
Fathead Minnow
3.92
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
453.11
Hydration Free Energy
-7.58
Log(D) at pH=7.4
0.58
Log(P)
3.6
Log S
-2.97
Log(Vapor Pressure)
-7.92
Melting Point
238.95
pKa Acid
7.1
pKa Basic
4.49
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9775
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9775
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9306
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9306
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.9101
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.9101
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9031
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9031
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8920
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8920
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8873
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8873
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8798
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8798
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8782
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8782
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8766
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8766
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.8745
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.8745
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.8641
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.8641
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8608
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8608
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8591
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8591
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8517
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8517
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.8500
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.8500
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8473
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8473
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8404
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8404
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8399
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8399
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8389
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8389
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8351
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8351
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.8308
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.8308
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8305
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8305
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.8281
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.8281
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.8278
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.8278
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8218
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8218
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8215
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8215
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8203
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8203
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8203
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8203
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 4 0.8145
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 4 0.8145
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8142
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8142
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8129
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8129
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8089
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8089
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8085
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8085
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8073
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8073
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8063
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8063
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 3 0.8032
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 3 0.8032
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7999
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7999
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7967
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7967
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7957
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7957
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7946
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7946
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7924
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7924
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7898
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7898
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7858
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7858
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7853
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7853
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.7844
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.7844
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7838
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7838
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7821
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7821
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7789
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7789
Stimulator of interferon genes protein Q3TBT3 STING_MOUSE Mus musculus 3 0.7783
Stimulator of interferon genes protein Q3TBT3 STING_MOUSE Mus musculus 3 0.7783
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7761
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7761
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7754
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7754
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7742
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7742
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 3 0.7717
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 3 0.7717
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7650
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7650
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7631
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7631
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7625
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7625
Tyrosine-protein kinase Lyn P25911 LYN_MOUSE Mus musculus 3 0.7620
Tyrosine-protein kinase Lyn P25911 LYN_MOUSE Mus musculus 3 0.7620
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7610
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7610
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7574
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7574
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7532
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7532
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7526
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7526
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 4 0.7492
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 4 0.7492
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7459
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7459
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7411
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7411
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7409
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7409
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.7408
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.7408
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7397
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7397
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7393
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7393
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7348
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7348
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7327
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7327
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7316
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7316
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7306
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7306
Carbonic anhydrase 13 Q8N1Q1 CAH13_HUMAN Homo sapiens 3 0.7300
Carbonic anhydrase 13 Q8N1Q1 CAH13_HUMAN Homo sapiens 3 0.7300
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7294
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7294
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7287
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7287
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7286
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7286
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7263
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7263
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7260
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7260
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7248
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7248
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 3 0.7238
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 3 0.7238
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 3 0.7200
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 3 0.7200
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7183
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7183
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7164
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7164
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7144
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7144
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7121
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7121
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7112
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7112
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7105
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7105
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7104
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7104
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7090
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7090
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7077
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7077
Fatty acid synthase P49327 FAS_HUMAN Homo sapiens 3 0.7062
Fatty acid synthase P49327 FAS_HUMAN Homo sapiens 3 0.7062
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7056
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7056
Beta-1,4-galactosyltransferase 1 P08037 B4GT1_BOVIN Bos taurus 3 0.7053
Beta-1,4-galactosyltransferase 1 P08037 B4GT1_BOVIN Bos taurus 3 0.7053
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7049
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7049
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 2 0.7041
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 2 0.7041
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7038
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7038
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7035
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7035
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7021
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7021
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7016
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7016
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7006
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7006

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