5-hydroxy-7,2',3',4',5'-pentamethoxyflavone - Compound Card

5-hydroxy-7,2',3',4',5'-pentamethoxyflavone

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5-hydroxy-7,2',3',4',5'-pentamethoxyflavone

Structure
Zoomed Structure
  • Family: Plantae - Compositae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone
Canonical Smiles COc1cc(O)c2c(c1)oc(cc2=O)c1cc(OC)c(c(c1OC)OC)OC
InChI InChI=1S/C20H20O8/c1-23-10-6-12(21)17-13(22)9-14(28-15(17)7-10)11-8-16(24-2)19(26-4)20(27-5)18(11)25-3/h6-9,21H,1-5H3
InChIKey UQKOTVMFJYMJEP-UHFFFAOYSA-N
Formula C20H20O8
HBA 8
HBD 1
MW 388.37
Rotatable Bonds 6
TPSA 96.59
LogP 3.21
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 28
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 388.12
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Psiadia punctulata Asteraceae Plantae 72969
2 Psiadia punctulata Compositae Plantae 72969

Showing of synonyms

  • Juma BF, Yenese A, et al. (2001). Flavones and phenylpropenoids in the surface exudate of Psiadia punctulata. Phytochemistry,2001,57(4),571-574. [View] [PubMed]
Pubchem: 5742693
Chebi: 185171
Nmrshiftdb2: 70014153

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 388.37 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 388.37 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 388.37 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.61
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.800
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.48

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.510
Plasma Protein Binding
70.87
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.070
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.010
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.000
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
7.490
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-6.690
Rat (Acute)
2.580
Rat (Chronic Oral)
2.490
Fathead Minnow
5.450
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Toxic

General Properties

Boiling Point
464.080
Hydration Free Energy
-8.060
Log(D) at pH=7.4
3.590
Log(P)
3.2
Log S
-4.5
Log(Vapor Pressure)
-8.01
Melting Point
159.92
pKa Acid
8.5
pKa Basic
2.06
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9543
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9543
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9407
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9407
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9368
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9368
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9300
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9300
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9271
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9271
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9217
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9217
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9210
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9210
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9202
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9202
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9174
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9174
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9146
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9146
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9127
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9127
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9053
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9053
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9016
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9016
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9000
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9000
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8967
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8967
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8920
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8920
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8910
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8910
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8898
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8898
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8885
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8885
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8883
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8883
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8875
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8875
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8857
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8857
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8799
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8799
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8755
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8755
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8721
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8721
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.8703
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.8703
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8652
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8652
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8647
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8647
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8596
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8596
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8591
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8591
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8590
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8590
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8583
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8583
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8551
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8551
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8542
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8542
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8523
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8523
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8513
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8513
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8495
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8495
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8486
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8486
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8440
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8440
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8429
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8429
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8389
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8389
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8375
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8375
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8340
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8340
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8294
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8294
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8285
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8285
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8271
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8271
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8264
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8264
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8249
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8249
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8243
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8243
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8180
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8180
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.8139
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.8139
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8125
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8125
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8095
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8095
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8083
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8083
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8079
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8079
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8056
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8056
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8055
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8055
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8051
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8051
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8048
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8048
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.8000
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8000
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8000
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.8000
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7994
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7994
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7978
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7978
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7972
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7972
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7956
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7956
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7953
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7953
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7949
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7949
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7947
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7947
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7943
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7943
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7943
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7943
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7939
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7939
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7919
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7919
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7907
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7907
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7891
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7891
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7870
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7870
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7856
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7856
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7838
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7838
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7837
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7837
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7837
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7837
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7827
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7827
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7826
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7826
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7822
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7822
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7796
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7796
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7754
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7754
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7752
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7752
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7746
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7746
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7737
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7737
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7733
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7733
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7714
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7714
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7699
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7699
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7695
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7695
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7691
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7691
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7677
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7677
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7675
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7675
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7653
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7653
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7650
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7650
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7649
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7649
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7624
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7624
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7623
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7623
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7621
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7621
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7606
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7606
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7592
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7592
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7586
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7586
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7578
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7578
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7569
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7569
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7556
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7556
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7545
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7545
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7539
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7539
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7499
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7499
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7495
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7495
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7492
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7492
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7489
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7489
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7488
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7488
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7482
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7482
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.7482
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7482
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7478
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7478
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7477
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7477
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7467
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7467
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7464
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7464
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7455
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7455
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7455
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7455
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7453
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7453
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7453
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7453
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7438
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7438
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7434
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7434
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7425
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7425
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7423
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7423
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7408
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7408
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7399
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7399
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7396
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7396
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7395
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7395
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7393
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7393
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7386
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7386
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7378
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7378
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7377
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7377
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7374
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7374
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7370
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7370
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7369
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7369
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7366
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7366
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7364
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7364
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7360
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7360
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7359
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7359
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7354
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7354
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7354
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7354
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7348
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7348
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7339
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7339
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7338
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7338
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7333
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7333
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7322
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7322
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.7321
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.7321
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7318
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7318
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7313
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7313
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7311
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7311
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7310
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7310
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7307
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7307
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7305
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7305
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7295
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7295
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7291
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7291
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7278
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7278
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7277
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7277
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7276
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7276
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7274
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7274
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7273
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7273
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7270
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7270
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7266
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7266
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7261
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7261
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7260
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7260
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7254
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7254
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7235
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7235
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7232
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7232
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7231
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7231
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7227
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7227
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7225
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7225
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7220
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7220
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7216
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7216
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7214
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7214
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7212
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7212
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7205
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7205
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7204
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7204
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7199
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7199
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7180
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7180
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7179
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7179
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7172
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7172
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7170
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7170
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7170
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7170
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7165
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7165
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7163
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7163
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7161
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7161
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7159
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7159
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7151
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7151
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7149
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7149
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7149
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7149
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7148
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7148
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7146
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7146
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7134
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7134
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7131
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7131
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7128
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7128
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7123
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7123
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7120
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7120
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7120
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7120
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7118
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7118
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7106
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7106
Ras-related protein M-Ras O08989 RASM_MOUSE Mus musculus 4 0.7102
Ras-related protein M-Ras O08989 RASM_MOUSE Mus musculus 4 0.7102
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7092
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7092
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 5 0.7089
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 5 0.7089
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7088
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7088
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7080
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7080
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7074
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7074
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7074
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7074
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7074
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7074
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7072
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7072
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7070
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7070
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7067
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7067
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7066
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7066
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7062
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7062
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7056
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7056
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7056
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7056
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7049
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7049
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7037
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7037
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7035
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7035
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7035
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7035
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7032
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7032
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7031
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7031
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7030
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7030
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7027
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7027
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7018
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7018
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7012
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7012
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7000
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7000

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