(3S,6Z)-3,7,11-trimethyl-1,6,10-dodecatrien-3-ol - Compound Card

(3S,6Z)-3,7,11-trimethyl-1,6,10-dodecatrien-3-ol

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(3S,6Z)-3,7,11-trimethyl-1,6,10-dodecatrien-3-ol

Structure
Zoomed Structure
  • Family: Plantae - Burseraceae
  • Kingdom: Plantae
  • Class: Terpenoid
    • Subclass: Sesquiterpene
Canonical Smiles C=C[C@](CC/C=C(\CCC=C(C)C)/C)(O)C
InChI InChI=1S/C15H26O/c1-6-15(5,16)12-8-11-14(4)10-7-9-13(2)3/h6,9,11,16H,1,7-8,10,12H2,2-5H3/b14-11-/t15-/m1/s1
InChIKey FQTLCLSUCSAZDY-QKXCFHHRSA-N
Formula C15H26O
HBA 1
HBD 1
MW 222.37
Rotatable Bonds 7
TPSA 20.23
LogP 4.4
Number Rings 0
Number Aromatic Rings 0
Heavy Atom Count 16
Formal Charge 0
Fraction CSP3 0.6
Exact Mass 222.2
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Commiphora quadricincta Burseraceae Plantae 2248429

Showing of synonyms

  • Assad YOH, Torto B, et al. (1997). Seasonal variation in the essential oil composition of Commiphora quadricincta and its effect on the maturation of immature adults of the desert locust, Schistocerca gregaria. Phytochemistry,1997,44(5),833-841. [View] [PubMed]
Pubchem: 5356544
Chebi: 176337
Nmrshiftdb2: 60018911
Metabolights: MTBLC176337

No compound-protein relationship available.

No scaffolds available.

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.26
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.0
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.08

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.36
Plasma Protein Binding
35.04
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.68
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.82
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.55
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
5.13
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-1.59
Rat (Acute)
1.68
Rat (Chronic Oral)
1.79
Fathead Minnow
4.38
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
261.74
Hydration Free Energy
-1.96
Log(D) at pH=7.4
3.29
Log(P)
4.78
Log S
-4.17
Log(Vapor Pressure)
-2.73
Melting Point
-1.76
pKa Acid
10.69
pKa Basic
7.11
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9624
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9624
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9479
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9479
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9397
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9397
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.9320
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.9320
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9219
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9219
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.9205
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.9205
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9147
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9147
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.9009
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.9009
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8999
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8999
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8895
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8895
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8893
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8893
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8810
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8810
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.8799
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.8799
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8768
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8768
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8737
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8737
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8705
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8705
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8634
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8634
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.8623
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.8623
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8431
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8431
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8426
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8426
Bacteriorhodopsin P02945 BACR_HALSA Halobacterium salinarum 3 0.8381
Bacteriorhodopsin P02945 BACR_HALSA Halobacterium salinarum 3 0.8381
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8374
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8374
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.8335
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.8335
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.8313
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.8313
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.8280
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.8280
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8261
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8261
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8260
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8260
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8188
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8188
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.8184
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.8184
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8170
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8170
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.8129
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.8129
Retinoic acid receptor RXR Q8T5C6 RXR_BIOGL Biomphalaria glabrata 3 0.8127
Retinoic acid receptor RXR Q8T5C6 RXR_BIOGL Biomphalaria glabrata 3 0.8127
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8063
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8063
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.8057
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.8057
Putative cytochrome P450 120 Q59990 CP120_SYNY3 Synechocystis sp 3 0.8037
Putative cytochrome P450 120 Q59990 CP120_SYNY3 Synechocystis sp 3 0.8037
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8028
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8028
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.8019
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.8019
Avidin P02701 AVID_CHICK Gallus gallus 3 0.8009
Avidin P02701 AVID_CHICK Gallus gallus 3 0.8009
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.8003
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.8003
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7996
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7996
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7996
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7996
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7985
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7985
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7983
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7983
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7980
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7980
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 3 0.7955
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 3 0.7955
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7943
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7943
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7903
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7903
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7902
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7902
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7900
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7900
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7898
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7898
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7892
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7892
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7891
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7891
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7885
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7885
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7884
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7884
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7872
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7872
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7871
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7871
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7863
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7863
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7857
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7857
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7842
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7842
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7834
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7834
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7833
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7833
Hemolymph juvenile hormone binding protein Q9U556 Q9U556_BOMMO Bombyx mori 3 0.7832
Hemolymph juvenile hormone binding protein Q9U556 Q9U556_BOMMO Bombyx mori 3 0.7832
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7831
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7831
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7828
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7828
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7820
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7820
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7801
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7801
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7801
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7801
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.7794
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.7794
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7792
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7792
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7780
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7780
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7775
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7775
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7774
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7774
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7772
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7772
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7769
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7769
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7768
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7768
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7753
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7753
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7746
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7746
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7741
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7741
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.7732
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.7732
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7732
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7732
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7730
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7730
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7721
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7721
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7714
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7714
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7714
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7714
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7710
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7710
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7708
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7708
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7703
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7703
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7702
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7702
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7691
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7691
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7668
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7668
Cartilage oligomeric matrix protein P35444 COMP_RAT Rattus norvegicus 3 0.7667
Cartilage oligomeric matrix protein P35444 COMP_RAT Rattus norvegicus 3 0.7667
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7665
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7665
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.7657
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.7657
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7651
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7651
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7627
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7627
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7620
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7620
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 4 0.7617
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7617
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 4 0.7617
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7617
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7613
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7613
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7608
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7608
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7599
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7599
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7596
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7596
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7593
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7593
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7584
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7584
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7578
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7578
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7569
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7569
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7565
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7565
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7563
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7563
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7562
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7562
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7557
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7557
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7556
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7556
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7550
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7550
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7549
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7549
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7548
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7548
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7548
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7548
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7542
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7542
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7541
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7541
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7538
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7538
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7537
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7537
Thyroid hormone receptor alpha P04625 THA_CHICK Gallus gallus 3 0.7534
Thyroid hormone receptor alpha P04625 THA_CHICK Gallus gallus 3 0.7534
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7526
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7526
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7517
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7517
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7514
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7514
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7507
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7507
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7503
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7503
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.7492
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.7492
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 2 0.7462
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 2 0.7462
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7455
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7455
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 2 0.7451
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 2 0.7451
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 2 0.7441
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 2 0.7441
Retinoic acid receptor RXR-alpha P28700 RXRA_MOUSE Mus musculus 3 0.7430
Retinoic acid receptor RXR-alpha P28700 RXRA_MOUSE Mus musculus 3 0.7430
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7429
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7429
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7421
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7421
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.7417
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.7417
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7403
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7403
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7400
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7400
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7399
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7399
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7398
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7398
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7396
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7396
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7384
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7384
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7383
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7383
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7381
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7381
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7380
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7380
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7371
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7371
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7370
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7370
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7370
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7370
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7337
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7337
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7332
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7332
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7331
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7331
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7324
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7324
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7313
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7313
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7311
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7311
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7306
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7306
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7292
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7292
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7292
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7292
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7290
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7290
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7280
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7280
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7269
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7269
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7268
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7268
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7265
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7265
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7264
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7264
Endoplasmin, putative Q8I0V4 Q8I0V4_PLAF7 Plasmodium falciparum 3 0.7252
Endoplasmin, putative Q8I0V4 Q8I0V4_PLAF7 Plasmodium falciparum 3 0.7252
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 3 0.7224
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 3 0.7224
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7208
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7208
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7200
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7200
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7186
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7186
Retinoic acid receptor beta P10826 RARB_HUMAN Homo sapiens 3 0.7167
Retinoic acid receptor beta P10826 RARB_HUMAN Homo sapiens 3 0.7167
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7147
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7147
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7140
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7140
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7137
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7137
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7134
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7134
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7133
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7133
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7129
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7129
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7125
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7125
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7119
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7119
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7118
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7118
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.7113
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.7113
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7098
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7098
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7089
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7089
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7087
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7087
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7073
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7073
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 3 0.7065
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7065
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7065
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 3 0.7065
Alanine aminotransferase Q9P9M8 Q9P9M8_9EURY Pyrococcus furiosus 2 0.7049
Alanine aminotransferase Q9P9M8 Q9P9M8_9EURY Pyrococcus furiosus 2 0.7049
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7043
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7043
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7037
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7037
Transcriptional activator protein LasR P25084 LASR_PSEAE Pseudomonas aeruginosa 3 0.7036
Transcriptional activator protein LasR P25084 LASR_PSEAE Pseudomonas aeruginosa 3 0.7036
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7033
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7033
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7029
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7029
Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily Q9XZJ5 Q9XZJ5_STRER Strongyloides stercoralis 3 0.7014
Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily Q9XZJ5 Q9XZJ5_STRER Strongyloides stercoralis 3 0.7014
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7013
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7013

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