5,4'-dihydroxy-7-dimethoxyflavanone - Compound Card

5,4'-dihydroxy-7-dimethoxyflavanone

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5,4'-dihydroxy-7-dimethoxyflavanone

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone
Canonical Smiles COC1(CC(=O)c2c(O1)cc(cc2O)OC)c1ccc(cc1)O
InChI InChI=1S/C17H16O6/c1-21-12-7-13(19)16-14(20)9-17(22-2,23-15(16)8-12)10-3-5-11(18)6-4-10/h3-8,18-19H,9H2,1-2H3
InChIKey OWCKNBNRMPQUTJ-UHFFFAOYSA-N
Formula C17H16O6
HBA 6
HBD 2
MW 316.31
Rotatable Bonds 3
TPSA 85.22
LogP 2.57
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 316.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Senecio roseiflorus Asteraceae Plantae 1886451

Showing of synonyms

  • Kerubo LO, Midiwo JO, et al. (2013). Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus. Natural Product Communications,2013,8(2),175-176. [View] [PubMed]
Pubchem: 129762930

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 316.31 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 316.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 316.31 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-4.54
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.660
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.14

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.140
Plasma Protein Binding
41.26
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.360
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.360
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.850
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.660
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.740
Rat (Acute)
2.200
Rat (Chronic Oral)
2.400
Fathead Minnow
4.500
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
408.600
Hydration Free Energy
-8.850
Log(D) at pH=7.4
2.610
Log(P)
2.73
Log S
-5.03
Log(Vapor Pressure)
-7.22
Melting Point
166.18
pKa Acid
7.57
pKa Basic
3.22
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9555
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9555
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9404
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9404
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9344
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9344
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9303
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9303
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9235
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9235
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.9208
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.9208
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9153
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9153
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9152
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9152
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9136
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9136
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9131
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9131
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9120
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9120
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9116
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9116
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8963
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8963
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8945
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8945
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8891
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8891
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8856
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8856
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8748
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8748
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8739
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8739
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8722
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8722
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8685
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8685
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8653
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8653
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8613
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8613
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8599
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8599
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8596
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8596
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8548
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8548
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8536
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8536
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8489
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8489
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8486
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8486
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8464
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8464
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8461
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8461
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8433
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8433
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8401
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8401
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8401
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8401
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8386
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8386
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8376
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8376
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8357
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8357
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8356
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8356
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8340
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8340
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8311
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8311
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8283
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8283
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8269
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8269
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8248
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8248
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8229
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8229
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8191
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8191
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8182
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8182
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8181
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8181
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8180
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8180
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8179
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8179
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8174
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8174
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8168
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8168
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8164
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8164
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8162
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8162
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8140
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8140
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8131
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8131
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8128
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8128
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8110
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8110
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8097
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8097
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8077
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8077
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8064
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8064
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8061
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8061
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8056
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8056
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8040
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8040
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.8026
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.8026
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7995
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7995
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7980
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7980
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7971
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7971
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7961
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7961
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7949
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7949
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7921
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7921
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7906
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7906
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7896
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7896
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7886
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7886
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7884
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7884
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7872
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7872
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7871
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7871
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7857
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7857
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7841
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7841
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7833
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.7833
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7830
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7830
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7788
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7788
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7767
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7767
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7757
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7757
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7730
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7730
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.7711
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.7711
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7694
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7694
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7693
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7693
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7686
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7686
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7678
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7678
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7617
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7617
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7599
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7599
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7587
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7587
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7575
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7575
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7571
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7571
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7550
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7550
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7548
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7548
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7548
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7548
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7541
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7541
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7534
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7534
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7522
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7522
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7517
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7517
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7515
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7515
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7508
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7508
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7505
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7505
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7503
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7503
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 4 0.7472
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 4 0.7472
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7459
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7459
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7453
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7453
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7451
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7451
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7450
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7450
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7428
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7428
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7409
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7409
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7407
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7407
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7404
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7404
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7393
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7393
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7388
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7388
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7387
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7387
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7379
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7379
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7374
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7374
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7364
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7364
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7363
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7363
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7352
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7352
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7351
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7351
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7330
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7330
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7329
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7329
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7327
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7327
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7324
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7324
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7322
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7322
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7317
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7317
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7303
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7303
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7300
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7300
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7299
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7299
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7290
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7290
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7283
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7283
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7281
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7281
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7276
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7276
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7274
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7274
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7247
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7247
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7243
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7243
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7235
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7235
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7235
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7235
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7212
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7212
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7207
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7207
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7198
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7198
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7194
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7194
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7192
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7192
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7184
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7184
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7171
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7171
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7168
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7168
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7168
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7168
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7160
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7160
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7160
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7160
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7156
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7156
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7144
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7144
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7140
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7140
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7140
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7140
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7138
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7138
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7126
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7126
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7125
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7125
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7123
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7123
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7119
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7119
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7108
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7108
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7094
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7094
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7094
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7094
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7093
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7093
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7089
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7089
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7087
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7087
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7083
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7083
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7078
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7078
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7077
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7077
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7069
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7069
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7067
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7067
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7066
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7066
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7065
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7065
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7064
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7064
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7058
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7058
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7049
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7049
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7040
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7040
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7040
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7040
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7017
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7017
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7011
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7011
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7002
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7002

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