5-(penta-1,3-diynyl)-2-(4-acetoxy-but-1-ynyl)-thiophene - Compound Card

5-(penta-1,3-diynyl)-2-(4-acetoxy-but-1-ynyl)-thiophene

Select a section from the left sidebar

5-(penta-1,3-diynyl)-2-(4-acetoxy-but-1-ynyl)-thiophene

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Monothiophene
Canonical Smiles CC#CC#Cc1ccc(s1)C#CCCOC(=O)C
InChI InChI=1S/C15H12O2S/c1-3-4-5-8-14-10-11-15(18-14)9-6-7-12-17-13(2)16/h10-11H,7,12H2,1-2H3
InChIKey MBXQJWYPTBOJFS-UHFFFAOYSA-N
Formula C15H12O2S
HBA 3
HBD 0
MW 256.33
Rotatable Bonds 2
TPSA 26.3
LogP 2.43
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.27
Exact Mass 256.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Escinops ellenbeckii Asteraceae Plantae —

Showing of synonyms

  • Hymete A, Rohloff J, et al. (2005). Acetylenic thiophenes from the roots of Escinops ellenbeckii from Ethiopia. Natural Product Research,2005,19(8),755-761. [View] [PubMed]
Pubchem: 14825793

No compound-protein relationship available.

Structure

SMILES: c1ccsc1

Level: 0

Mol. Weight: 256.33 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.22
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.22
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.12

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.28
Plasma Protein Binding
60.2
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.92
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.92
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Toxic
Eye Irritation
Toxic
Maximum Tolerated Dose
0.83
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.32
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
5.84
Rat (Acute)
2.27
Rat (Chronic Oral)
1.23
Fathead Minnow
4.82
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
344.61
Hydration Free Energy
-4.47
Log(D) at pH=7.4
4.19
Log(P)
4.63
Log S
-4.21
Log(Vapor Pressure)
-4.5
Melting Point
43.8
pKa Acid
8.98
pKa Basic
-0.41
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8611
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8611
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.8129
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.8129
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.8082
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.8082
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8067
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8067
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7850
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7850
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7818
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7818
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 2 0.7783
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 2 0.7783
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7716
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7716
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7715
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7715
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7709
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7709
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7707
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7707
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7701
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7701
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7699
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7699
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7689
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7689
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7683
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7683
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7673
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7673
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7640
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7640
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7623
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7623
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7616
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7616
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7604
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7604
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7602
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7602
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7602
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7602
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7589
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7589
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7588
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7588
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7575
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7575
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7569
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7569
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7565
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7565
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 2 0.7559
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 2 0.7559
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7537
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7537
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7533
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7533
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7522
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7522
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7516
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7516
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7504
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7504
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7496
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7496
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7486
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7486
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7484
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7484
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7464
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7464
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7457
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7457
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7455
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7455
Protein UshA P07024 USHA_ECOLI Escherichia coli 2 0.7454
Protein UshA P07024 USHA_ECOLI Escherichia coli 2 0.7454
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7443
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7443
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7440
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7440
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7434
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7434
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7434
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7434
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7429
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7429
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7419
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7419
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7401
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7401
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7394
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7394
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 2 0.7386
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 2 0.7386
Protein claret segregational P20480 NCD_DROME Drosophila melanogaster 2 0.7382
Protein claret segregational P20480 NCD_DROME Drosophila melanogaster 2 0.7382
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7367
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7367
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7357
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7357
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7355
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7355
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7350
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7350
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7343
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7343
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7342
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7342
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7340
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7340
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7337
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7337
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7322
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7322
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 2 0.7313
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 2 0.7313
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7310
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7310
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7305
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7305
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7304
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7304
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7303
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7303
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7302
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7302
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7296
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7296
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7279
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 2 0.7279
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 2 0.7279
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7279
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7278
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7278
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7274
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7274
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7265
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7265
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7258
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7258
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7258
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7258
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7257
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7257
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7255
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7255
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 2 0.7253
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 2 0.7253
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7250
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7250
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7249
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7249
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7242
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7242
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7240
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7240
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 2 0.7236
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 2 0.7236
Carnitine O-acetyltransferase P47934 CACP_MOUSE Mus musculus 2 0.7227
Carnitine O-acetyltransferase P47934 CACP_MOUSE Mus musculus 2 0.7227
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7226
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7226
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7222
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7222
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7221
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7221
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7218
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7218
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7203
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7203
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7201
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7201
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7199
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7199
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.7191
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.7191
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7187
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7187
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7186
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7186
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7185
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7185
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 2 0.7177
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 2 0.7177
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7168
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7168
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7167
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7167
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7164
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7164
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7164
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7164
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7164
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7164
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7162
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7162
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 2 0.7162
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 2 0.7162
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 2 0.7161
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 2 0.7161
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7159
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7159
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7152
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7152
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7144
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7144
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 2 0.7143
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 2 0.7143
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7141
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7141
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7138
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7138
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7131
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 2 0.7131
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.7131
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 2 0.7131
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7128
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7128
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7122
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7122
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7106
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7106
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7103
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7103
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 2 0.7101
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 2 0.7101
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7100
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7100
Nucleoside diphosphate kinase Q5HFV4 NDK_STAAC Staphylococcus aureus 2 0.7099
Nucleoside diphosphate kinase Q5HFV4 NDK_STAAC Staphylococcus aureus 2 0.7099
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 2 0.7099
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 2 0.7099
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7092
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7092
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.7092
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7092
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7085
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7085
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7085
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7085
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7077
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7077
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7068
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7068
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7067
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7067
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7056
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7056
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7056
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7056
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7055
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7055
mRNA cleavage and polyadenylation factor CLP1 Q08685 CLP1_YEAST Saccharomyces cerevisiae 2 0.7055
mRNA cleavage and polyadenylation factor CLP1 Q08685 CLP1_YEAST Saccharomyces cerevisiae 2 0.7055
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7052
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7052
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7049
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7049
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7047
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7047
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7046
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7046
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 2 0.7043
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 2 0.7043
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7041
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7041
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Q16875 F263_HUMAN Homo sapiens 2 0.7032
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Q16875 F263_HUMAN Homo sapiens 2 0.7032
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7029
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7029
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7016
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7016
Carboxypeptidase A1 P00730 CBPA1_BOVIN Bos taurus 2 0.7015
Carboxypeptidase A1 P00730 CBPA1_BOVIN Bos taurus 2 0.7015
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7012
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7012
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7010
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7010
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7006
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7006
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.7005
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.7005
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7003
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7003

Download SDF