5-(penta-1,3-diynyl)-2-(3-hydroxy-4-acetoxy-but-1-ynyl)-thiophene - Compound Card

5-(penta-1,3-diynyl)-2-(3-hydroxy-4-acetoxy-but-1-ynyl)-thiophene

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5-(penta-1,3-diynyl)-2-(3-hydroxy-4-acetoxy-but-1-ynyl)-thiophene

Structure
Zoomed Structure
  • Family: Plantae - Asteraceae
  • Kingdom: Plantae
  • Class: Monothiophene
Canonical Smiles CC#CC#Cc1ccc(s1)C#CC(COC(=O)C)O
InChI InChI=1S/C15H12O3S/c1-3-4-5-6-14-9-10-15(19-14)8-7-13(17)11-18-12(2)16/h9-10,13,17H,11H2,1-2H3
InChIKey GDUMYEJFTMGMBO-UHFFFAOYSA-N
Formula C15H12O3S
HBA 4
HBD 1
MW 272.32
Rotatable Bonds 2
TPSA 46.53
LogP 1.4
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.27
Exact Mass 272.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Escinops ellenbeckii Asteraceae Plantae —

Showing of synonyms

  • Hymete A, Rohloff J, et al. (2005). Acetylenic thiophenes from the roots of Escinops ellenbeckii from Ethiopia. Natural Product Research,2005,19(8),755-761. [View] [PubMed]
Pubchem: 14550070

No compound-protein relationship available.

Structure

SMILES: c1ccsc1

Level: 0

Mol. Weight: 272.32 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.19
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.15
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.21

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.15
Plasma Protein Binding
48.68
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.73
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.51
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.75
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.75
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
5.54
Rat (Acute)
2.59
Rat (Chronic Oral)
1.35
Fathead Minnow
4.74
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
351.53
Hydration Free Energy
-7.84
Log(D) at pH=7.4
3.15
Log(P)
3.5
Log S
-3.34
Log(Vapor Pressure)
-5.63
Melting Point
72.2
pKa Acid
8.79
pKa Basic
-0.84
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9694
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9694
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9384
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9384
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9185
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.9185
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.9165
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.9165
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.9055
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.9055
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9005
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.9005
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.9001
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.9001
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.8950
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 3 0.8950
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.8899
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.8899
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.8867
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.8867
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8811
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8811
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8748
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8748
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8726
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8726
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8678
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8678
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.8655
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.8655
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8605
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8605
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8600
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8600
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8598
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8598
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8543
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8543
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8491
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8491
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.8393
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.8393
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8324
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8324
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 3 0.8267
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 3 0.8267
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8253
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8253
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8150
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8150
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 4 0.8133
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 4 0.8133
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8091
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8091
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8087
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8087
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8067
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8067
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.8059
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.8059
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7906
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7906
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7849
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7849
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7784
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7784
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7760
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7760
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7738
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7738
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7699
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7699
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7696
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7696
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 2 0.7689
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 2 0.7689
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7677
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7677
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7643
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7643
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7629
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7629
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7588
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7588
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7588
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7588
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7578
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7578
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7575
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7575
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7553
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7553
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7493
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7493
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7493
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7493
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7493
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.7493
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7478
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7478
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7457
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7457
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7424
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7424
Regulatory protein SdiA P07026 SDIA_ECOLI Escherichia coli 3 0.7410
Regulatory protein SdiA P07026 SDIA_ECOLI Escherichia coli 3 0.7410
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7407
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7407
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7406
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7406
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7395
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7395
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7384
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7384
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7383
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7383
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7378
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7378
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7373
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7373
Pyridine nucleotide-disulfide oxidoreductase, class I A0A6L7H7X4 A0A0F7RMY2_BACAN Bacillus anthracis 3 0.7372
Pyridine nucleotide-disulfide oxidoreductase, class I A0A6L7H7X4 A0A0F7RMY2_BACAN Bacillus anthracis 3 0.7372
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7370
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7370
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7368
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7368
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7342
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7342
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7339
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7339
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7331
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7331
cAMP-dependent protein kinase regulatory subunit P07278 KAPR_YEAST Saccharomyces cerevisiae 3 0.7330
cAMP-dependent protein kinase regulatory subunit P07278 KAPR_YEAST Saccharomyces cerevisiae 3 0.7330
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7328
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7328
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7326
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7326
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7308
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7308
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7299
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7299
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7294
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7294
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7283
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7283
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7282
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7282
Aminopeptidase A2V759 A2V759_9BACL Aneurinibacillus sp. AM-1 3 0.7280
Aminopeptidase A2V759 A2V759_9BACL Aneurinibacillus sp. AM-1 3 0.7280
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7279
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7279
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7278
Protein claret segregational P20480 NCD_DROME Drosophila melanogaster 2 0.7278
Protein claret segregational P20480 NCD_DROME Drosophila melanogaster 2 0.7278
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7278
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7256
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7256
Metallophosphoesterase MPPED2 B1WBP0 MPPD2_RAT Rattus norvegicus 3 0.7254
Metallophosphoesterase MPPED2 B1WBP0 MPPD2_RAT Rattus norvegicus 3 0.7254
Adenosine 5'-monophosphoramidase HINT1 P80912 HINT1_RABIT Oryctolagus cuniculus 3 0.7247
Adenosine 5'-monophosphoramidase HINT1 P80912 HINT1_RABIT Oryctolagus cuniculus 3 0.7247
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7238
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7238
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7233
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7233
Tyrosine-protein kinase receptor TYRO3 P55144 TYRO3_MOUSE Mus musculus 3 0.7229
Tyrosine-protein kinase receptor TYRO3 P55144 TYRO3_MOUSE Mus musculus 3 0.7229
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7227
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7227
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 2 0.7224
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 2 0.7224
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7216
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7216
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7197
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7197
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7190
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7190
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.7184
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.7184
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7169
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7169
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7164
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7164
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7164
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7164
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7157
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7157
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7155
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7155
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7141
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7141
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7140
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7140
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7138
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7138
Glutathione S-transferase Q8ILQ7 GST_PLAFA Plasmodium falciparum 3 0.7135
Glutathione S-transferase Q8ILQ7 GST_PLAFA Plasmodium falciparum 3 0.7135
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7135
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7135
Heat shock cognate 71 kDa protein P11142 HSP7C_HUMAN Homo sapiens 2 0.7124
Heat shock cognate 71 kDa protein P11142 HSP7C_HUMAN Homo sapiens 2 0.7124
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7120
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7120
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7119
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7119
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7118
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.7118
GMP reductase Q81JJ9 GUAC_BACAN Bacillus anthracis 2 0.7116
GMP reductase Q81JJ9 GUAC_BACAN Bacillus anthracis 2 0.7116
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7110
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7110
Nucleoside diphosphate kinase Q9U1E1 Q9U1E1_LEIMA Leishmania major 3 0.7105
Nucleoside diphosphate kinase Q9U1E1 Q9U1E1_LEIMA Leishmania major 3 0.7105
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7103
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7103
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 2 0.7101
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 2 0.7101
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7098
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7098
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7097
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7097
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7095
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7095
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7095
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7095
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7092
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7092
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7086
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7086
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7085
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7085
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7081
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7081
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 2 0.7079
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 2 0.7079
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7076
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7076
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7061
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 3 0.7061
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7044
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7044
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7037
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7037
Leukotriene A(4) hydrolase Q6IP81 Q6IP81_XENLA Xenopus laevis 3 0.7034
Leukotriene A(4) hydrolase Q6IP81 Q6IP81_XENLA Xenopus laevis 3 0.7034
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7032
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7032
Nucleoside diphosphate kinase Q5HFV4 NDK_STAAC Staphylococcus aureus 2 0.7028
Nucleoside diphosphate kinase Q5HFV4 NDK_STAAC Staphylococcus aureus 2 0.7028
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7021
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7021
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7012
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7012
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7011
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7011
M17 leucyl aminopeptidase Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3 0.7007
M17 leucyl aminopeptidase Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 3 0.7007
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7003
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7003

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