Nataloe-emodin-8-methyl ester - Compound Card

Nataloe-emodin-8-methyl ester

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Nataloe-emodin-8-methyl ester

Structure
Zoomed Structure
  • Family: Plantae - Asphodelaceae
  • Kingdom: Plantae
  • Class: Quinone
    • Subclass: Anthraquinone
Canonical Smiles COc1c(O)ccc2c1C(=O)c1c(C2=O)cc(cc1O)C
InChI InChI=1S/C16H12O5/c1-7-5-9-12(11(18)6-7)15(20)13-8(14(9)19)3-4-10(17)16(13)21-2/h3-6,17-18H,1-2H3
InChIKey OCZOZMSHTPWVFR-UHFFFAOYSA-N
Formula C16H12O5
HBA 5
HBD 2
MW 284.27
Rotatable Bonds 1
TPSA 83.83
LogP 2.19
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 284.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Aloe speciosa Asphodelaceae Plantae 1080012

Showing of synonyms

  • Dagne E. (1996). Review of the chemistry of Aloes of Africa. Bulletin of the Chemical Society of Ethiopia,1996,10(1),89-103. [View] [PubMed]
Pubchem: 10902125
Nmrshiftdb2: 60025763

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)C(=O)c3c(C2=O)cccc3

Level: 0

Mol. Weight: 284.27 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.49
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.610
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.34

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.910
Plasma Protein Binding
63.55
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.930
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.100
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.060
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.480
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.560
Rat (Acute)
2.420
Rat (Chronic Oral)
3.010
Fathead Minnow
4.400
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
419.070
Hydration Free Energy
-7.820
Log(D) at pH=7.4
2.290
Log(P)
3.28
Log S
-6.21
Log(Vapor Pressure)
-6.99
Melting Point
224.61
pKa Acid
7.62
pKa Basic
3.67
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9642
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9642
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9500
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9500
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9320
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9320
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9066
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9066
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8920
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8920
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8868
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8868
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8849
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8849
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8826
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8826
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8764
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8764
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8756
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8756
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.8618
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.8618
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8567
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8567
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8520
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8520
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8478
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8478
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8471
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8471
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8461
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8461
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8442
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8442
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8371
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8371
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8301
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8301
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8232
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8232
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8165
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8165
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8085
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8085
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8055
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8055
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8010
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8010
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7988
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7988
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7933
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7933
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7916
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7916
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7908
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7908
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7898
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7898
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7888
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7888
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7851
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7851
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7820
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7820
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7789
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7789
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7767
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7767
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7761
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7761
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7745
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7745
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7729
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7729
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7706
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7706
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7699
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7699
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7697
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7697
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7695
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7695
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7674
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7674
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7660
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7660
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7624
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7624
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7607
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7607
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7604
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7604
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7599
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7599
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7585
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7585
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7575
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7575
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7524
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7524
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7515
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7515
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7515
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7515
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7508
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7508
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7494
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7494
Fructose-1,6-bisphosphatase 1 P00636 F16P1_PIG Sus scrofa 3 0.7489
Fructose-1,6-bisphosphatase 1 P00636 F16P1_PIG Sus scrofa 3 0.7489
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7488
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7488
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7484
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7484
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7473
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7473
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7472
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7472
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7465
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7465
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7462
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7462
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7455
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7455
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 4 0.7453
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 4 0.7453
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7431
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7431
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7417
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7417
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7394
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7394
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7386
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7386
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7366
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7366
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7359
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7359
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7357
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7357
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7345
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7345
Tyrosine-protein kinase Lyn P25911 LYN_MOUSE Mus musculus 3 0.7297
Tyrosine-protein kinase Lyn P25911 LYN_MOUSE Mus musculus 3 0.7297
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7281
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7281
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7250
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7250
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7248
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7248
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7242
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7242
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7222
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7222
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7221
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7221
Bifunctional dihydrofolate reductase-thymidylate synthase Q27783 DRTS_TRYBB Trypanosoma brucei brucei 4 0.7186
Bifunctional dihydrofolate reductase-thymidylate synthase Q27783 DRTS_TRYBB Trypanosoma brucei brucei 4 0.7186
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7185
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7185
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7185
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7185
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7180
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7180
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7161
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7161
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7143
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7143
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7136
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7136
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7130
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7130
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7128
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7128
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7127
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7127
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7114
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7114
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7105
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7105
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7096
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7096
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7082
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7082
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7071
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7071
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7070
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7070
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7064
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7064
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7058
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7058
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7052
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7052
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7046
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7046
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7042
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7042
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7009
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7009

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