Janthinone - Compound Card

Janthinone

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Janthinone

Structure
Zoomed Structure
  • Family: Asphodelaceae
  • Kingdom: Plantae
  • Class: Quinone
    • Subclass: Anthraquinone
Canonical Smiles COc1cccc2c1c(=O)c1c(O)cc(cc1oc2=O)C
InChI InChI=1S/C16H12O5/c1-8-6-10(17)14-12(7-8)21-16(19)9-4-3-5-11(20-2)13(9)15(14)18/h3-7,17H,1-2H3
InChIKey ZCPWKZUDPGMFMG-UHFFFAOYSA-N
Formula C16H12O5
HBA 5
HBD 1
MW 284.27
Rotatable Bonds 1
TPSA 76.74
LogP 2.33
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 284.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Bulbine frutescens Asphodelaceae Plantae 210954

Showing of synonyms

  • Abdissa N, Heydenreich M, et al. (2014). A xanthone and a phenylanthraquinone from the roots of Bulbine frutescens, and the revision of six seco-anthraquinones into xanthones. Phytochemistry Letters,2014,9,67-73. [View] [PubMed]
Pubchem: 11231432
Nmrshiftdb2: 70112297

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)c(=O)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 224.22 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-4.66
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.420
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.47

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.470
Plasma Protein Binding
77.26
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.970
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.240
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.200
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.750
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.310
Rat (Acute)
2.110
Rat (Chronic Oral)
2.090
Fathead Minnow
4.770
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
436.720
Hydration Free Energy
-10.390
Log(D) at pH=7.4
2.410
Log(P)
3.02
Log S
-5.38
Log(Vapor Pressure)
-7.44
Melting Point
209.68
pKa Acid
6.97
pKa Basic
3.51
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9352
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9352
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.9113
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.9113
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9055
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9055
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9037
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9037
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8988
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8988
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8834
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8834
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.8747
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.8747
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8676
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8676
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8577
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8577
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8520
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8520
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8339
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8339
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8270
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8270
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8202
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8202
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8142
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8142
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.8136
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.8136
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8075
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8075
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8048
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8048
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8000
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8000
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7992
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7992
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7978
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7978
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7976
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7976
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7966
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7966
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7957
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7957
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7937
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7937
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 4 0.7891
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 4 0.7891
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7889
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7889
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7859
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7859
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7847
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7847
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7831
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7831
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7812
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7812
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7812
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7812
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7807
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7807
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7760
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7760
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7710
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7710
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7677
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7677
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7643
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7643
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7641
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7641
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7636
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7636
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7510
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7510
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7499
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7499
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7482
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7482
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7482
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7482
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7482
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7482
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7462
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7462
Tyrosine-protein kinase Lyn P25911 LYN_MOUSE Mus musculus 3 0.7455
Tyrosine-protein kinase Lyn P25911 LYN_MOUSE Mus musculus 3 0.7455
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7435
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7435
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7427
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7427
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7414
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7414
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7412
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7412
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7405
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7405
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7396
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7396
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7394
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7394
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7377
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7377
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7362
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7362
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7357
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7357
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7342
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7342
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7328
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7328
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7324
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7324
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7321
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.7321
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.7321
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7321
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7302
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7302
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7298
Fructose-1,6-bisphosphatase 1 P00636 F16P1_PIG Sus scrofa 3 0.7298
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7298
Fructose-1,6-bisphosphatase 1 P00636 F16P1_PIG Sus scrofa 3 0.7298
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7294
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7294
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7285
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7285
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7281
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7281
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7261
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7261
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7258
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7258
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7252
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7252
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7249
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7249
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7241
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7241
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7241
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7241
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7235
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7235
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7225
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7225
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7224
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7224
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7218
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7218
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 5 0.7205
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 5 0.7205
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7204
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7204
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7202
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7202
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7197
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7197
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7192
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7192
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7176
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7176
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7172
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7172
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7170
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7170
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7167
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7167
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7162
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7162
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7153
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7153
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7145
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7145
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7144
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7144
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7143
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7143
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7141
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7141
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7137
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7137
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7136
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7136
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7121
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7121
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7113
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7113
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7112
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7112
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7108
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7108
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7104
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7104
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7091
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7091
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7084
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7084
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7076
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7076
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7075
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7075
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7075
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7075
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7064
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7064
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7062
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7062
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 4 0.7044
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 4 0.7044
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7041
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7041
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7040
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7040
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7040
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7040
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7037
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7037
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7021
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7021
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7014
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7014

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