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Furoaloesone

Family: Plantae - Asphodelaceae
Kingdom: Plantae
Class: Chromone

Canonical Smiles	CC(=O)Cc1cc(=O)c2c(o1)c1ccoc1cc2C
InChI	InChI=1S/C15H12O4/c1-8-5-13-11(3-4-18-13)15-14(8)12(17)7-10(19-15)6-9(2)16/h3-5,7H,6H2,1-2H3
InChIKey	DKEVPQSVGDIHJO-UHFFFAOYSA-N
Formula	C₁₅H₁₂O₄
HBA	4
HBD	0
MW	256.26
Rotatable Bonds	2
TPSA	60.42
LogP	2.98
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	19
Formal Charge	0
Fraction CSP3	0.2
Exact Mass	256.07
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Cape aloe	Asphodelaceae	Plantae	25641

Showing of synonyms

Dagne E. (1996). Review of the chemistry of Aloes of Africa. Bulletin of the Chemical Society of Ethiopia,1996,10(1),89-103. [View] [PubMed]

Pubchem: 639278

Zinc: ZINC000015222035

Nmrshiftdb2: 10018975

No compound-protein relationship available.

SMILES: c1coc(c12)ccc3c2occc3=O

Level: 0

Mol. Weight: 256.26 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.7
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.47
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.73

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.5
Plasma Protein Binding: 61.8
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.44
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.36
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.22
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 3.9
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 4.03
Rat (Acute): 2.41
Rat (Chronic Oral): 2.07
Fathead Minnow: 4.72
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 417.91
Hydration Free Energy: -11.11
Log(D) at pH=7.4: 2.23
Log(P): 1.98
Log S: -2.29
Log(Vapor Pressure): -6.51
Melting Point: 186.26
pKa Acid: 5.1
pKa Basic: 5.1

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.9769
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.9769
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.9649
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.9649
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9620
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9620
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9597
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9597
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9562
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9562
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9492
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9492
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9460
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9460
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9460
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9460
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9456
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9456
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	3	0.9448
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	3	0.9448
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.9274
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.9274
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	3	0.9234
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	3	0.9234
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.9186
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.9186
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9112
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9112
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9039
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9039
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.9031
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.9031
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.9021
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.9021
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8978
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8978
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8968
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8968
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8940
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8940
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8926
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8926
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.8902
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.8902
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8864
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8864
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8861
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8861
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	3	0.8843
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	3	0.8843
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.8842
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.8842
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8810
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8810
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8690
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8690
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8669
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8669
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8627
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8627
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8610
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8610
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8551
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8551
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8548
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8548
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.8513
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.8513
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8508
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8508
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8489
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.8489
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8456
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8456
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8436
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8436
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	3	0.8377
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	3	0.8377
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.8374
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q04631	FNTA_RAT	Rattus norvegicus	3	0.8374
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.8336
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.8336
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8289
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8289
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.8251
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.8251
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8218
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8218
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	4	0.8189
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	4	0.8189
Beta-2 adrenergic receptor	P07550	ADRB2_HUMAN	Homo sapiens	3	0.8105
Beta-2 adrenergic receptor	P07550	ADRB2_HUMAN	Homo sapiens	3	0.8105
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8049
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8049
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8017
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8017
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.8017
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.8017
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	3	0.8000
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	3	0.8000
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7993
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7993
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	3	0.7926
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	3	0.7926
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7880
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7880
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7872
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7872
Caspase-7	P55210	CASP7_HUMAN	Homo sapiens	3	0.7855
Caspase-7	P55210	CASP7_HUMAN	Homo sapiens	3	0.7855
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7831
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7831
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7799
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7799
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7778
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7778
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7769
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7769
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7736
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7736
Dual specificity protein kinase TTK	P33981	TTK_HUMAN	Homo sapiens	3	0.7711
Dual specificity protein kinase TTK	P33981	TTK_HUMAN	Homo sapiens	3	0.7711
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7710
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7710
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7685
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7685
Cytochrome P450 11B2, mitochondrial	P19099	C11B2_HUMAN	Homo sapiens	4	0.7685
Cytochrome P450 11B2, mitochondrial	P19099	C11B2_HUMAN	Homo sapiens	4	0.7685
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7669
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7669
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7648
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7648
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7639
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7639
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7632
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7632
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7625
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7625
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.7618
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.7618
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7617
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7617
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7613
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7613
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7609
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7609
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	2	0.7591
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	2	0.7591
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7589
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7589
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7583
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7583
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7581
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7581
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.7579
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.7579
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7563
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7563
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7558
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	3	0.7558
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7558
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase	Q84HC8	NCSB1_STRCZ	Streptomyces carzinostaticus	3	0.7558
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7553
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7553
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7529
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.7529
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7527
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7527
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7522
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7522
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7494
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7494
17-beta-hydroxysteroid dehydrogenase 14	Q9BPX1	DHB14_HUMAN	Homo sapiens	2	0.7470
17-beta-hydroxysteroid dehydrogenase 14	Q9BPX1	DHB14_HUMAN	Homo sapiens	2	0.7470
Orotidine 5'-phosphate decarboxylase	O26232	PYRF_METTH	Methanothermobacter thermautotrophicus	3	0.7455
Orotidine 5'-phosphate decarboxylase	O26232	PYRF_METTH	Methanothermobacter thermautotrophicus	3	0.7455
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	2	0.7437
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	2	0.7437
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7429
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7429
Odorant-binding protein	P81245	OBP_PIG	Sus scrofa	3	0.7425
Odorant-binding protein	P81245	OBP_PIG	Sus scrofa	3	0.7425
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7424
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7424
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7421
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7421
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7419
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7419
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7397
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7397
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7383
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7383
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7383
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7383
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7368
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7368
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7363
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7363
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7352
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7352
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7349
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7349
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7348
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	2	0.7348
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7338
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7338
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.7337
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	3	0.7337
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7334
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7334
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	3	0.7334
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	3	0.7334
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7309
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7309
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7308
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	3	0.7308
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7308
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	3	0.7308
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7305
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7305
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7304
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7304
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7289
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7289
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7280
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7280
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7269
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7269
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7260
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	3	0.7260
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7246
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7246
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7243
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7243
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7235
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7235
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7230
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7230
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7224
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7224
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7218
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7218
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7209
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7209
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	3	0.7208
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	3	0.7208
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7199
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7199
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7195
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7195
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	2	0.7184
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	2	0.7184
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7183
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7183
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.7172
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.7172
Protoporphyrinogen oxidase, mitochondrial	O24164	PPOM_TOBAC	Nicotiana tabacum	2	0.7167
Protoporphyrinogen oxidase, mitochondrial	O24164	PPOM_TOBAC	Nicotiana tabacum	2	0.7167
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7166
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7166
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	3	0.7160
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	3	0.7160
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7158
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7158
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7154
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7154
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7150
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7150
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7145
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7145
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7144
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7144
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7142
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7142
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7121
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7121
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	2	0.7119
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	2	0.7119
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7116
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7116
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7115
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7115
Beta-2 adrenergic receptor	P07550	ADRB2_HUMAN	Homo sapiens	2	0.7108
Beta-2 adrenergic receptor	P07550	ADRB2_HUMAN	Homo sapiens	2	0.7108
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7098
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7098
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7096
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7096
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7089
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7089
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7083
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7083
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7081
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7081
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	3	0.7080
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	3	0.7080
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7079
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7079
Catabolite activator protein	C3SQJ7	C3SQJ7_ECOLX	Escherichia coli	3	0.7057
Catabolite activator protein	C3SQJ7	C3SQJ7_ECOLX	Escherichia coli	3	0.7057
Nitroreductase domain-containing protein	Q8DW21	Q8DW21_STRMU	Streptococcus mutans serotype c	3	0.7053
Nitroreductase domain-containing protein	Q8DW21	Q8DW21_STRMU	Streptococcus mutans serotype c	3	0.7053
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7046
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7046
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7045
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7045
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7032
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7032
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7017
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7017
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7013
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7013
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7005
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7005

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