CA-12 (1,1-diphenylethane derivative) - Compound Card

CA-12 (1,1-diphenylethane derivative)

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CA-12 (1,1-diphenylethane derivative)

Structure
Zoomed Structure
  • Family: Plantae - Asphodelaceae
  • Kingdom: Plantae
  • Class: Benzene Derivative
Canonical Smiles Oc1ccc(cc1)C(c1c(C)cc(cc1O)O)C
InChI InChI=1S/C15H16O3/c1-9-7-13(17)8-14(18)15(9)10(2)11-3-5-12(16)6-4-11/h3-8,10,16-18H,1-2H3
InChIKey KRXSLUWZEBPRRR-UHFFFAOYSA-N
Formula C15H16O3
HBA 3
HBD 3
MW 244.29
Rotatable Bonds 2
TPSA 60.69
LogP 3.26
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.2
Exact Mass 244.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Cape aloe Asphodelaceae Plantae 25641

Showing of synonyms

  • Dagne E. (1996). Review of the chemistry of Aloes of Africa. Bulletin of the Chemical Society of Ethiopia,1996,10(1),89-103. [View] [PubMed]
Pubchem: 129686608

No compound-protein relationship available.

Structure

SMILES: c1ccccc1Cc2ccccc2

Level: 1

Mol. Weight: 244.29 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 244.29 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.79
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.670
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.99

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.720
Plasma Protein Binding
43.95
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.160
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.180
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.370
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
4.720
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
3.930
Rat (Acute)
1.950
Rat (Chronic Oral)
2.750
Fathead Minnow
4.210
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
366.570
Hydration Free Energy
-9.590
Log(D) at pH=7.4
2.890
Log(P)
2.79
Log S
-3.16
Log(Vapor Pressure)
-6.01
Melting Point
178.19
pKa Acid
9.57
pKa Basic
8.56
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9405
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9405
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9287
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9287
Bromodomain testis-specific protein Q58F21 BRDT_HUMAN Homo sapiens 3 0.9285
Bromodomain testis-specific protein Q58F21 BRDT_HUMAN Homo sapiens 3 0.9285
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.9246
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.9246
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.9172
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.9172
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9097
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9097
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.9061
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.9061
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8963
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8963
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8928
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8928
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8921
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8921
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.8903
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.8903
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8896
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8896
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8879
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8879
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8847
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.8847
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8838
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8838
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8830
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8830
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8803
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8803
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8753
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8753
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8666
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8666
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8659
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8659
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8643
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8643
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8624
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8624
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8560
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8560
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8557
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8557
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8551
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8551
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.8530
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.8530
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.8512
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.8512
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8496
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8496
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8495
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8495
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8424
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8424
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8391
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8391
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.8324
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.8324
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8304
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8304
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.8292
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.8292
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8250
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8250
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8233
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8233
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8172
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8172
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8168
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8168
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8146
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8146
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8144
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8144
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8100
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8100
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.8064
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.8064
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8057
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8057
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8030
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8030
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8021
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8021
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8005
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 4 0.8005
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 4 0.8005
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8005
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7963
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7963
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7958
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7958
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7946
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7946
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7909
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7909
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7908
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7908
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 3 0.7893
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 3 0.7893
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7880
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7880
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7839
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7839
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7823
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7823
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7764
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7764
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7756
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7756
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7754
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7754
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7745
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7745
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7732
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7732
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7722
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7722
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7649
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7649
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7645
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7645
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7640
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7640
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7639
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7639
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7637
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7637
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7611
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7611
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7594
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7594
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7572
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7572
Pyruvate dehydrogenase E1 component P0AFG8 ODP1_ECOLI Escherichia coli 3 0.7570
Pyruvate dehydrogenase E1 component P0AFG8 ODP1_ECOLI Escherichia coli 3 0.7570
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7569
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7569
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7563
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7563
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7559
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7559
Phytohormone-binding protein G7J032 PHBP_MEDTR Medicago truncatula 4 0.7554
Phytohormone-binding protein G7J032 PHBP_MEDTR Medicago truncatula 4 0.7554
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7553
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7553
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7545
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7545
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7538
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7538
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7516
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7516
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7515
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7515
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7514
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7514
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7484
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7484
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7466
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7466
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7466
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7466
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7461
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7461
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7456
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7456
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7447
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7447
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7442
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7442
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7425
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7425
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7419
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7419
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7396
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7396
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7394
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7394
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7393
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7393
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7381
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7381
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7377
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7377
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7377
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7377
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 4 0.7375
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 4 0.7375
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7374
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7374
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7372
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7372
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7367
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7367
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7364
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7364
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7359
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7359
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7356
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7356
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7355
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7355
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7351
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7351
Thyroxine-binding globulin P05543 THBG_HUMAN Homo sapiens 3 0.7349
Thyroxine-binding globulin P05543 THBG_HUMAN Homo sapiens 3 0.7349
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7348
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7348
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7341
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7341
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7341
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7341
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7339
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7339
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7333
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.7333
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7326
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7326
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7320
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7320
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7317
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7317
N(2)-(2-carboxyethyl)arginine synthase Q9LCV9 CEAS_STRCL Streptomyces clavuligerus 3 0.7315
N(2)-(2-carboxyethyl)arginine synthase Q9LCV9 CEAS_STRCL Streptomyces clavuligerus 3 0.7315
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7309
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7309
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7308
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7308
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7298
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7298
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.7295
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.7295
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7290
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7290
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 3 0.7284
Transketolase 1 P23254 TKT1_YEAST Saccharomyces cerevisiae 3 0.7284
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7273
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7273
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7264
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7264
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7250
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7250
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7248
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7248
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7245
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7245
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7244
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7244
Pyruvate decarboxylase isozyme 1 P06169 PDC1_YEAST Saccharomyces cerevisiae 3 0.7236
Pyruvate decarboxylase isozyme 1 P06169 PDC1_YEAST Saccharomyces cerevisiae 3 0.7236
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7234
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7234
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7224
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7224
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7221
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7221
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7211
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7211
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7202
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7202
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7199
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7199
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7197
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7197
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7196
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7196
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7190
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7190
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7187
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7187
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7184
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7184
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7177
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7177
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7177
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7177
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7170
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7170
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7161
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7161
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7160
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7160
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7159
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7159
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7152
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7152
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7148
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 4 0.7148
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7148
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 4 0.7148
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7138
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7138
Abscisic acid receptor PYL10 Q8H1R0 PYL10_ARATH Arabidopsis thaliana 3 0.7127
Abscisic acid receptor PYL10 Q8H1R0 PYL10_ARATH Arabidopsis thaliana 3 0.7127
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 4 0.7125
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 4 0.7125
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7119
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7119
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7113
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7113
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7108
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7108
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7104
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7104
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7101
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7101
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7099
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7099
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.7098
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.7098
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7093
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7093
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7091
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7091
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 3 0.7085
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 3 0.7085
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7083
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7083
transketolase Q2SZA7 Q2SZA7_BURTA Burkholderia thailandensis 3 0.7078
transketolase Q2SZA7 Q2SZA7_BURTA Burkholderia thailandensis 3 0.7078
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7077
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7077
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7075
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7075
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7075
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7075
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7072
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7072
Albumin P02768 ALBU_HUMAN Homo sapiens 4 0.7066
Albumin P02768 ALBU_HUMAN Homo sapiens 4 0.7066
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7063
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7063
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7055
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7055
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7047
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7047
Transketolase 1 P27302 TKT1_ECOLI Escherichia coli 3 0.7038
Transketolase 1 P27302 TKT1_ECOLI Escherichia coli 3 0.7038
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7036
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7036
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7028
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7028
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7014
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7014

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