5,7-dihydroxy-2',3',4',5'-tetramethoxyflavone - Compound Card

5,7-dihydroxy-2',3',4',5'-tetramethoxyflavone

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5,7-dihydroxy-2',3',4',5'-tetramethoxyflavone

Structure
Zoomed Structure
  • Family: Plantae - Compositae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone
Canonical Smiles COc1cc(c2cc(=O)c3c(o2)cc(cc3O)O)c(c(c1OC)OC)OC
InChI InChI=1S/C19H18O8/c1-23-15-7-10(17(24-2)19(26-4)18(15)25-3)13-8-12(22)16-11(21)5-9(20)6-14(16)27-13/h5-8,20-21H,1-4H3
InChIKey ZYVBPTWKKGRSOZ-UHFFFAOYSA-N
Formula C19H18O8
HBA 8
HBD 2
MW 374.35
Rotatable Bonds 5
TPSA 107.59
LogP 2.91
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.21
Exact Mass 374.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Psiadia punctulata Asteraceae Plantae 72969
2 Psiadia punctulata Compositae Plantae 72969

Showing of synonyms

  • Juma BF, Yenese A, et al. (2001). Flavones and phenylpropenoids in the surface exudate of Psiadia punctulata. Phytochemistry,2001,57(4),571-574. [View] [PubMed]
Pubchem: 5742694
Nmrshiftdb2: 70014149

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 374.35 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 374.35 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 374.35 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.79
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.950
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.37

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.270
Plasma Protein Binding
81.91
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.450
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.910
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.080
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.530
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-1.900
Rat (Acute)
2.100
Rat (Chronic Oral)
2.800
Fathead Minnow
5.020
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
479.080
Hydration Free Energy
-9.380
Log(D) at pH=7.4
3.080
Log(P)
3.02
Log S
-5.64
Log(Vapor Pressure)
-7.84
Melting Point
191.17
pKa Acid
8.65
pKa Basic
3.07
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9657
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9657
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9527
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9527
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9493
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9493
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9356
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9356
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9284
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9284
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9279
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9279
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9200
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9200
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9112
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9112
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9071
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9071
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9061
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9061
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9039
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9039
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9011
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9011
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9005
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9005
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8988
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8988
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8978
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8978
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8968
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8968
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8953
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8953
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8943
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8943
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8935
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8935
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8905
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8905
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 6 0.8878
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 6 0.8878
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8870
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8870
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8860
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8860
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8823
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8823
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8781
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8781
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8769
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8769
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8752
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8752
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8750
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8750
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8739
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8739
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8733
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8733
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8643
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8643
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8595
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8595
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8587
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8587
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.8572
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.8572
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8555
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8555
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8553
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8553
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8530
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8530
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8516
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8516
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8505
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8505
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8486
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8486
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8468
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8468
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8465
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8465
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8420
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8420
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8393
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8393
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8363
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8363
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8358
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8358
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8355
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8355
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8348
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8348
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8345
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8345
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8329
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8329
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8314
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8314
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8297
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8297
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8268
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8268
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8260
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8260
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8243
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8243
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8242
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8242
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8233
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8233
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8204
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8204
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8166
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8166
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8153
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8153
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8100
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8100
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8082
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8082
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8045
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8045
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8045
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8045
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8020
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8020
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8009
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8009
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8007
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8007
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7992
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7992
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7988
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7988
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7979
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7979
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7977
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7977
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7972
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7972
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7972
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7972
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7956
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7956
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7934
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7934
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7934
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7934
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7912
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7912
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7894
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7894
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7875
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7875
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7862
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7862
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7861
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7861
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7834
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7834
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7830
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7830
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7820
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7820
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7806
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7806
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7795
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7795
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7792
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7792
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7790
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7790
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7790
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7790
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7774
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7774
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7771
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7771
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7770
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7770
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7762
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7762
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7736
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7736
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7726
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7726
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 5 0.7697
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 5 0.7697
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7696
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7696
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7679
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7679
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7670
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7670
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7669
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7669
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7668
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7668
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7642
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7642
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7620
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7620
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7617
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7617
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7609
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7609
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7608
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7608
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7580
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7580
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7579
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7579
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7561
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7561
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7552
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7552
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7542
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7542
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7542
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7542
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7539
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7539
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7519
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7519
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7515
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7515
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7495
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7495
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7486
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7486
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7483
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7483
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7475
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7475
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7462
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7462
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7461
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7461
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7460
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7460
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7450
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7450
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7448
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7448
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7439
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7439
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7426
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7426
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7425
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7425
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7424
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7424
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7423
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7423
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7400
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7400
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7399
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7399
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7399
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7399
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7393
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7393
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7392
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7392
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7378
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7378
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7377
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7377
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7365
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7365
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7363
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7363
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7362
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7362
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7360
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7360
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7348
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7348
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7340
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7340
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7325
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7325
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7323
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7323
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7322
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7322
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7321
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7321
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7320
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7320
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7315
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7315
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7308
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7308
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7302
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7302
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7296
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7296
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7293
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7293
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7292
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7292
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7290
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7290
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7286
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7286
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7284
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7284
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7281
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7281
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7258
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7258
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7251
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7251
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7246
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7246
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7238
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7238
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7236
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7236
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7226
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7226
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7225
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7225
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7215
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7215
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7212
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7212
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7205
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7205
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7204
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7204
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7202
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7202
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7201
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7201
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7197
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7197
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7192
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7192
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7186
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7186
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7186
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7186
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7170
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7170
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7164
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7164
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7151
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7151
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7150
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7150
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7150
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7150
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7148
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7148
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7142
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7142
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7137
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7137
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7134
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7134
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7126
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7126
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7119
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7119
CDP-alcohol phosphatidyltransferase AF-2299-like N-terminal domain-containing protein O27985 O27985_ARCFU Archaeoglobus fulgidus 4 0.7111
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7111
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7111
CDP-alcohol phosphatidyltransferase AF-2299-like N-terminal domain-containing protein O27985 O27985_ARCFU Archaeoglobus fulgidus 4 0.7111
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7111
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7111
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7107
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7107
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7107
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7107
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7096
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7096
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7094
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7094
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7088
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7088
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7078
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7078
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7075
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7075
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7074
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7074
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7063
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7063
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7062
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7062
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7061
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7061
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7059
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7059
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7058
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7058
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7049
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7049
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7044
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7044
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7044
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7044
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7041
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7041
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7033
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7033
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7029
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7029
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7024
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7024
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7017
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7017
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7012
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7012
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7009
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7009
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7009
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7009

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