5,7,3'-trihydroxy-2',4',5'-trimethoxyflavone - Compound Card

5,7,3'-trihydroxy-2',4',5'-trimethoxyflavone

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5,7,3'-trihydroxy-2',4',5'-trimethoxyflavone

Structure
Zoomed Structure
  • Family: Plantae - Compositae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone
Canonical Smiles COc1c(cc(c(c1O)OC)OC)c1cc(=O)c2c(o1)cc(cc2O)O
InChI InChI=1S/C18H16O8/c1-23-14-6-9(17(24-2)16(22)18(14)25-3)12-7-11(21)15-10(20)4-8(19)5-13(15)26-12/h4-7,19-20,22H,1-3H3
InChIKey IFWCMOJROJGCTG-UHFFFAOYSA-N
Formula C18H16O8
HBA 8
HBD 3
MW 360.32
Rotatable Bonds 4
TPSA 118.59
LogP 2.6
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 360.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Psiadia punctulata Asteraceae Plantae 72969
2 Psiadia punctulata Compositae Plantae 72969

Showing of synonyms

  • Juma BF, Yenese A, et al. (2001). Flavones and phenylpropenoids in the surface exudate of Psiadia punctulata. Phytochemistry,2001,57(4),571-574. [View] [PubMed]
Pubchem: 7330522
Nmrshiftdb2: 70067482

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 360.32 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 360.32 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 360.32 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.46
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.120
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.05

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.230
Plasma Protein Binding
85.84
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.630
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.490
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.200
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.730
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.770
Rat (Acute)
2.180
Rat (Chronic Oral)
3.050
Fathead Minnow
4.700
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
492.770
Hydration Free Energy
-10.440
Log(D) at pH=7.4
2.950
Log(P)
2.48
Log S
-6.5
Log(Vapor Pressure)
-7.71
Melting Point
220.24
pKa Acid
7.83
pKa Basic
3.89
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9661
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9661
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9481
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9481
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9461
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9461
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9322
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9322
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9312
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9312
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9282
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9282
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9277
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9277
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.9260
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.9260
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9192
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9192
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9081
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9081
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9029
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9029
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8979
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8979
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8975
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8975
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8973
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8973
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8970
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8970
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8937
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8937
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8901
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8901
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8900
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8900
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8894
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8894
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8883
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8883
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8875
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8875
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8821
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8821
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8814
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8814
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8805
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8805
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8800
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8800
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8788
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8788
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8743
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8743
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8733
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8733
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8725
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8725
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8689
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8689
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8680
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8680
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 6 0.8623
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 6 0.8623
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8565
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8565
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8555
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8555
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8552
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8552
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.8551
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.8551
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.8526
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.8526
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8525
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8525
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8498
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8498
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8497
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8497
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8485
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8485
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8484
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.8484
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8474
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8474
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8446
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8446
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8407
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8407
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8387
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8387
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8375
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8375
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8363
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8363
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8360
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.8360
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8355
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8355
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8351
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8351
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8343
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8343
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8339
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8339
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8330
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8330
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8321
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8321
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8319
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.8319
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8318
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8318
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8279
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8279
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8272
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8272
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8269
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8269
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8263
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8263
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8244
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8244
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8240
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8240
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8222
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8222
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.8210
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.8210
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8201
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8201
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8174
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8174
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8147
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8147
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8141
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8141
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8133
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8133
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.8129
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 4 0.8129
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8114
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8114
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.8079
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.8079
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8065
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8065
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8065
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8065
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8064
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 4 0.8064
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8063
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8063
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8062
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8062
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8032
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8032
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8012
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.8012
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 7 0.7995
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 7 0.7995
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7990
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7990
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7985
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7985
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7985
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7985
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7974
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7974
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7940
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7940
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7929
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7929
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7913
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7913
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7898
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7898
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7895
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7895
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7880
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7880
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7862
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7862
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7859
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7859
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7849
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7849
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7848
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7848
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.7843
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 6 0.7843
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7833
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7833
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7824
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7824
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7813
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 6 0.7813
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7813
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7813
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7790
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7790
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7778
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7778
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7773
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7773
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7764
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7764
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7752
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7752
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 4 0.7747
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 4 0.7747
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7742
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7742
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7737
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7737
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7733
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7733
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7728
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.7728
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7717
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7717
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7715
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 4 0.7715
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7710
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7710
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7701
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7701
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7696
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7696
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7690
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7690
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7690
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7690
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7670
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7670
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7650
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7650
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7645
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7645
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7641
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7641
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7635
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7635
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7631
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7631
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7628
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7628
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7604
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7604
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7603
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7603
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7595
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7595
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7595
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7595
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7590
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7590
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7588
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7588
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7586
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7586
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7565
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7565
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 5 0.7560
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 5 0.7560
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7556
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7556
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7552
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7552
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7545
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7545
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7544
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7544
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7542
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7542
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7529
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7529
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7516
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7516
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7507
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7507
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7491
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7491
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7474
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7474
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7449
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 4 0.7449
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7445
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7445
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7444
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7444
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7435
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7435
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7434
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7434
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7421
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7421
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7416
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7416
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7412
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7412
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7410
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7410
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7396
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7396
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7393
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7393
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7391
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7391
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7372
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7372
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7369
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7369
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7369
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7369
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7368
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7368
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7356
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7356
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7342
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7342
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7342
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7342
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7341
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7341
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7330
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7330
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7327
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7327
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7324
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 4 0.7324
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7323
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7323
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7307
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7307
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7303
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7303
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7297
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7297
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.7295
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 3 0.7295
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7290
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7290
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7283
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7283
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7282
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7282
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7281
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7281
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7272
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7272
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7269
NADPH--cytochrome P450 reductase P00388 NCPR_RAT Rattus norvegicus 4 0.7269
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7267
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7267
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7257
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7257
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7248
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7248
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7244
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7244
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7243
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.7243
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7242
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7242
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7240
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7240
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7232
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7232
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7232
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7232
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7221
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7221
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7219
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7219
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7219
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7219
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7212
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7212
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7206
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7206
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7205
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7205
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7186
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7186
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7186
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7186
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7184
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7184
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7178
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7178
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7161
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7161
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7160
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7160
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7157
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.7157
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7155
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7155
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7151
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7151
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7148
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7148
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7148
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7148
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7146
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7146
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7139
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7139
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7137
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7137
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7135
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7135
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7133
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7133
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7126
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7126
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7125
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7125
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7113
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7113
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7105
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7105
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7100
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7100
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7096
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7096
CDP-alcohol phosphatidyltransferase AF-2299-like N-terminal domain-containing protein O27985 O27985_ARCFU Archaeoglobus fulgidus 4 0.7095
CDP-alcohol phosphatidyltransferase AF-2299-like N-terminal domain-containing protein O27985 O27985_ARCFU Archaeoglobus fulgidus 4 0.7095
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7094
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7094
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7093
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7093
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7091
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7091
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7086
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7086
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 4 0.7073
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 4 0.7073
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7068
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7068
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7065
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7065
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7061
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7061
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7057
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7057
Histone-arginine methyltransferase CARM1 Q4AE70 CARM1_RAT Rattus norvegicus 4 0.7043
Histone-arginine methyltransferase CARM1 Q4AE70 CARM1_RAT Rattus norvegicus 4 0.7043
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7042
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7042
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7041
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7041
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7031
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7031
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7023
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7023
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7021
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7021
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7013
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 4 0.7013
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7007
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7007
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7006
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7006
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7005
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7005
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7002
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7002

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