1,8-dihydroxy-10-methoxy-3-methyldibenzo[b,e]oxepine-6,11-dione - Compound Card

1,8-dihydroxy-10-methoxy-3-methyldibenzo[b,e]oxepine-6,11-dione

Select a section from the left sidebar

1,8-dihydroxy-10-methoxy-3-methyldibenzo[b,e]oxepine-6,11-dione

Structure
Zoomed Structure
  • Family: Plantae - Asphodelaceae
  • Kingdom: Plantae
  • Class: Quinone
Canonical Smiles COc1cc(O)cc2c1c(=O)c1c(O)cc(cc1oc2=O)C
InChI InChI=1S/C16H12O6/c1-7-3-10(18)14-12(4-7)22-16(20)9-5-8(17)6-11(21-2)13(9)15(14)19/h3-6,17-18H,1-2H3
InChIKey VJFPLCHRWFQSPY-UHFFFAOYSA-N
Formula C16H12O6
HBA 6
HBD 2
MW 300.27
Rotatable Bonds 1
TPSA 96.97
LogP 2.03
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 300.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Bulbine frutescens Asphodelaceae Plantae 210954

Showing of synonyms

  • Abdissa N, Heydenreich M, et al. (2014). A xanthone and a phenylanthraquinone from the roots of Bulbine frutescens, and the revision of six seco-anthraquinones into xanthones. Phytochemistry Letters,2014,9,67-73. [View] [PubMed]
Pubchem: 46918631
Nmrshiftdb2: 80018053

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)c(=O)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 300.27 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-4.58
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.690
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.29

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.490
Plasma Protein Binding
75.68
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.880
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.070
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.220
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.090
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.220
Rat (Acute)
2.260
Rat (Chronic Oral)
2.430
Fathead Minnow
4.680
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
460.190
Hydration Free Energy
-9.690
Log(D) at pH=7.4
2.330
Log(P)
2.94
Log S
-5.82
Log(Vapor Pressure)
-7.75
Melting Point
264.52
pKa Acid
7.91
pKa Basic
4.51
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9355
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9355
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8974
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8974
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8964
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8964
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8866
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8866
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8821
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.8821
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8811
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8811
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8615
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8615
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8611
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8611
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8574
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8574
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8557
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8557
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8532
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8532
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8435
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8435
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8421
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8421
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8385
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8385
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.8346
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.8346
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.8316
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.8316
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8198
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8198
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8194
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8194
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8185
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8185
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8182
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8182
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.8169
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.8169
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8125
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8125
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 4 0.8120
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 4 0.8120
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8072
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8072
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.8027
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.8027
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8017
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8017
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8010
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8010
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7982
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7982
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7977
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7977
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7936
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7936
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7934
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7934
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7905
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7905
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7878
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7878
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7875
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7875
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7828
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7828
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7795
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7795
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7790
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7790
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7728
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7728
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7713
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7713
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7703
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7703
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7696
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7696
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7686
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7686
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7674
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7674
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7648
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7648
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7602
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7602
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.7559
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.7559
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7539
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7539
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7519
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7519
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7489
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7489
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7470
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7470
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7463
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7463
Alpha-2,3/2,6-sialyltransferase/sialidase Q15KI8 Q15KI8_PASMD Pasteurella multocida 4 0.7449
Alpha-2,3/2,6-sialyltransferase/sialidase Q15KI8 Q15KI8_PASMD Pasteurella multocida 4 0.7449
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7431
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7431
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7406
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7406
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7399
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7399
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7334
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7334
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7321
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7321
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7315
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7315
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7305
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7305
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7305
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7305
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7302
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7302
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7296
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7296
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7294
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7294
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7294
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7294
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7293
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7293
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7291
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7291
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7268
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7268
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7253
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7253
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7250
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7250
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7238
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7238
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7230
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7230
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7222
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7222
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7220
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7220
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7220
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7220
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7217
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7217
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7199
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7199
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7193
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7193
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7170
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7170
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7149
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7149
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7146
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7146
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7144
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7144
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7134
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7134
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7130
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7130
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7120
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7120
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7114
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7114
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7106
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7106
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7091
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7091
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7085
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7085
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7084
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7084
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7082
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7082
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.7071
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.7071
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7071
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7071
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7054
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7054
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7053
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7053
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7050
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7050
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7040
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7040
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 4 0.7039
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 4 0.7039
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7030
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7030
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 5 0.7029
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 5 0.7029
Tyrosine-protein kinase Lyn P25911 LYN_MOUSE Mus musculus 3 0.7023
Tyrosine-protein kinase Lyn P25911 LYN_MOUSE Mus musculus 3 0.7023
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7022
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7022
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7017
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7017
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7003
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7003

Download SDF